苗庆庆，教授、博士生导师
电话：0512-65880052
传真：0512-65884380
电子邮箱：qqmiao@suda.edu.cn
通讯地址：苏州工业园区仁爱路199号,邮编215123
课题组网页：https://www.x-mol.com/groups/QingqingMiao
个人简历：
苗庆庆，www.优德88.cpm 放射医学与防护学院特聘教授，博士生导师，国家重大人才工程A类青年项目入选者，江苏特聘教授，江苏省双创博士人才项目，主持国家自然科学基金青年基金，江苏省青年基金各1项。2010年获得安徽大学化学专业学士学位，2015年获得中国科学技术大学分析化学专业博士学位。2015年至2018年在新加坡南洋理工大学化学与生物医学工程学院完成博士后研究。2018年11月加入www.优德88.cpm 放射医学与辐射防护国家重点实验、放射医学与防护学院分子影像与核医学研究中心。主要从事发展核医学探针、光学探针、纳米技术等用于疾病诊断、治疗及精准医学等的研究。研究领域涉及分子影像，纳米医学，转化医学等交叉领域。迄今为止在Nat. Biotechnol., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv. Mat.等国际核心学术期刊上发表研究论文30多篇。
研究方向：
1.放射性核素探针的设计、合成及其在重大疾病早期诊断、高效治疗等方面的应用基础研究：针对肿瘤高特性靶点和普适性肿瘤微环境开发高性能核素探针；通过合理调控探针的结构，亲疏水性，分子量，自组装等性能参数，调控核素探针的体内行为，提高探针诊疗效果；
2.高灵敏、高特异性探针设计及生物医学应用：针对生物蛋白酶、pH、ROS等与生命活动相关的生物标志物设计激活光学探针，用于肿瘤等疾病的早期诊断。
科研项目：
1.国家自然科学基金面上项目，2023.1-2026.12，54万，主持
2.姑苏创新创业青年领军人才，2021.1-2023.12，50万，主持
3.国家重大人才工程A类青年项目，2020.1-2022.12，200万，主持
4.国家自然科学基金青年项目，2020.1-2022.12，21万，主持
5.2019江苏特聘教授，2019.9-2022.8，100万，主持
6.江苏省青年基金项目，2019.7-2022.6，20万，主持
代表性论著：
1.HuiZhou,Yuan Zhang,Ruru Zhang, Min Zhao, Wan Chen, Yinghua Liu, Yue Jiang,Qing Li,Qingqing Miao*,MinyuanGao*.Tumor Microenvironment-Activatable Molecular Pro-theranostic Agent for Photodynamic and Immunotherapy of Cancer.Adv. Mater.2023, 2211485.
2. Wan Chen, Yue Jiang, Min Zhao, YiAn,Yuan Zhang,Li Yang,Qingqing Miao*.1O2-Relevant Afterglow Luminescence of Chlorin Nanoparticles for Discriminative Detection and Isotopic Analysis of H2O and D2O.Anal. Chem.2023, 95, 5340-5345.
3. Jia Miao#, Minqian Miao#,Yue Jiang, Min Zhao,Qing Li*, Yuan Zhang,YiAn,Kanyi Pu*,Qingqing Miao*. Activatable NIR-II Fluorescent Reporter for in Vivo Imaging of Amyloid-β Plaques.Angew. Chem. Int. Ed.2023, e202216351.
4.Shenhua Li#,Qing Li#,*,Wan Chen,YiAn,Peixin Chen, Yan Wu, GuanglinWang, Yayi He,Qingqing Miao*.A Renal-Clearable Activatable Molecular Probe for Fluoro-Photacoustic and Radioactive Imaging of Cancer.Small, 2022, 2201334.
5. JieliZhu#, Ran Zhu#,Qingqing Miao*. Polymeric agents for activatable fluorescence, self-luminescence and photoacoustic imaging.Biosens.Bioelectron.2022, 210, 114330.
6.Wan Chen,Yuan Zhang,Qing Li*,Yue Jiang,HuiZhou, Yinghua Liu,Qingqing Miao*,MinyuanGao*.Near-Infrared Afterglow Luminescence of Chlorin Nanoparticles for Ultrasensitive In Vivo Imaging.J. Am. Chem. Soc.2022, 144,6719-6726.
7.Yinghua Liu#, Jianfeng Zeng#,Qing Li*, Zhuorun Song, Minqian Miao, Min Zhao,Qingqing Miao*,MinyuanGao*. An APN-activated chemiluminescent probe for image-guided surgery of malignant tumors.Adv. Opt. Mater.2022,2102709.
8. Yuan Zhang#, Guanglin Wang#, Qing Li*, Yue Jiang, Wan Chen, Min Zhao, Gaoling Liang, Qingqing Miao*, Acidity-Activated Charge Conversion of177Lu-labeled Nanoagent for the Enhanced Photodynamic Radionuclide Therapy of Cancer.ACS Appl. Mater. Interfaces, 2022, 14, 3875-3884.
