王崇龙，理学博士，毕业于韩国庆尚大学（Gyeongsang National University）应用生命科学部生物工程专业，现为www.优德88.cpm 基础医学与生物科学学院教师。研究兴趣在于微生物代谢工程和合成生物学。

1. 韩国庆尚大学应用生命科学部兼职教授

2. 苏州市生物学监事会监事

萜类化合物（Terpenoids）是自然界中种数庞大、结构多样的一类天然化合物。已知的化合物包括单萜、倍半萜、二萜、类胡萝卜素等50,000多种，并表现出具有的不同生物活性和功能。因而被广泛用做抗肿瘤、消炎止痛的药物，及环保杀虫剂、除草剂等。日前，正在使用的萜类化合物的市场需求非常稳定，价格非常有竞争力。然而，此类化合物从自然界提取的产量极其有限，且严重受制于气候和生长地域等自然条件的影响；化学合成又因化合物本身结构复杂，化学合成步骤繁琐、得率不高而非常难以量产。此外，萜烯（烃）具有媲美汽油的物理和化学特性，近年来被聚焦为可直接替代传统化石燃料的新一代生物燃料而备受关注。因此，发展绿色生物合成提高功能性萜类化合物的产量非常具有市场价值和可持续性发展的意义。研究组主要聚焦于代谢工程和合成生物学研究，旨在建立以合成生物技术为依托的萜类化合物合成平台，推进萜类化合物的规模化生产和应用。

1. 微生物的代谢工程设计与改造

2. 高附加值的药物前体和生物燃料（萜类化合物）的生物合成
3. 菌株抗性和适应性研究
4. 合成生物学元件和工具开发

1. Microbial engineering and metabolic design
2. Biosynthesis of value-addedIsoprenoid products as medicines and biofuels
3. Improvement of cell fitness and tolerance in engineering strains
4. Development of Synthetic biology parts and tools

1.生物学方向，学术学位硕士研究生

2.生物工程方向，专业学位硕士研究生

发表论文

WangChonglong*,ZhaoShuli , Shao Xixi, Park Ji‑Bin, Jeong Seong‑Hee, Park Hyo‑Jin, Kwak Won‑Ju, Wei Gongyuan, Kim Seon‑Won, Challenges and tackles in metabolic engineering for microbial production of carotenoids，Microbial Cell Factories，2019.03.18，18:55

WangChonglong*, Liwei Mudanguli, Park Ji-Bin, Jeong Seong-Hee, Wei Gongyuan, Wang Yujun, Kim Seon‑Won, Microbial Platform for terpenoid production:Escherichia coliand Yeast，Frontiers In Microbiology，2018.10.12，9

Xu Ruoyang, Wang Dahui,Wang Chonglong, Zhang Gaochuan, Wei Gongyuan^*. Improved S-adenosyl methionine and glutathione biosynthesis by heterologous expression of anATP6gene inCandida utilis.J Basic Microbiol.2018.07.31. doi: 10.1002/jobm.201800151

Wang Chonglong^#, Zada Bakht^#,Park Ji-Bin,Jeong Seong-Hee,Park Ju-Eon,Singh Hawaibam Birlia,Kim Seon-Won. Metabolic engineering ofEscherichiacolifor production of mixed isoprenoid alcohols and their derivatives. Biotechnol Biofuels. 2018.07.24, 11:210

Liu Bo, Zhou Yang, Li Kun, Hu Xiaolong,Wang Chonglong, Cao Guangli, Xue Renyu, Gong Chongliang. The complete genome of Cyprinid herpesvirus 2, a new strain isolated fromAllogynogeneticcruciancarp. Virus Res. 2018 07.24. S0168-1702(18)30262-4.

Han Jong-Yun, Song Jae-Myeong, Seo Sung-Hwa,Wang Chonglong, Lee Seung-Goo, Lee Hongweon, Kim Seon-Won, Choi Eui-Sung, Ty1-fused protein-body formation for spatial organization of metabolic pathways inSaccharomyces cerevisiae, Biotechnol Bioeng. 20180301, 115(3):694-704

Wang Chonglong^#, Zada Bakht^#, Wei Gongyuan, Kim Seon-Won^*, Metabolic engineering and synthetic biology approaches driving isoprenoid production inEscherichia coli, Bioresour Technol. 2017.10.01, 241: 430-438.

Wang Chonglong^#, pfleger Brian F.^*, Kim Seon-Won^*,ReassessingEscherichia colias a cell factory for biofuel production, Curr Opin Biotechnol. 2017.06.01, 45: 92-103

Zhou Jia, Yang Liyang,Wang Chonglong, Choi Eui-Sung, Kim Seon-Won. Enhanced performance of the methylerythritol phosphate pathway by manipulation of redox reactions relevant to IspC, IspG, and IspH. J Biotechnol. 2017.04.20, 248:1-8.

