苏州医学院临床医学学士，www.优德88.cpm 免疫学硕士、内科血液学博士，美国匹兹堡大学医学院免疫学博士后。现任www.优德88.cpm 医学生物技术研究所所长、www.优德88.cpm 苏州医学院免疫学系教授/博导、系主任。主要从事免疫调节和肿瘤免疫治疗研究，主持和参与国家级研究科研项目多项，在Journal of Immunology、Cancer Letters、Molecular cancer等期刊发表SCI论文多篇，获得国家发明专利授权5件，作为主要成员获省部级科技进步奖二等奖2项；参编中国科学技术协会《2014-2015免疫学学科发展报告》、《免疫学前沿进展》（人民卫生出版社）、《医学免疫学》（高等教育出版社）等；主持江苏省留学生免疫学精品课程项目；获评江苏省高校“青蓝工程”培养对象优秀青年骨干教师；现任江苏省免疫学会常务理事。
免疫调节与肿瘤免疫治疗：
免疫系统与肿瘤细胞相互作用决定着肿瘤的病程和转归。课题组的研究旨在利用免疫调控基因“武装”溶瘤病毒系统干预机体肿瘤免疫态势，实现安全、有效、全身和持久的抗肿瘤免疫效应并阐明其内在作用机制，从而探索并建立具有临床转化价值的肿瘤免疫治疗新策略、新方法和新技术。
1. Chen L, Chen H, Ye J, Ge Y, Wang H, Dai E, Ren J, Liu W, Ma C,Ju SG, Guo ZS, Liu Z, Bartlett, DL. Intratumoral expression of interleukin 23 variants using oncolytic vaccinia virus elicit potent antitumor effects on multiple tumor models via tumor microenvironment modulation. Theranostics. 2021;11(14):6668-6681.
2.Ju SW#,*, Wang F#, Wang Y,Ju SG*. CSN8 is a key regulator in hypoxia-induced epithelial-mesenchymal transition and dormancy of colorectal cancer cells. Molecular Cancer. 2020; 19(1):168.（*Corresponding author）
3.Ge Y#, Chen W#, Zhang, XG, Wang H, Cui J, Liu Y, Ju SW*, Tian X*,Ju SG*. Nuclear-localized costimulatory molecule 4-1BBL promotes colon cancer cell proliferation and migration by regulating nuclear Gsk3beta, and is linked to the poor outcomes associated with colon cancer. Cell cycle.2020;19(5): 577-591.（*Corresponding author）
4.Ge Y#，Wang H#，Ren J，Liu W，Chen L，Chen H，Ye J，Dai E，Ma C，Ju SG，Guo ZS*，Liu Z, Bartlett DL*. Journal for Immunotherapy of Cancer. 2020;8(1): e000710.
5. Zhuang YH, Liu H, Tang J, Wang YZ, Zheng XH, Gong Y, Xu XF, Gao X, Lu RQ,Ju SG*, Guo L*. Screening for syphilis with dual algorithms: analysis of discordant and concordant serology results in a population with a low prevalence of syphilis. Journal of the European Academy of Dermatology and Venereology : JEADV. 2019; 33(1):178-184.（*Corresponding author）
6.Liu Z, Ge Y, Wang H, Ma C, Feist M,Ju SG, Guo Z, Bartlett DL*. Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2. Nature Communication. 2018; 9(1):4682.
7.Ju SW#,*, Ge Y#, Li P, Tian X, Wang H, Zheng X,Ju SG*. Dietary quercetin ameliorates experimental colitis in mouse by remodeling the function of colonic macrophages via a heme oxygenase-1-dependent pathway. Cell Cycle. 2018;17(1):53-63.（*Corresponding author）
8.Chen W#, Ju SW#, Lu T,Xu Y, Zheng X, Wang H, Ge Y*,Ju SG*. Directional delivery of RSPO1 by mesenchymal stem cells ameliorates radiation-induced intestinal injury. Cytokine. 2017; 95:27-34.（*Corresponding author）
9.Ye X#, Ju SW#, Duan H, Yao Y, Wu J, Zhong S, Chen L, Cao S, Xu Y, Zheng X, Wang H, Ge Y*,Ju SG*. Immune checkpoint molecule PD-1 acts as a novel biomarker for the pathological process of gestational diabetes mellitus. Biomark Med. 2017; 11(9):741-749.（*Corresponding author）
10. Zhang Y, Wang Z, Zhang L, Zhou D, Sun Y, Wang P,Ju SG, Chen P, Li J, Fu J*. Impact of connexin 43 coupling on survival and migration of multiple myeloma cells. Arch Med Sci. 2017 Oct;13(6):1335-1346.