9.Yan Zhang#,*, Shasha He#, Wan Chen, Yinghua Liu, Xuefei Zhang, Qingqing Miao*, Kanyi Pu*. Activatable Polymeric Nanoprobe for Near‐Infrared Fluorescence and Photoacoustic Imaging of T Lymphocytes.Angew. Chem. Int. Ed.,2021, 60, 5921-5927.
10.Wu Cai#, Guohua Fan#, Hui Zhou#, Lei Chen, Jianxian Ge, Baoxing Huang, Dandan Zhou, Jianfeng Zeng*, Qingqing Miao*, Chunhong Hu*. Self-Assembled Hybrid Nanocomposites for Multimodal Imaging-Guided Photothermal Therapy of Lymph Node Metastasis.ACS Appl. Mater. Interfaces, 2020, 12, 49407-49415.
11. Qing Li#, Shenhua Li#, Shasha He, Wan Chen, Penghui Cheng, Yan Zhang,Qingqing Miao*, and Kanyi Pu*. An Activatable Polymeric Reporter for Near-Infrared Fluorescent and Photoacoustic Imaging of Invasive Cancer.Angew. Chem. Int. Ed., 2020, 59, 7018 – 7023 (Cover).
12.Qing Li, Jianfeng Zeng,Qingqing Miao*and Mingyuan Gao. Self-Illuminating Agents for Deep-Tissue Optical Imaging.Front. Bioeng. Biotechnol.2019, 7, 326.
13.Qingqing Miao, and Kanyi Pu*.Organic Semiconducting Agents for Deep‐Tissue Molecular Imaging: Second Near‐Infrared Fluorescence, Self‐Luminescence, and Photoacoustics.Adv. Mater., 2018, 30, 1801778.
14.Qingqing Miao#, David C. Yeo#, Christian Wiraja, Jianjian Zhang, Xiaoyu Ning, Chenjie Xu,* and Kanyi Pu*. Near‐Infrared Fluorescent Molecular Probe for Sensitive Imaging of Keloid.Angew. Chem. Int. Ed., 2018, 57, 1256 –1260.
15. Qingqing Miao, Chen Xie, Xu Zhen, Yan Lyu, Hongwei Duan, Xiaogang Liu, Jesse V Jokerst, and Kanyi Pu*. Molecular afterglow imaging with bright, biodegradable polymer nanoparticles.Nat. Biotechnol., 2017, 35, 1102.
16.Qingqing Miao#, Yan Lyu#, Dan Ding and Kanyi Pu*. Semiconducting oligomer nanoparticles as an activatable photoacoustic probe with amplified brightness for in vivo imaging of pH.Adv. Mater., 2016, 28, 3662-3668.
17.Qingqing Miao, and Kanyi Pu*.Emerging designs of activatable photoacoustic probes for molecular imaging.Bioconjugate Chem., 2016, 27, 2808-2823.
18.Qingqing Miao, Qing Li, Qingpan Yuan, Lingli Li, Zijuan Hai, Shuang Liu, and Gaolin Liang*.Discriminative fluorescence sensing of biothiols in vitro and in living cells.Anal. Chem., 2015, 87, 3460-3466.
19.Qingqing Miao, ZiyeWu, Zijuan Hai, Changlu Tao, Qingpan Yuan, Yadi Gong, Yafeng Guan, Jun Jiang* and Gaolin Liang*.Bipyridine hydrogel for selective and visible detection and absorption of Cd2+.Nanoscale, 2015, 7, 2797-2804.
20.Qingqing Miao, Chunying Yin, Maolin Xie, Yufeng Luo, Zijuan Hai, Qingpan Yuan, Jun Jiang and Gaolin Liang*.Gathering nanorings via Fe2+–bipyridine coordination.Chem. Commun., 2015, 51, 11045-11047.
专利：
1.Polymer nanoparticles for afterglow molecular imaging,US Patent App. 16/633,887, 2021.
2.一种可激活光学分子探针及其制备方法与应用，专利号，ZL 2020 1 0081216.0;
3.一种可区分检测生物硫醇的荧光探针及其制备方法，专利号：ZL 2015 1 0016547.5;
4.一种可检测和去除镉的超分子水凝胶凝胶因子及其制法，专利号：ZL 2014 1 0636033.5;
5.一种单光子发射计算机断层成像显像剂及其制备方法，专利号：ZL 2012 1 0164547.6。
荣誉奖励:
1.海外高层次人才，2020
2.江苏省特聘教授，2019
3.江苏省双创博士，2019
课程教学及招生信息：
本课题组热忱欢迎有志从事科研工作的本科/硕士/博士研究生以及博士后到课题组学习工作。欢迎具有化学、生物和医学背景的同学加盟。如有兴趣，请联系qqmiao@suda.edu.cn。诚挚欢迎各位加入我们课题组!