生物信息学、系统生物学、医学信息学

目前主要从事基于生物医学多模态数据的多尺度生物网络模型的构建、分析与应用，尝试从分子、细胞、表型等刻画并预测癌症（特别是胃癌）的发生发展，为理解癌症的演变机制、生物标志物的识别、癌症的诊疗等提供理论指导。

承担科研项目

1、国家自然科学基金青年基金，基于氨基酸接触能网络的蛋白质结合位点分析，19 万，2017-2019，主持

2、江苏省重点研发计划，基于人工智能算法的胃癌早期诊断及发展预警模型的构建及应用，200万，2020-2023，项目骨干

本科生

1、生物信息学算法，2019年至今

2、生物信息学导论，2021年至今

3、Biopython，2019年

研究生

1、医学生物信息学，2022年至今

2、R语言基础，2019年

3、Python/Biopython编程，2019年

2023年

MiR-200/183 family-mediated module biomarker for gastric cancer progression: an AI-assisted bioinformatics method with experimental functional survey.

Wenying Yan; Yuqi Chen; Guang Hu; Tongguo Shi; Xingyi Liu; Juntao Li; Linqing Sun; Fuliang Qian; Weichang Chen.

Journal of Translational Medicine, 2023, 21(1) (SCI大类二区，第一作者)

Integrated multi-dimensional analysis highlights DHCR7 mutations involving in cholesterol biosynthesis and contributing therapy of gastric cancer.

Yuqi Chen;Wenying Yan; Kexi Yang; Yiting Qian; Yanjun Chen; Ruoqin Wang; Jinghan Zhu; Yuxin He; Hongya Wu; Guangbo Zhang; Tongguo Shi; Weichang Chen.

Journal of Experimental & Clinical Cancer Research, 2023, 42(1)(SCI大类一区，并列第一作者)

Identifying lymph node metastasis-related factors in breast cancer using differential modular and mutational structural analysis.

Xingyi Liu; Bin Yang; Xinpeng Huang;Wenying Yan; Yujuan Zhang; Guang Hu.

Interdisciplinary Sciences: Computational Life Sciences, 2023, Online ahead of print(SCI大类三区，并列通讯作者)

A comprehensive review on knowledge graphs for complex diseases.

Yang, Yang; Lu, Yuwei;Yan, Wenying.

Briefings in Bioinformatics, 2023, 24(1)(SCI大类二区，通讯作者)

A protein co-conservation network model characterizes mutation effects on SARS-CoV-2 spike protein.

Lianjie Zeng; Yitan Lu;Wenying Yan; Yang Yang

International Journal of Molecular Sciences, 2023, 24(4): 3255(SCI大类二区，并列通讯作者)

DeepTP: A deep learning model for thermophilic protein prediction.

Jianjun Zhao;Wenying Yan; Yang Yang

International Journal of Molecular Sciences, 2023, 24(3): 2217(SCI大类二区，并列通讯作者)

2022年

Structural Biology Meets Biomolecular Networks: The Post-AlphaFold Era

Wenying Yan; Guang Hu

Current Bioinformatics, 2022, 17(6).(SCI大四区，第一作者)

2021年

Knowledge-Guided “Community Network” Analysis Reveals the Functional Modules and Candidate Targets in Non-Small-Cell Lung Cancer

Fan Wang; Shuqing Han; Ji Yang;Wenying Yan; Guang Hu

Cells, 2021, 10(2): 402.(SCI大类二区，并列通讯作者)

Network-Based Target Prioritization and Drug Candidate Identification for Multiple Sclerosis: From Analyzing “Omics Data” to Druggability Simulations

Ji Yang; Hongchun Li; Fan Wang; Fei Xiao;Wenying Yan; Guang Hu

ACS Chemical Neuroscience, 2021, 12(5): 917-929.(SCI大类二区，并列通讯作者)

Deciphering the in vivo Dynamic Proteomics of Mesenchymal Stem Cells in Critical Limb Ischemia

Yipeng Du; Xiaoting Li;Wenying Yan; Zhaohua Zeng; Dunzheng Han; Hong Ouyang; Xiudi Pan; Bihui Luo; Bohua Zhou; Qiang Fu; Dongfeng Lu; Zheng Huang; Zhiliang Li