11. Ge Y#, Deng Y#, Chen W#, Xu Y, Ju SW*,Ju SG*.Rspo1/LGR5 pathway promotes cervical cancer cell growth and is correlated with the high pathological grade. Int J Clin Exp Pathol. 2016;9(9):9048-9057.（*Corresponding author）
12.Ge Y#, Xi H#,Ju SG*, Zhang XG*. Blockade of PD-1/PD-L1 immune checkpoint during DC vaccination induces potent protective immunity against breast cancer in hu-SCID mice. Cancer letters. 2013;336(2):253-259. (*Corresponding author)
13.Zhang K#, Chen W#, Zhang Y, GeY, Ju SW, Yang P, Tan YF, Ge ZJ, Gao ZH, Zhao YP, Wu HR*,Ju SG*. An Anti-Human CD13 Monoclonal Antibody That Suppresses the Suppressive Function of Treg Cells. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 2013, 32(1): 16-20.(*Corresponding author)
14.Kovacs JR, Li C, Yang Q, Li G, Garcia IG,Ju SG, Roodman DG, Windle JJ, Zhang XG, Lu B*. Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery. Cell Death Differ. 2012;19(1):144-152.
15.Ju SG#, Xue Z#, Ju S, Ge Y, Xie W, Zhu H, Pan J, Zhang XG*. An anti-human FLT3 monoclonal antibody that inhibits the proliferation of monocytic leukemia cell line SHI-1. Hybridoma. 2011;30(1):61-67.
16. Ge Y#, Chen YG#,Ju SG, Zhang XG*.Functional expression of chimeric Fab of an anti-CD40L mAb: vector design and culture condition optimization.Biomedicine & Pharmacotherapy. 2011;65(1):52-59.
17.Zhu Y#,Ju SG#（#并列第1作者）, Chen E, Dai S, Li C, Morel P, Liu L, Zhang X, Lu B*. T-bet and Eomesodermin Are Required for T Cell-Mediated Antitumor Immune Responses. J Immunol. 2010;185(6):3174-3183.
18.Ju SG, Zhu Y, Liu L, Dai S, Li C, Chen E, He Y, Zhang XG, Lu BF*. Gadd45b and Gadd45g are important for anti-tumor immune responses. Euro J Immunol. 2009; 39(11): 3010–3018.
19.Ju SW#, Qiu H#, Zhou X, Zhu B, Lv X, Huang X, Li J, Zhang Y, Liu L, Ge Y, Johnson DE,Ju SG*, Shu YQ*. CD13+CD4+CD25hiRegulatory T Cells Exhibit Higher Suppressive Function and Increase with Tumor Stage in Non-Small Cell Lung Cancer patients. Cell Cycle. 2009; 8(16): 2578-2585.（*Corresponding author）
20.Ju SW#,Ju SG#,*, Ge Y, Qiu HX, Lu BF, Qiu YH, Fu JX, Liu GQ, Wang Q, Hu YM, Shu YQ, Zhang XG*. A novel approach to induce human DCs from monocytes by triggering 4-1BBL reverses signaling. Int.Immunol. 2009;21(10):1135-1144.（*Corresponding author）
21.Gonzalez-García I, Zhao YN,Ju SG, Gu Q, Liu L, Kolls JK, Lu B*. IL-17 Signaling Independent Central Nervous System Autoimmunity Is Negatively Regulated by TGF-β. J. Immunol. 2009;182(5): 2665 -2671.
22.Zhang GB, Dong QM, Hou JQ, Ge Y,Ju SG, Lu BF, Zhang XG*. Characterization and application of three novel monoclonal antibodies against human 4-1BB: distinct epitopes of human 4-1BB on lung tumor cells and immune cells. Tissue Antigens. 2007;70(6): 470-479.
23.Wang F, Zhu W, Liu T, Sun Z,Ju SG, Ju SW, Yu G, Xie W, Deng Z, Lu B, Zhang XG*. The expression analysis of ICOS-L on activated T cells and immature dendritic cells as well as malignant B cells and Grave's-disease-derived thyroid tissues by two novel mAbs against human ICOS-L.Tissue Antigens. 2007;69(1):62-72.
24.Deng ZB, Zhu W, Lu CM, Shi Q,Ju SG, Ma HB, Xu Y, Zhang XG*.An agonist human ICOS monoclonal antibody that induces T cell activation and inhibits proliferation of a myeloma cell line. Hybrid Hybridomics. 2004;23(3):176-182.
25. Ju SW#,Ju SG#（#并列第1作者）, Wang FM, Gu ZJ, Qiu YH, Yu GH, Ma HB, Zhang XG*. A Functional Anti-Human 4-1BB Ligand Monoclonal Antibody That Enhances Proliferation of Monocytes by Reverses Signaling of 4-1BBL.Hybridoma and Hybridomics. 2003;22:333-338.
