陈冬，特聘副教授，硕士生导师

电子邮箱：chendong@suda.edu.cn

通讯地址：苏州工业园区仁爱路199号，邮编215123

个人简历：

陈冬，现为www.优德88.cpm 放射医学与防护学院双聘教授，唐仲英血液学研究中心特聘教授，博士生导师，入选国家高层次人才青年项目，姑苏创新创业领军人才计划。2010年获得中国科学技术大学神经生物学博士学位。2015-2020于美国埃默里大学（EMORY UNIVERSITY）从事博士后研究，2021年加入www.优德88.cpm 唐仲英血液学研究中心。长期从事肿瘤的转化医学研究与临床前期研究领域，专注于代谢重编程与白血病等肿瘤发生发展的关系，在Cancer Discovery、Molecular Cell、Cell Chemical Biology等杂志共计发表高质量研究论文14余篇。

研究方向：

1.肿瘤细胞代谢通路的“重编程”与“重布线”的机制

2.代谢物作为信号分子参与调控肿瘤信号通路的机制

3.癌基因在肿瘤生长过程中所需要的特殊“肿瘤代谢物”及其相关机制：

4.肿瘤特异性代谢“重编程”与放疗抵抗的机制

代表性论著：

1.Chen,D.;Gao,F.;Li, B.; Wang, H.; Xu,Y.;Zhu, C.; Wang, G., Parkin mono- ubiquitinates Bcl-2 and regulates autophagy.J Biol Chem2010,285(49),38214-23.

2.Li, B.; Hu,Q.;Xu, R.; Ren, H.; Fei, E.; Chen,D.;Wang, G., Hax-1 is rapidly degraded by the proteasome dependent on its PEST sequence.BMC Cell Biol2012,13,20.

3.Hu,Q.;Li, B.; Xu, R.; Chen,D.;Mu, C.; Fei, E.; Wang, G., The protease Omicleavesthe mitogen-activated protein kinase kinase MEK1 to inhibit microglial activation.Sci Signal2012,5(238), ra61.

4.Gao,F.;Chen,D.;Hu,Q.;Wang, G., Rotenone directly induces BV2 cellactivationvia the p38 MAPKpathway.PLoS One2013,8(8),e72046.

5.Zhou, L.; Wang, H.F.;Ren, H. G.; Chen,D.;Gao,F.;Hu,Q.S.; Fu, C.; Xu, R.J.;Ying, Z.; Wang, G. H., Bcl-2-dependent upregulationofautophagy bysequestosome1/p62 in vitro.Acta Pharmacol Sin2013,34(5),651-6.

6.Yu,Y.X.;Li,Y.P.;Gao,F.;Hu,Q.S.; Zhang,Y.;Chen, D^#.; Wang, G. H^#., VitaminK2suppresses rotenone-induced microglial activation in vitro.Acta Pharmacol Sin2016,37(9), 1178-89.

7.Fan,J.;Lin, R.; Xia, S.; Chen,D.;Elf,S. E.; Liu, S.;Pan,Y.;Xu, H.; Qian, Z.; Wang, M.; Shan, C.; Zhou, L.; Lei,Q. Y.;Li,Y.;Mao, H.; Lee, B. H.; Sudderth,J.;DeBerardinis, R.J.;Zhang, G.; Owonikoko,T.;Gaddh, M.; Arellano, M. L.; Khoury, H.J.;Khuri,F.R.; Kang, S.; Doetsch,P.W.;Lonial, S.; Boggon,T.J.;Curran,W.J.;Chen,J.,TetramericAcetyl- CoA Acetyltransferase 1 Is Important forTumorGrowth.Mol Cell2016,64(5), 859- 874.

