方向介绍：

以抗体、多肽、核酸等为代表的大分子药物在各类疾病治疗中发挥着越来越重要的作用。与小分子药物多样化的给药方式不同，大分子药物由于自身分子量大难以有效透过各种生理屏障，在临床使用时大多依靠注射给药，一定程度上降低了患者依从性。本实验室的一个重要研究方向是发展大分子药物的非注射给药新型递送载体，这些纳米载体可以携带抗体等大分子药物穿透各类生物屏障，实现大分子药物的口服、滴眼、透皮以及滴鼻给药等。这些创新的给药技术有望为自身免疫疾病、代谢类疾病以及其他慢病提供更为便捷、安全、有效的治疗方案。

代表性论文：

(1) Ming Shao; Yu Chai; Yutong Jiang; Xinyi Wu; Wenjie Xie; Jiayi Lu; Xuehui Fu; Yao He; Xiaofeng Zhang*; Han Zhang*; Zhuang Liu*. “Eye-Drop Nano-Formulation of Catalase Self-Assembled with Thiolated Chitosan for Effective Treatment of Dry Eye Disease”Advanced Materials, e2415353(2025)

(2)Wenjun Zhu, Ting Wei, Yuchun Xu, Qiutong Jin, Yu Chao, Jiaqi Lu, Jun Xu, Jiafei Zhu, Xiaoying Yan, Muchao Chen, Qian Chen *, Zhuang Liu*.“Non-invasive transdermal delivery of biomacromolecules with fluorocarbon-modified chitosan for melanoma immunotherapy and viral vaccines”Nature Communications, 15, 820 (2024)

(3)Jingjing Shen, Huiqin Gao, Linfu Chen, Yutong Jiang, Shu Li, Yu Chao, Nanhui Liu, Yufei Wang, Ting Wei, Yan Liu, Jipeng Li, Muchao Chen, Jiafei Zhu, Juan Liang, Xiaoyu Zhou, Xiaofeng Zhang*, Ping Gu*, Qian Chen*, Zhuang Liu*.“Eyedrop-based macromolecular ophthalmic drug delivery for ocular fundus disease treatment”Science Advances, 9, 4 (2023)

(4) Wenjun Zhu, Yu Chao, Qiutong Jin, Linfu Chen, Jingjing Shen, Jiafei Zhu, Yu Chai, Panhao Lu, Nailin Yang, Muchao Chen, Yang Yang*, Qian Chen*, and Zhuang Liu*. “Oral Delivery of Therapeutic Antibodies with a Transmucosal Polymeric Carrier”ACS Nano, 17, 5, 4373-4386 (2023)

(5) Guangzhi Li, Shupeng Wang, Dashi Deng, Zhisheng Xiao, Ziliang Dong, Zhiping Wang, Qifang Lei, Shan Gao, Guixiao Huang, Enpu Zhang, Guohua Zeng, Zhong Wen, Song Wu*, and Zhuang Liu*.“Fluorinated Chitosan To Enhance Transmucosal Delivery of Sonosensitizer-Conjugated Catalase for Sonodynamic Bladder Cancer Treatment Post-intravesical Instillation”ACS Nano, 14, 2,1586-1599 (2020)