苏州医学院临床医学学士，www.优德88.cpm 免疫学硕士、内科血液学博士，美国匹兹堡大学医学院免疫学博士后。现任www.优德88.cpm 医学生物技术研究所所长、www.优德88.cpm 苏州医学院免疫学系教授/博导、系主任。主要从事免疫调节和肿瘤免疫治疗研究，主持和参与国家级研究科研项目多项，在Journal of Immunology、Cancer Letters、Molecular cancer等期刊发表SCI论文多篇，获得国家发明专利授权5件，作为主要成员获省部级科技进步奖二等奖2项；参编中国科学技术协会《2014-2015免疫学学科发展报告》、《免疫学前沿进展》（人民卫生出版社）、《医学免疫学》（高等教育出版社）等；主持江苏省留学生免疫学精品课程项目；获评江苏省高校“青蓝工程”培养对象优秀青年骨干教师；现任江苏省免疫学会常务理事。
免疫调节与肿瘤免疫治疗：
免疫系统与肿瘤细胞相互作用决定着肿瘤的病程和转归。课题组的研究旨在利用免疫调控基因“武装”溶瘤病毒系统干预机体肿瘤免疫态势，实现安全、有效、全身和持久的抗肿瘤免疫效应并阐明其内在作用机制，从而探索并建立具有临床转化价值的肿瘤免疫治疗新策略、新方法和新技术。
1. Chen L, Chen H, Ye J, Ge Y, Wang H, Dai E, Ren J, Liu W, Ma C,Ju SG, Guo ZS, Liu Z, Bartlett, DL. Intratumoral expression of interleukin 23 variants using oncolytic vaccinia virus elicit potent antitumor effects on multiple tumor models via tumor microenvironment modulation. Theranostics. 2021;11(14):6668-6681.
2.Ju SW#,*, Wang F#, Wang Y,Ju SG*. CSN8 is a key regulator in hypoxia-induced epithelial-mesenchymal transition and dormancy of colorectal cancer cells. Molecular Cancer. 2020; 19(1):168.（*Corresponding author）
3.Ge Y#, Chen W#, Zhang, XG, Wang H, Cui J, Liu Y, Ju SW*, Tian X*,Ju SG*. Nuclear-localized costimulatory molecule 4-1BBL promotes colon cancer cell proliferation and migration by regulating nuclear Gsk3beta, and is linked to the poor outcomes associated with colon cancer. Cell cycle.2020;19(5): 577-591.（*Corresponding author）
4.Ge Y#，Wang H#，Ren J，Liu W，Chen L，Chen H，Ye J，Dai E，Ma C，Ju SG，Guo ZS*，Liu Z, Bartlett DL*. Journal for Immunotherapy of Cancer. 2020;8(1): e000710.
5. Zhuang YH, Liu H, Tang J, Wang YZ, Zheng XH, Gong Y, Xu XF, Gao X, Lu RQ,Ju SG*, Guo L*. Screening for syphilis with dual algorithms: analysis of discordant and concordant serology results in a population with a low prevalence of syphilis. Journal of the European Academy of Dermatology and Venereology : JEADV. 2019; 33(1):178-184.（*Corresponding author）
6.Liu Z, Ge Y, Wang H, Ma C, Feist M,Ju SG, Guo Z, Bartlett DL*. Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2. Nature Communication. 2018; 9(1):4682.
7.Ju SW#,*, Ge Y#, Li P, Tian X, Wang H, Zheng X,Ju SG*. Dietary quercetin ameliorates experimental colitis in mouse by remodeling the function of colonic macrophages via a heme oxygenase-1-dependent pathway. Cell Cycle. 2018;17(1):53-63.（*Corresponding author）
8.Chen W#, Ju SW#, Lu T,Xu Y, Zheng X, Wang H, Ge Y*,Ju SG*. Directional delivery of RSPO1 by mesenchymal stem cells ameliorates radiation-induced intestinal injury. Cytokine. 2017; 95:27-34.（*Corresponding author）
9.Ye X#, Ju SW#, Duan H, Yao Y, Wu J, Zhong S, Chen L, Cao S, Xu Y, Zheng X, Wang H, Ge Y*,Ju SG*. Immune checkpoint molecule PD-1 acts as a novel biomarker for the pathological process of gestational diabetes mellitus. Biomark Med. 2017; 11(9):741-749.（*Corresponding author）
10. Zhang Y, Wang Z, Zhang L, Zhou D, Sun Y, Wang P,Ju SG, Chen P, Li J, Fu J*. Impact of connexin 43 coupling on survival and migration of multiple myeloma cells. Arch Med Sci. 2017 Oct;13(6):1335-1346.