Frontiers in Cell and Developmental Biology, 2021, 9(SCI大类二区，并列第一作者)

2020年

Evaluation of plasma exosomal microRNAs as circulating biomarkers for progression and metastasis of gastric cancer

Yuqi Chen; Huang Feng; Yanlin Wu; Ruoqin Wang; Zhaoji Li; Jiajia Chen;Wenying Yan; Weichang Chen

Clinical and Translational Medicine, 2020, 10(6). (SCI大类一区，并列通讯作者)

Identifying drug targets in pancreatic ductal adenocarcinoma through machine learning, analyzing biomolecular networks, and structural modeling

Wenying Yan; Xingyi Liu; Yibo Wang; Shuqing Han; Fan Wang; Xin Liu; Fei Xiao; Guang Hu

Frontiers in Pharmacology, 2020, 11: 0-534.(SCI大类二区，第一作者)

ANCA: A web server for amino acid networks construction and analysis

Wenying Yan; Chunjiang Yu; Jiajia Chen; Jianhong Zhou; Bairong Shen

Frontiers in Molecular Biosciences, 2020, 7: 582702.(SCI大类二区，第一作者)

Understanding the cross-talk between host and virus in poultry from the perspectives of microRNA

Xiujun Duan; Lihua Wang; Guobo Sun;Wenying Yan; Yang Yang

Poultry Science, 2020, 99(4): 1838-1846.(SCI大类二区，并列通讯作者)

2018年

Node-Weighted amino acid network strategy for characterization and identification of protein functional residues

Wenying Yan; Guang Hu; Zhongjie Liang; Jianhong Zhou; Yang Yang; Jiajia Chen; Bairong Shen

Journal of Chemical Information and Modeling, 2018, 58(9): 2024-2032.(SCI大类二区，第一作者，JCIM封面论文)

Recent Advances on the Network Models in Target-based Drug Discovery

Wenying Yan; Daqing Zhang; Chen Shen; Zhongjie Liang; Guang Hu

Current Topics in Medicinal Chemistry,2018, 18(13): 1031-1043.(SCI大类四区，第一作者)

2016年

Network analysis of protein structures: the comparison of three topologies

Wenying Yan; Guang Hu; Bairong Shen

Current Bioinformatics, 2016, 11(4): 480-489.(SCI大类三区，第一作者)

Comparison of prognostic microrna biomarkers in blood and tissues for gastric cancer

Wenying Yan; Laijun Qian; Jiajia Chen; Weichang Chen; Bairong Shen

Journal of Cancer, 2016, 7(1): 95-106.(SCI大类三区，第一作者)

2014年

Amino acid contact energy networks impact protein structure and evolution

Wenying Yan; Maomin Sun; Guang Hu; Jianhong Zhou; Wenyu Zhang; Jiajia Chen; Biao Chen; Bairong Shen

Journal of Theoretical Biology, 2014, 355: 95-104.(SCI大类三区，第一作者)

The construction of an amino acid network for understanding protein structure and function

Wenying Yan; Jianhong Zhou; Maomin Sun; Jiajia Chen; Guang Hu; Bairong Shen

Amino Acids, 2014, 46(6): 1419-1439.(SCI大类三区，第一作者)

SVR_CAF: an integrated score function for detecting native protein structures among decoys

Jianhong Zhou;Wenying Yan; Guang Hu; Bairong Shen

Proteins, 2014, 82(4): 556-564.(SCI大类三区，并列第一作者)

Amino acid network for the discrimination of native protein structures from decoys

Jianhong Zhou;Wenying Yan; Guang Hu; Bairong Shen

Current Protein and Peptide Science, 2014, 15(6): 522-528.(SCI大类三区，并列第一作者)

专著

沈百荣主编，严文颖、张文宇、钱福良、 林宇鑫副主编，《深度测序数据的生物信息学分析及实例》，2017，科学出版社，ISBN：9787030545800

专利

2、杨洋;朱冠臣;丁雪松;吕强;严文颖;朱斐。一种基于序列预测蛋白质变性温度的系统及其方法。授权日期：2023-3-31。专利号：ZL201910719819.6

1、严文颖;沈百荣;杨洋。基于结构网络模型的蛋白质功能位点预测方法。授权日期：2021-3-30。专利号：ZL201810643576.8