Yu Chao

Associate Professor, master's supervisor

Obtained a Bachelor's degree in Biofunctional Materials from Soochow University in 2015; a Ph.D. in Chemistry from Soochow University in 2020; engaged in postdoctoral research at Soochow University from 2020 to 2023. In 2023, joined the Institute of Functional Nano & Soft Materials at Soochow University and was appointed as an Associate Professor.

Main Achievements and Technical Contributions:

In recent years, I have been engaged in research in the fields of nano-biomaterials and tumor immunotherapy. I have developed a series of drug delivery systems based on natural polymer materials and systematically explored new strategies for localized tumor treatment and tumor immunotherapy mediated by biomaterials. In addition, I have carried out a series of systematic work in the construction of natural polymer hydrogel carriers, loading and release of small or large molecule drugs, regulation of the tumor microenvironment, and enhancement of immune checkpoint blockade therapy by biomaterials, achieving research results with certain international influence. The clinical translation of related technologies is steadily advancing, and the first clinical human administration has been completed.

I have published a total of 55 SCI papers in international academic journals, including 10 papers as the first author (or co-first author) in internationally renowned academic journals such as Nature Reviews Bioengineering, Nature Biomedical Engineering, Science Advances, Advanced Functional Materials, Nano Letters, ACS Nano Biomaterials, Small, etc. Many articles have been highly cited and widely reported by the National Natural Science Foundation and relevant academic media. The total number of citations for the papers exceeds 6,000, with an H-index of 44. I have applied for 5 invention patents, all of which have been transferred.

Awards:

· Received the May Fourth Youth title from Soochow University in 2020;

· Received the China Postdoctoral Innovation Talents Support Program in 2020.

Recruitment Direction:This research direction warmly welcomes undergraduate and graduate students who are interested in scientific research to join our research group for study and work. The recruitment direction is Materials Science and Engineering (Direction 04, Bio-nano Materials and Biomedical Materials). Students with backgrounds in chemistry, materials, or biomedical fields are encouraged to apply. For any questions, please feel free to contact via email.ychao@suda.edu.cn

Publications
https://webofscience.clarivate.cn/wos/author/record/JRW-9818-2023

Representative papers

[1]Yu Chao, Zhuang Liu*,“Biomaterials tools to modulate the tumour microenvironment in immunotherapy”,Nature Reviews Bioengineering, 1, 125-138 (2023).

[2] Zhu, Wenjun;Chao, Yu; Jin, qiutong; Chen, Linfu; Shen, Jing-Jing; Zhu, Jiafei; Chai, Yu; Lu, Panhao; Yang, Nailin ; Chen, Muchao; Yang, Yang; Chen, Qian; Liu, Zhuang*, “Oral delivery of therapeutic antibodies with a transmucosal polymeric carrier”,ACS Nano, 10.1021/acsnano.2c09266 (2023). (┼ equal contribution authors)

[3]Yu Chao, Ting Wei, Qiaofeng Li, Bo Liu, Yu Hao, Muchao Chen, Yuzhe Wu, Fanxin Song, Qian Chen*, Zhuang Liu*, Metformin-containing Hydrogel Scaffold to Augment CAR-T Therapy Against Post-surgical Solid Tumors,Biomaterials, 10.1016/j.biomaterials.2023.122052 (2023).

[4] Qiaofeng Li,Yu Chao*, Bo Liu, Zhisheng Xiao, Zhijuan Yang, Yuzhe Wu, Zhuang Liu*, “Disulfiram loaded calcium phosphate nanoparticles for enhanced cancer immunotherapy”,Biomaterials, 291,121880 (2022).

[5]Yu Chao, Chao Liang, Huiquan Tao, Yaran Du, Di Wu, Ziliang Dong, Qiutong Jin, Guobin Chen, Jun Xu, Zhisheng Xiao, Qian Chen, Chao Wang, Jian Chen, Zhuang Liu*. “Localized cock-tail chemo-immunotherapy after in situ gelation to trigger robust systemic antitumor immune responses.”Science Advances, 6(10), eaaz4204 (2020)

[6]Yu Chao, Guobin Chen, Chao Liang, Jun Xu, Ziliang Dong, Xiao Han, Chao Wang, Zhuang Liu*. “Iron Nanoparticles for Low-Power Local Magnetic Hyperthermia in Combination with Immune Checkpoint Blockade for Systemic”Nano Lett., 19(7), 4287- 4296 (2019)

[7]Yu Chao, Qian Chen*, Zhuang Liu*. “Smart Injectable Hydrogels for Cancer Immunotherapy”Adv. Funct. Mater.,1902785 (2019)

[8]Yu Chao, Ligeng Xu, Chao Liang, Liangzhu Feng, Jun Xu, Ziliang Dong, Longlong Tian, Xuan Yi, Kai Yang*, Zhuang Liu*. Combined Local Immunostimulatory Radioisotope Therapy and Systemic Immune Checkpoint Blockade Imparts Potent Antitumour ResponsesNature Biomedical Engineering, 2, 611-621(2018)

[9]Yu Chao, Chao Liang, Yu Yang, Guanglin Wang, Debabrata Maiti, Longlong Tian, Fei Wang, Wei Pan, Song Wu*, Kai Yang*, Zhuang Liu*. Highly Effective Radioisotope Cancer Therapy with a Non-Therapeutic Isotope Delivered and Sensitized by Nanoscale Coordination PolymersACS Nano, 12 (8), 7519-7528 (2018)

[10]Yu Chao, Guanglin Wang, Chao Liang, Xuan Yi, Xiaoyan Zhong, Jingjing Liu, Min Gao, Kai Yang*, Liang Cheng*, Zhuang Liu*. “Rhenium-188 Labeled Tungsten Disulfide Nanoflakes for Self-Sensitized, Near-Infrared Enhanced Radioisotope Therapy”Small, 12, 3967-3975 (2016)

Email:ychao@suda.edu.cn