2023(4 Publications)

Z. Liang, T. Liu, Q. Li, G. Zhang, B. Zhang, X. Du, J. Liu, Z. Chen, H. Ding, G. Hu, H. Lin, F. Zhu, C. Luo,Deciphering the functional landscape of phosphosites with deep neural network.Cell Reports42, 113048 (2023)(SCI大类一区)

F. Zhu, L. Deng, Y. Dai, G. Zhang, F. Meng, C. Luo, G. Hu,Z. Liang,PPICT: an integrated deep neural network for predicting inter-protein PTM cross-talk.Briefings inBioinformatics24, (2023)(SCI大类二区)

Z. Zhou, Y. Lu, Z. Gu, Q. Sun, W. Fang, W. Yan, X. Ku,Z. Liang, G. Hu,HNRNPA2B1 as a potential therapeutic target for thymic epithelial tumor recurrence: An integrative network analysis.Computers in Biology and Medicine155, 106665 (2023)(SCI大类二区，并列通讯作者)

H. Jiang, S. Zu, Y. Lu, Z. Sun, A. Adeerjiang, Q. Guo, H. Zhang, C. Dong, Q. Wu, H. Ding, D. Du, M. Wang, C. Liu, Y. Tang,Z. Liang, C. Luo,A RhoA structure with switch II flipped outward revealed the conformational dynamics of switch II region.Journal ofStructural Biology, 107942 (2023)(SCI大类三区，并列通讯作者)

2022(2 Publications)

F. Zhu, S. Yang, F. Meng, Y. Zheng, X. Ku, C. Luo, G. Hu,Z. Liang,Leveraging Protein Dynamics to Identify Functional Phosphorylation Sites using Deep Learning Models.Journal ofChemicalInformation and Modeling62, 3331-3345 (2022)(SCI大类二区)

F. Zhu, F. Li, L. Deng, F. Meng,Z. Liang,Protein Interaction Network Reconstruction with a Structural Gated Attention Deep Model by Incorporating Network Structure Information.Journal of Chemical Information and Modeling62, 258-273 (2022)(SCI大类二区)

2021(4 Publications)

Y. Zhu, F. Ye, Z. Zhou, W. Liu,Z. Liang, G. Hu,Insights into Conformational Dynamics and Allostery in DNMT1-H3Ub/USP7 Interactions.Molecules26, (2021)(SCI大类二区,并列通讯作者)

H. Zhang, J. He, G. Hu, F. Zhu, H. Jiang, J. Gao, H. Zhou, H. Lin, Y. Wang, K. Chen, F. Meng, M. Hao, K. Zhao, C. Luo,Z. Liang,Dynamics of Post-Translational Modification Inspires Drug Design in the Kinase Family.Journal ofMedicinalChemistry64, 15111-15125 (2021)(SCI大类一区)

F. Meng,Z. Liang, K. Zhao, C. Luo,Drug design targeting active posttranslational modification protein isoforms.MedicinalResearch Reviews41, 1701-1750 (2021)(SCI大类一区，并列一作)

Z. Liang, Y. Zhu, J. Long, F. Ye, G. Hu,Both intra and inter-domain interactions define the intrinsic dynamics and allosteric mechanism in DNMT1s.Computational and Structural Biotechnology Journal41, 1701–1750 (2021)(SCI大类二区)

2020(2 Publications)

Z. Liang, Y. Zhu, X. Liu, G. Hu,Role of protein-protein interactions in allosteric drug design for DNA methyltransferases.Adv Protein Chem Struct Biol121, (2020)

Z. Liang, G. M. Verkhivker, G. Hu,Integration of network models and evolutionary analysis into high-throughput modeling of protein dynamics and allosteric regulation: theory, tools and applications.Briefings inBioinformatics21, 815-835 (2020)(SCI大类一区)

2018(2 Publications)

W. Yan, D. Zhang, C. Shen,Z. Liang, G. Hu,Recent Advances on the Network Models in Target-based Drug Discovery.CurrentTopics inMedicinal Chemistry18, 1031-1043 (2018)(SCI大类三区，并列通讯作者)

Z. Liang, J. Hu, W. Yan, H. Jiang, G. Hu, C. Luo,Deciphering the role of dimer interface in intrinsic dynamics and allosteric pathways underlying the functional transformation of DNMT3A.Biochimica etBiophysicaActa. GeneralSubjects1862, 1667-1679 (2018)(SCI大类二区)

