医学博士，www.优德88.cpm 医学部基础医学与生物科学学院病理学与病理生理学系副教授，从事科研及教学工作。多年来一直致力于研究心血管疾病的发病机制，特别是钙激活钾通道及钠通道在糖尿病心血管病变及缺血性心脏疾病发生发展中的作用及其调控机制。 至2022年共获得校级、省级及国家级基金资助6项，在SCI收录期刊上发表研究性论文20余篇。
钙激活钾通道及钠通道在心血管疾病发生发展中的作用及其调控机制。
[1] ZHAO L,You T, Lu Y, Lin S,et al.Elevated EZH2 in ischemic heart disease epigenetically mediates suppression of NaV1.5 expression.J Mol Cell Cardiol2021; 153:95-103.
[2] Zhao LM, Sun L, Lu Y,et al.A small-molecule LF3 abrogates β-catenin/TCF4-mediated suppression of NaV1.5 expression in HL-1 cardiomyocytes.J Mol Cell Cardiol2019;135(13):90-6.
[3] Zhao LM, Wang LP, Wang HF,et al.The role of KCa3.1 channels in cardiac fibrosis induced by pressure overload in rats.Pflugers Arch2015;467(11):2275-85.
[4] Zhao LM, Wang Y, Yang Y,et al.Metformin Restores Intermediate-Conductance Calcium- Activated K+channel- and Small-Conductance Calcium-Activated K+channel-Mediated Vasodilatation Impaired by Advanced Glycation End Products in Rat Mesenteric Artery.Mol Pharmacol2014;86(5):580-91
[5] Zhao LM, Wang Y, Ma XZ,et al.Advanced glycation end products impair KCa3.1- and KCa2.3-mediated vasodilatation via oxidative stress in rat mesenteric arteries.Pflugers Arch2014;466(2):307-17.
[6] Zhao LM, Su XL, Wang Y,et al.KCa3.1 channels mediate the increase of cell migration and proliferation by advanced glycation end products in cultured rat vascular smooth muscle cells.Lab Invest2013; 93(2):159-67.
[7] Zhao LM,Zhang W, Wang LP,et al.Advanced glycation end products promote proliferation of cardiac fibroblasts by upregulation of KCa3.1 channels.Pflugers Arch2012; 464(6): 613-21.
[8] 赵丽梅，王燕，杨勇等.钙激活钾通道在高糖所致内皮源性超极化因子介导的内皮舒张功能障碍中的作用.西安交通大学学报（医学版）2013; 34(5);609-13.
[9][9]Zhao LM, Wang Y, Ma XZ,et al. Oxidative stress impairs IKCa- and SKCa-mediated vasodilatation in mesenteric arteries from diabetic rats.J South Med Univ2013; 33(7): 939-44.
[10[10] Cai BZ*,Zhao LM*, Wang N,et al. Bone marrow mesenchymal stem cells upregulate transient outward potassium currents in postnatal rat ventricular myocytes.J Mol Cell Cardiol2009; 47(1): 41-8.
[11] Ai J*,Zhao LM*, Lu YJ,et al. A randomized, multicentre, open-Label, parallel-group trial to compare the efficacy and safety profile of Daming capsule in patients with hypercholesterolemia.Phytother Res2009; 23(7): 1039-42.
[12] Zhao LM, Yuan BX, Wei XZ,et al. Effect of Seabuckthorn fatty acids on apoptosis in ovarian granulosa cells of aged rats.Chin Pharmacol Bull2006; 22(3): 317-20.
[13] Huo R, Hu C,Zhao L,et al.Enhancement of beta-catenin/T-cell factor 4 signaling causes susceptibility to cardiac arrhythmia by suppressing NaV1.5 expression in mice.Heart rhythm2019;16(11):1720-8.
[14]Ma XZ, Pang ZD, Wang JH, Song Z,Zhao LM,et al.The role and mechanism of KCa3.1 channels in human monocyte migration induced by palmitic acid.Exp Cell Res2018; 369(2):208-17.