11. Ge Y#, Deng Y#, Chen W#, Xu Y, Ju SW*,Ju SG*.Rspo1/LGR5 pathway promotes cervical cancer cell growth and is correlated with the high pathological grade. Int J Clin Exp Pathol. 2016;9(9):9048-9057.（*Corresponding author）
12.Ge Y#, Xi H#,Ju SG*, Zhang XG*. Blockade of PD-1/PD-L1 immune checkpoint during DC vaccination induces potent protective immunity against breast cancer in hu-SCID mice. Cancer letters. 2013;336(2):253-259. (*Corresponding author)
13.Zhang K#, Chen W#, Zhang Y, GeY, Ju SW, Yang P, Tan YF, Ge ZJ, Gao ZH, Zhao YP, Wu HR*,Ju SG*. An Anti-Human CD13 Monoclonal Antibody That Suppresses the Suppressive Function of Treg Cells. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 2013, 32(1): 16-20.(*Corresponding author)
14.Kovacs JR, Li C, Yang Q, Li G, Garcia IG,Ju SG, Roodman DG, Windle JJ, Zhang XG, Lu B*. Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery. Cell Death Differ. 2012;19(1):144-152.
15.Ju SG#, Xue Z#, Ju S, Ge Y, Xie W, Zhu H, Pan J, Zhang XG*. An anti-human FLT3 monoclonal antibody that inhibits the proliferation of monocytic leukemia cell line SHI-1. Hybridoma. 2011;30(1):61-67.
16. Ge Y#, Chen YG#,Ju SG, Zhang XG*.Functional expression of chimeric Fab of an anti-CD40L mAb: vector design and culture condition optimization.Biomedicine & Pharmacotherapy. 2011;65(1):52-59.
17.Zhu Y#,Ju SG#（#并列第1作者）, Chen E, Dai S, Li C, Morel P, Liu L, Zhang X, Lu B*. T-bet and Eomesodermin Are Required for T Cell-Mediated Antitumor Immune Responses. J Immunol. 2010;185(6):3174-3183.
18.Ju SG, Zhu Y, Liu L, Dai S, Li C, Chen E, He Y, Zhang XG, Lu BF*. Gadd45b and Gadd45g are important for anti-tumor immune responses. Euro J Immunol. 2009; 39(11): 3010–3018.
19.Ju SW#, Qiu H#, Zhou X, Zhu B, Lv X, Huang X, Li J, Zhang Y, Liu L, Ge Y, Johnson DE,Ju SG*, Shu YQ*. CD13+CD4+CD25hiRegulatory T Cells Exhibit Higher Suppressive Function and Increase with Tumor Stage in Non-Small Cell Lung Cancer patients. Cell Cycle. 2009; 8(16): 2578-2585.（*Corresponding author）
20.Ju SW#,Ju SG#,*, Ge Y, Qiu HX, Lu BF, Qiu YH, Fu JX, Liu GQ, Wang Q, Hu YM, Shu YQ, Zhang XG*. A novel approach to induce human DCs from monocytes by triggering 4-1BBL reverses signaling. Int.Immunol. 2009;21(10):1135-1144.（*Corresponding author）
21.Gonzalez-García I, Zhao YN,Ju SG, Gu Q, Liu L, Kolls JK, Lu B*. IL-17 Signaling Independent Central Nervous System Autoimmunity Is Negatively Regulated by TGF-β. J. Immunol. 2009;182(5): 2665 -2671.
22.Zhang GB, Dong QM, Hou JQ, Ge Y,Ju SG, Lu BF, Zhang XG*. Characterization and application of three novel monoclonal antibodies against human 4-1BB: distinct epitopes of human 4-1BB on lung tumor cells and immune cells. Tissue Antigens. 2007;70(6): 470-479.
23.Wang F, Zhu W, Liu T, Sun Z,Ju SG, Ju SW, Yu G, Xie W, Deng Z, Lu B, Zhang XG*. The expression analysis of ICOS-L on activated T cells and immature dendritic cells as well as malignant B cells and Grave's-disease-derived thyroid tissues by two novel mAbs against human ICOS-L.Tissue Antigens. 2007;69(1):62-72.
24.Deng ZB, Zhu W, Lu CM, Shi Q,Ju SG, Ma HB, Xu Y, Zhang XG*.An agonist human ICOS monoclonal antibody that induces T cell activation and inhibits proliferation of a myeloma cell line. Hybrid Hybridomics. 2004;23(3):176-182.
25. Ju SW#,Ju SG#（#并列第1作者）, Wang FM, Gu ZJ, Qiu YH, Yu GH, Ma HB, Zhang XG*. A Functional Anti-Human 4-1BB Ligand Monoclonal Antibody That Enhances Proliferation of Monocytes by Reverses Signaling of 4-1BBL.Hybridoma and Hybridomics. 2003;22:333-338.