李雨晴

副教授，研究生导师

硕士毕业于中南大学化学化工学院，2021年博士毕业于加拿大滑铁卢大学化学系(University of Waterloo)，2022年起在www.优德88.cpm FUNSOM从事博士后研究，随后入职FUNSOM任副教授。

主要成果和贡献：

近年来主要聚焦靶向蛋白降解领域，致力于针对传统药物难以靶向或疗效不佳的致病蛋白进行活性调控。基于化学生物学、分子工程等多学科方法，利用功能核酸、融合蛋白等分子工具，通过理性设计和定向进化等手段，实现高选择性、高安全性的致病蛋白降解。此外，还致力于开发基于功能核酸的诊疗新策略。目前以第一作者和共同通讯作者在J. Am. Chem. Soc., Chem, Angew. Chem. Int. Ed., ACS Central Science, Chemical Science等国际权威学术期刊发表论文18篇。在学术期刊Frontiers in Chemistry担任Review Editor（in section of Analytical Chemistry）和Guest Associate Editor（in section of Medical and Pharmaceutical Chemistry）。

个人荣誉：

海外高层次青年人才B类

江苏省卓越博士后计划

R.H.F. Manske Prize(加拿大滑铁卢大学, 1/27, 唯一获奖人）

Provost Doctoral Entrance Award (PDEA) for Women

代表性论文：

[1] X. Wang, L. Tian,Y. Li*, W. Yao, J. Zhu, H. Zhou, G. Chen, T. Chen, Z. Liu, W. Tan*, Y. Yang* A universal albumin drugs-cored spherical nucleic acid (ad-SNA) platform for targeted drug delivery,Angew. Chem. Int. Ed., 2025, in press.

[2] J. Chen,Y. Li*, X. Liu, H. Li, J. Zhu, R. Ma, L. Tian, L. Yu. J. Li, Z. Liu, W. Tan, Y. Yang* “Antigen spatial matching polyaptamer nanostructure for blocking coronavirus infection and alleviating inflammation”,Chem, 2024, DOI:10.1016/j.chempr.2024.10.021.

[3]Y. Li,X. Liu, L. Yu, X. Huang, X. Wang, D. Han*, Y. Yang*, Z. Liu* “Covalent LYTAC enabled by DNA aptamers for immune checkpoint degradation therapy”,J. Am. Chem. Soc., 2023, 145, 45, 24506–24521.

[4]Y. Li,H. Gao, Z. Qi, Z. Huang, L. Ma, J. Liu* “Freezing‐assisted conjugation of unmodified diblock DNA to hydrogel nanoparticles and monoliths for DNA and Hg²⁺sensing”,Angew. Chem. Int. Ed., 2021, 60 (23), 12985-12991.

[5]Y. Li,B. Liu, Z. Huang and J. Liu* “Engineering base-excised aptamers for highly specific recognition of adenosine”,Chemical Science, 2020, 11 (10), 2735-2743.

[6] R. Yuan,Y. Li,S. Han, X. Chen, J. Chen, J. He, H. Gao*, Y. Yang* “Fe-curcumin nanozyme-mediated reactive oxygen species scavenging and anti-inflammation for acute lung injury”,ACS Central Science, 2022, 8 (1), 10–21.

[7]Y. Li,J. Liu* “Nanozyme’s catching up: activity, specificity, reaction conditions and reaction types”,Materials Horizons, 2020, 8, 336-350.

[8] Z. Cheng, J. Wei, L. Gu, L. Zou, T. Wang, L. Chen,Y. Li*,Y. Yang, P. Li* “DNAzyme-based biosensors for mercury (II) detection: rational construction, advances and perspectives”,Journal of Hazardous Materials, 2022, 431, 128606.

[9]Y. Li, J. Chen, J. Wei, X. Liu, L. Yu, L. Yu*, D. Ding*, Y. Yang* “Metallic nanoplatforms for COVID‑19 diagnostics: versatile applications in the pandemic and post‑pandemic era”,Journal of Nanobiotechnology, 2023, 21 (1), 255.

[10]Y. Li,J. Liu* “Highly specific recognition of guanosine using engineered base excised aptamers”,Chemistry–A European Journal, 2020, 26 (60), 13644-13651.

[11]Y. Li,M. Zandieh, and J. Liu* “Modulation of DNAzyme activity via butanol dehydration”,Chemistry–An Asian Journal, 2021, 16 (24): 4062-4066.

联系方式：yqli719@suda.edu.cn