张晗

副教授，研究生导师

2019年获山东大学化学系博士学位，2019年至2022年在www.优德88.cpm 功能纳米与软物质研究院从事博士后研究工作。2022年被www.优德88.cpm 聘为副教授，同年入选“www.优德88.cpm 优秀青年学者”。

研究领域：肽基生物材料；大分子药物递送体系；粘膜相关疾病的局部给药系统；疾病的免疫疗法

主要成果和贡献：

致力于生物、材料、物理、化学和医学的交叉领域，针对生命科学与临床医学中的重要科学问题，发展了一系列新型高效的生物材料，研究了其在抗病毒、抗炎与抗肿瘤等方面的应用；设计构建了多种新型的大分子药物（抗体、细胞因子、酶、核酸等）递送体系，深入研究了其跨屏障递送机制，并探索了其在眼睛、口腔、膀胱等粘膜相关疾病中的应用。在PNAS，Adv.Mater.，ACS Nano等期刊发表论文十余篇。参与国家重点研发计划“纳米前沿”重点专项等项目；主持中国博士后基金面上项目、国家自然科学基金青年科学基金项目和国家自然科学基金面上项目等。

代表性论文：

[1]. Ming Shao, Yu Chai, Yutong Jiang, Xinyi Wu, Wenjie Xie, Jiayi Lu, Xuehui Fu, Yao He, Xiaofeng Zhang*,Han Zhang*, Zhuang Liu*. Eye-Drop Nano-Formulation of Catalase Self-Assembled with Thiolated Chitosan for Effective Treatment of Dry Eye Disease.Adv.Mater.2025,2415353, 1-16.

[2].Han Zhang,Wenjun Zhu, Qiutong Jin, Feng Pan, Jiafei Zhu, Yanbin Liu, Linfu Chen, Jingjing Shen, Yang Yang*, Qian Chen*, Zhuang Liu*, Inhalablenanocatchersfor SARS-CoV-2 inhibition.Proc. Natl. Acad. Sci. U.S.A.2021, 118, e2102957118.

[3]. Yutong Jiang, Xuehui Fu, Ming Shao, Wanwan Chang,Han Zhang*, Zhuang Liu*, Eyedrop delivery of therapeutic proteins with zwitterionic polymers to treat dry age-related macular degeneration.Biomaterials2024, 305, 122429.

[4].Han Zhang*, Yanbin Liu, Zhuang Liu*, Nanomedicine approaches against SARS-CoV-2 and variants.J. Control. Release2024, 365, 101-111.

[5].Han Zhang,Kai Liu, Yimou Gong, Wenjun Zhu, Jiafei Zhu, Feng Pan, Yu Chao,ZhishenXiao, Yanbin Liu, Xianwen Wang, Zhuang Liu, Yang Yang*, Qian Chen*,Vitamin C supramolecular hydrogel for enhanced cancer immunotherapy.Biomaterials2022, 287, 121673.

[6].Han Zhang, Kai Liu, Shukun Li, Xia Xin*, Shiling Yuan*, Guanghui Ma,XuehaiYan*, Self-Assembled Minimalist Multifunctional Theranostic Nanoplatform for Magnetic Resonance Imaging-Guided Tumor Photodynamic Therapy.ACS Nano2018, 12, 8266-8276.

[7].Han Zhang, Jiafei Zhu, Tianxu Fang, Meng Li, Guojun Chen*, Qian Chen*, Supramolecular biomaterials for enhanced cancer immunotherapy.J. Mater. Chem. B2022,10, 7183-7193.

[8].Han Zhang, Lei Kang, Qianli Zou, Xia Xin, Xuehai Yan*, Coordination-assembled supramolecular nanoplatforms:structuralmodulationand theranostic applications.Curr. Opin. Biotech.2019, 58, 45-52.

[9]. Yuankai Zhang,Han Zhang(Co-first author), Qianli Zou, Ruirui Xing, Tingfeng Jiao, Xuehai Yan*, An injectable dipeptide–fullerene supramolecular hydrogel for photodynamic antibacterial therapy.J. Mater. Chem. B2018, 6, 7335-7342.

[10].Han Zhang, Lingyu Guo, Jianmei Jiao, Xia Xin*, Di Sun, Shiling Yuan*, Ionic Self-Assembly of Polyoxometalate Dopamine Hybrid Nanoflowers with Excellent Catalytic Activity for Dyes.ACS Sustain. Chem. Eng.2017, 5, 1358-1367.

[11].Han Zhang, Xia Xin*, Jichao Sun, Liupeng Zhao, Jinglin Shen, Zhaohua Song, Shiling Yuan*, Self-assembled chiral helical nanofibers by amphiphilic dipeptide derived from D- or L-threonine and application as a template for the synthesis of Au and Ag nanoparticles.J ColloidInterf. Sci.2016, 484, 97-106.

[12].Han Zhang, Lingyu Guo, Zengchun Xie, Xia Xin*, Di Sun, Shiling Yuan*, Tunable Aggregation-Induced Emission of Polyoxometalates via Amino Acid-Directed Self-Assembly and Their Application in Detecting Dopamine.Langmuir2016, 32, 13736-13745.

[13].Han Zhang, Menghong Yu, Aixin Song, Yawen Song, Xia Xin*, Jinglin Shen, Shiling Yuan*, Modulating hierarchical self-assembly behavior of a peptide amphiphile/nonionic surfactant mixed system.RSC Adv.2016, 6, 9186-9193.

[14].Han Zhang, Jichao Sun, Xia Xin*, Wenlong Xu, Jinglin Shen, Zhaohua Song, Shiling Yuan*, Modulating self-assembly behavior of a salt-free peptide amphiphile (PA) and zwitterionic surfactant mixed system.J ColloidInterf. Sci.2016, 467, 43-50.

联系方式：hanzhang@suda.edu.cn