Kim Jung-Hun^#,Wang Chonglong, Jang Hui-Jung, Cha Myeong-Seok, Park Ju-Eon, Jo Seon-Yeong, Choi Eui-Sung^*, Kim Seon-Won^*, Isoprene production byEscherichia colithrough the exogenous mevalonate pathway with reduced formation of fermentation byproducts, Microb Cell Fact, 2016.12.23, 15(1): 214~214

Wang Chonglong^#, Park Ju-Eon, Choi Eui-Sung^*, Kim Seon-Won^*, Farnesol production inEscherichia colithrough the construction of a farnesol biosynthesis pathway - application of PgpB and YbjG phosphatases, Biotechnol J, 2016.10.01,11(10): 1291~1297

Wang Chonglong^#, Yang Liyang^#, Zhou Jia, Kim Seon-Won^*, Combinatorial engineering of hybrid mevalonate pathways inEscherichia colifor protoilludene production, Microb Cell Fact, 2016.01.19, 15: 14~14

Wang Chonglong^#, Yang Liyang, Shah Asad Ali, Choi Eui-Sung^*, Kim Seon-Won^*, Dynamic interplay of multidrug transporters with TolC for isoprenol tolerance inEscherichia coli, Sci Rep, 2015.11.13, 5: 16505~16505

Wang Chonglong^#*, Kim Seon-Won^*, Shaking up ancient scents: Insights into santalol synthesis in engineeredEscherichia coli, Process Biochem, 2015.08.01, 50(8): 1177~1183

Zhou Jia^#,Wang Chonglong^#, Yang Liyang, Choi Eui-Sung^*, Kim Seon-Won^*, Geranyl diphosphate synthase: an important regulation point in balancing a recombinant monoterpene pathway inEscherichia coli, Enzyme Microb Technol, 2015.01.01, 68: 50~55

Wang Chonglong^#, Kim Jung-Hun^#, Kim Seon-Won^*, Synthetic biology and metabolic engineering for marine carotenoids: new opportunities and future prospects, Mar Drugs, 2014.09.17, 12(9): 4810~4832

Zhou Jia^#,Wang Chonglong, Yoon Sang-Hwal, Jang Hui-Jeong, Choi Eui-Sung^*, Kim Seon-Won^*, EngineeringEscherichia colifor selective geraniol production with minimized endogenous dehydrogenation, J Biotechnol, 2014.01.01, 169: 42~50

Shah Asad Ali^#,Wang Chonglong^#, Yoon Sang-Hwal, Kim Jae-Yean, Choi Eui-Sung, Kim Seon-Won^*, RecA-mediated SOS response provides a geraniol tolerance inEscherichia coli, J Biotechnol, 2013.09.20, 167(4): 357~364

Wang Chonglong^#, Zhou Jia, Jang Hui-Jeong, Yoon Sang-Hwal, Kim Jae-Yean, Lee Seung-Goo, Choi Eui-Sung^*, Kim Seon-Won^*, Engineered heterologous FPP synthases-mediatedZ,E-FPP synthesis in E. coli, Metab Eng, 2013.07.01, 18: 53~59

Shah Asad Ali^#,Wang Chonglong^#, Chung Young-Ryun, Kim Jae-Yean, Choi Eui-Sung, Kim Seon-Won^*, Enhancement of geraniol resistance ofEscherichia coliby MarA overexpression, J Biosci Bioeng, 2013.03.01, 115(3): 253~258

Wang Chonglong^#, Yoon Sang-Hwal, Jang Hui-Jeong, Chung Young-Ryun, Kim Jae-Yean, Choi Eui-Sung^*, Kim Seon-Won^*, Metabolic engineering ofEscherichia colifor alpha-farnesene production, Metab Eng, 2011.11.01, 13(6): 648~655

Wang Chonglong^#, Kim Jae-Yean, Choi Eui-Sung^*, Kim Seon-Won^*, Microbial production of farnesol (FOH): Current states and beyond, Process Biochemistry, 2011.06.01, 46(6): 1221~1229

Wang Chonglong^#, Yoon Sang-Hwal, Shah Asad Ali, Chung Young-Ryun, Kim Jae-Yean, Choi Eui-Sung, Keasling Jay D, Kim Seon-Won^*, Farnesol production fromEscherichia coliby harnessing the exogenous mevalonate pathway, Biotechnol Bioeng, 2010.10.15, 107(3): 421~429

Jang Hui-Jeong^#, Yoon Sang-Hwal, Ryu Hee-Kyung, Kim Jung-Hun,Wang Chonglong, Kim Jae-Yean, Oh Deok-Kun, Kim, Seon-Won^*, Retinoid production using metabolically engineeredEscherichia coliwith a two-phase culture system, Microb Cell Fact, 2011.07.29, 10: 59~59

发明专利

1．一种生产α-檀香烯的方法，申请号：10-2015-0189254，公开号：10-2016-0018443，公开日期：2016年2月 17日，韩国，本人排名2/总人数2

2．一种提高微生物醇类抗性的方法及抗性微生物的制备，申请号：10-2015-0115374，韩国，本人排名2/总人数2

3．融合Z,E-法尼基二磷酸合成酶和E. coli 法尼基二磷酸合成酶的方法及其应用，申请号：10-2011-0115390，登录号：10-1285315，公开号：10-2013-0050178公开日期：2013年5月 15日，韩国，本人排名2/总人数5

4．提高大肠杆菌属微生物α-法尼烯合成能力的方法及其应用，申请号：10-2011-0010772，登录号：10-1285312，公开号：10-2012-0099817，公开日：2012年9月 12日，韩国，本人排名2/总人数5

5．提高大肠杆菌属微生物α-法尼醇合成能力的方法及其应用，申请号：10-2010-0115735，公开号：10-2012-0088062公开日期：2012年8月 8日，韩国，本人排名2/总人数5