2016(1 Publication)

P. Xu, G. Hu, C. Luo,Z. Liang,DNA methyltransferase inhibitors: an updated patent review (2012-2015).ExpertOpinion on Therapeutic Patents26, 1017-1030 (2016)(SCI大类二区)

2015(4 Publications)

R. Zhou, Y. Xie, H. Hu, G. Hu, V. S. Patel, J. Zhang, K. Yu, Y. Huang, H. Jiang,Z. Liang, Y. G. Zheng, C. Luo,Molecular Mechanism underlying PRMT1 Dimerization for SAM Binding and Methylase Activity.Journal of Chemical Information and Modeling55, 2623-2632 (2015)(SCI大类二区，并列通讯作者)

J. Lu, H. Zeng,Z. Liang, L. Chen, L. Zhang, H. Zhang, H. Liu, H. Jiang, B. Shen, M. Huang, M. Geng, S. Spiegel, C. Luo,Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets.ScientificReports5, 14739 (2015)(SCI大类二区，并列一作)

Z. Liang, G. Hu, Protein Structure Network-based Drug Design.Mini-Rev Med Chem16, 1330-1343 (2015)(SCI大类三区)

Z. Jiang,Z. Liang, B. Shen, G. Hu,Computational Analysis of the Binding Specificities of PH Domains.BioMedResearch International2015, 792904 (2015)(SCI大类三区，并列一作)

2014(2 Publications)

K. Zhu, X. Kong, D. Zhao,Z. Liang, C. Luo,c-MET kinase inhibitors: a patent review (2011 - 2013).ExpertOpinion on Therapeutic Patents24, 217-230 (2014)(SCI大类二区，并列通讯作者)

Y. Xie, R. Zhou, F. Lian, Y. Liu, L. Chen, Z. Shi, N. Zhang, M. Zheng, B. Shen, H. Jiang,Z. Liang, C. Luo,Virtual screening and biological evaluation of novel small molecular inhibitors against protein arginine methyltransferase 1 (PRMT1).Organic & Biomolecular Chemistry12, 9665-9673 (2014)(SCI大类二区，并列通讯作者)

2013 and before(6 Publications)

Z. Liang, J. Ai, X. Ding, X. Peng, D. Zhang, R. Zhang, Y. Wang, F. Liu, M. Zheng, H. Jiang, H. Liu, M. Geng, C. Luo, AnthraquinoneDerivatives as Potent Inhibitors of c-Met Kinase and the Extracellular Signaling Pathway.ACS Medicinal Chemistry Letters4, 408-413 (2013)

Z. Liang, L. Zhang, L. Li, J. Liu, H. Li, L. Chen, K. Cheng, M. Zheng, X. Wen, P. Zhang, J. Hao, Y. Gong, X. Zhang, X. Zhu, J. Chen, H. Liu, H. Jiang, C. Luo, H. Sun,Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies.Eur J Med Chem46, (2011)

Z. Liang, D. Zhang, J. Ai, L. Chen, H. Wang, X. Kong, M. Zheng, H. Liu, C. Luo, M. Geng, H. Jiang, K. Chen,Identification and synthesis of N'-(2-oxoindolin-3-ylidene)hydrazide derivatives against c-Met kinase.Bioorg Med Chem Lett21, 3749-3754 (2011)

Z. Liang, L. Li, Y. Wang, L. Chen, X. Kong, Y. Hong, L. Lan, M. Zheng, C. Guang-Yang, H. Liu, X. Shen, C. Luo, K. K. Li, K. Chen, H. Jiang,Molecular basis of NDM-1, a new antibiotic resistance determinant.PLoS One(2011)

Z. Liang, X. Ding, J. Ai, X. Kong, L. Chen, C. Luo, M. Geng, H. Liu, K. Chen, H. Jiang,Discovering potent inhibitors against c-Met kinase: molecular design, organic synthesis and bioassay.Organic & Biomolecular Chemistry,(2011)

Z. Liang, T. Shi, S. Ouyang, H. Li, K. Yu, W. Zhu, C. Luo, H. Jiang,Investigation of the catalytic mechanism of Sir2 enzyme with QM/MM approach: SN1 vs SN2?J Phys Chem B114, 11927-11933 (2010)