医学博士，www.优德88.cpm 医学部基础医学与生物科学学院病理学与病理生理学系副教授，从事科研及教学工作。多年来一直致力于研究心血管疾病的发病机制，特别是钙激活钾通道及钠通道在糖尿病心血管病变及缺血性心脏疾病发生发展中的作用及其调控机制。 至2022年共获得校级、省级及国家级基金资助6项，在SCI收录期刊上发表研究性论文20余篇。
钙激活钾通道及钠通道在心血管疾病发生发展中的作用及其调控机制。
[1] ZHAO L,You T, Lu Y, Lin S,et al.Elevated EZH2 in ischemic heart disease epigenetically mediates suppression of NaV1.5 expression.J Mol Cell Cardiol2021; 153:95-103.
[2] Zhao LM, Sun L, Lu Y,et al.A small-molecule LF3 abrogates β-catenin/TCF4-mediated suppression of NaV1.5 expression in HL-1 cardiomyocytes.J Mol Cell Cardiol2019;135(13):90-6.
[3] Zhao LM, Wang LP, Wang HF,et al.The role of KCa3.1 channels in cardiac fibrosis induced by pressure overload in rats.Pflugers Arch2015;467(11):2275-85.
[4] Zhao LM, Wang Y, Yang Y,et al.Metformin Restores Intermediate-Conductance Calcium- Activated K+channel- and Small-Conductance Calcium-Activated K+channel-Mediated Vasodilatation Impaired by Advanced Glycation End Products in Rat Mesenteric Artery.Mol Pharmacol2014;86(5):580-91
[5] Zhao LM, Wang Y, Ma XZ,et al.Advanced glycation end products impair KCa3.1- and KCa2.3-mediated vasodilatation via oxidative stress in rat mesenteric arteries.Pflugers Arch2014;466(2):307-17.
[6] Zhao LM, Su XL, Wang Y,et al.KCa3.1 channels mediate the increase of cell migration and proliferation by advanced glycation end products in cultured rat vascular smooth muscle cells.Lab Invest2013; 93(2):159-67.
[7] Zhao LM,Zhang W, Wang LP,et al.Advanced glycation end products promote proliferation of cardiac fibroblasts by upregulation of KCa3.1 channels.Pflugers Arch2012; 464(6): 613-21.
[8] 赵丽梅，王燕，杨勇等.钙激活钾通道在高糖所致内皮源性超极化因子介导的内皮舒张功能障碍中的作用.西安交通大学学报（医学版）2013; 34(5);609-13.
[9][9]Zhao LM, Wang Y, Ma XZ,et al. Oxidative stress impairs IKCa- and SKCa-mediated vasodilatation in mesenteric arteries from diabetic rats.J South Med Univ2013; 33(7): 939-44.
[10[10] Cai BZ*,Zhao LM*, Wang N,et al. Bone marrow mesenchymal stem cells upregulate transient outward potassium currents in postnatal rat ventricular myocytes.J Mol Cell Cardiol2009; 47(1): 41-8.
[11] Ai J*,Zhao LM*, Lu YJ,et al. A randomized, multicentre, open-Label, parallel-group trial to compare the efficacy and safety profile of Daming capsule in patients with hypercholesterolemia.Phytother Res2009; 23(7): 1039-42.
[12] Zhao LM, Yuan BX, Wei XZ,et al. Effect of Seabuckthorn fatty acids on apoptosis in ovarian granulosa cells of aged rats.Chin Pharmacol Bull2006; 22(3): 317-20.
[13] Huo R, Hu C,Zhao L,et al.Enhancement of beta-catenin/T-cell factor 4 signaling causes susceptibility to cardiac arrhythmia by suppressing NaV1.5 expression in mice.Heart rhythm2019;16(11):1720-8.
[14]Ma XZ, Pang ZD, Wang JH, Song Z,Zhao LM,et al.The role and mechanism of KCa3.1 channels in human monocyte migration induced by palmitic acid.Exp Cell Res2018; 369(2):208-17.