8.Lin, R.; Xia, S.; Shan, C.; Chen,D.;Liu,Y.;Gao,X.;Wang, M.; Kang, H. B.;Pan,Y.;Liu, S.; Chung,Y.R.; Abdel-Wahab,O.;Merghoub,T.;Rossi, M.; Kudchadkar, R.R.;Lawson,D.H.; Khuri,F.R.; Lonial, S.; Chen,J.,The Dietary Supplement Chondroitin- 4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells.Mol Cell2018,69(6), 923-937 e8.

9.Chen,D.;Li,Y.P.;Yu,Y.X.;Zhou,T.;Liu, C.; Fei, E. K.; Gao,F.;Mu, C. C.; Ren, H. G.; Wang, G. H., Dendritic cell nuclear protein-1 regulates melatonin biosynthesisbybinding to BMAL1 and inhibiting the transcriptionofN-acetyltransferase in C6 cells.Acta Pharmacol Sin2018,39(4),597-606.

10.Chen,D.;Xia, S.; Wang, M.; Lin, R.; Li,Y.;Mao, H.;Aguiar,M.; Famulare, C.A.;Shih, A. H.; Brennan, C.W.;Gao,X.;Pan,Y.;Liu, S.;Fan,J.;Jin, L.; Song, L.; Zhou,A.;Mukherjee,J.;Pieper,R.O.;Mishra, A.; Peng,J.;Arellano, M.; Blum,W.G.; Lonial,S.;Boggon,T.J.;Levine, R. L.; Chen,J.,Mutant and Wild-TypeIsocitrateDehydrogenase 1 Share Enhancing Mechanisms Involving DistinctTyrosineKinase Cascades inCancer.Cancer Discov2019,9(6),756-777.Preview: Kinase Networks Regulate Metabolism: I'D(H1) Never Have Guessed!Sarah Horton and Brian J.P. Huntly (2019)Cancer DiscoveryDOI: 10.1158/2159-8290.CD- 19-0373.

11.Chen,P.H.; Cai, L.; Huffman, K.;Yang,C.; Kim,J.;Faubert, B.; Boroughs, L.; Ko, B.; Sudderth,J.;McMillan, E. A.; Girard, L.; Chen,D.;Peyton, M.; Shields, M.D.;Yao,B.; Shames,D.S.; Kim, H. S.; Timmons, B.; Sekine, I.; Britt, R.;Weber,S.; Byers, L. A.; Heymach,J.V.;Chen,J.;White, M. A.; Minna,J.D.;Xiao, G.; DeBerardinis, R.J.,Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells.Mol Cell2019,76(5), 838-851 e5.

12.Gao,X.;Zhao, L.; Liu, S.; Li,Y.;Xia, S.; Chen,D.;Wang, M.; Wu, S.; Dai,Q.;Vu, H.;Zacharias, L.; DeBerardinis, R.; Lim, E.; Metallo, C.; Boggon,T.J.;Lonial, S.; Lin, R.; Mao, H.;Pan,Y.;Shan, C.; Chen,J.,gamma-6-Phosphogluconolactone, aByproduct ofthe Oxidative Pentose PhosphatePathway,Contributes to AMPKActivationthrough InhibitionofPP2A.Mol Cell2019,76(6), 857-871e9.

13.Chen,D.;Xia, S.; Zhang, R.; Li,Y.;Famulare, C.;Fan,H.; Wu, R,; Wang, M.; Zhu, A.;Elf,S.; Su, R.; Dong, L.; Arellano, M.; Blum,W.;Mao, H., Lonial, S.; Stock,W.;Odenike,O.;LeBeau, M.; Boggon,T.;He, C.; Chen,J.J.;Gao,X.;Levine, R. L.; Chen,J.,Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells.Mol Cell2021, 81, 3833–3847.

14.Zhang, R^#., Chen, D^#.; Fan,H.; Wu, R.; Li,Y.;Tu,J.;Zhang,F.;Wang,M,; Qu, C.;Elf,S.;Faubert, B.; Xue, G.; DeBerardinis, R.; Chen, J., Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation. Cell Chem Biol 2022，29，1200-1208.