Jia-Bin Li
Jia-Bin Li, Ph.D.
College of Pharmaceutical Sciences
Email:lijiabin@suda.edu.cn
Biosketch
q Education
2005-2009, B.S., Department of Chemistry, University of Science and Technology of China
2009-2015, Ph.D., Department of Chemistry, Tsinghua University
q Work experience
2015-2017, Postdoctoral Fellow, School of Life Sciences, Tsinghua University
2017-2019, Associate Professor, School of Life Sciences, University of Science and Technology of China
2019-present, Associate Professor, College of Pharmaceutical Sciences, Soochow University
q Honors and awards
2020, 16thChinese International Peptide Symposium, Young Peptide Scientist Award
Research Interests
q Using chemical protein synthesis to explore the recognition and catalytic mechanism of histone post-translational modifications, especially ubiquitination and ubiquitin-like modifications, in epigenetic regulation.
q Synthesis and structural modification of pharmaceutical peptides
Research Fund
2022-2025, General Program of National Science Fund, NSFC
2020-2023, General Program of National Science Fund, NSFC
2018-2020, National Science Fund for Young Scholars, NSFC
Select Publications
1 Ai, H.#; Sun, M.#; Liu, A.#; Sun, Z.#; Liu, T.#; Cao, L.; Liang, L.; Qu, Q.; Li, Z.; Deng, Z.; Tong, Z.; Chu, G.; Tian, X.; Deng, H.; Zhao, S.;Li, J.-B.*; Lou, Z.*; Liu, L.* H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity.Nat Chem Biol2022, doi:10.1038/s41589-022-01067-7.
2 Chu, G.-C.#; Pan, M.#;Li, J.#; Liu, S.#; Zuo, C.; Tong, Z.-B.; Bai, J.-S.; Gong, Q.; Ai, H.; Fan, J.; Meng, X.; Huang, Y.-C.; Shi, J.; Deng, H.; Tian, C.*; Li, Y.-M.*; Liu, L.* Cysteine-Aminoethylation-Assisted Chemical Ubiquitination of Recombinant Histones.J Am Chem Soc2019,141(8), 3654–3663.
3 Liang, J.#; Gong, Q.#; Li, Y.; Zheng, Y.; Zheng, J.-S.; Tian, C.*;Li, J.-B.*Thiirane Linkers Directed Histone H2A Diubiquitination Suggests Plasticity in 53BP1 Recognition.Chem Commun2019,55(84), 12639–12642.
4 Li, J.-B.#; Qi, Y.-K.#; He, Q.-Q.; Ai, H.-S.; Liu, S.; Wang, J.-X.; Zheng, J.-S.; Liu, L.; Tian, C.* Chemically Synthesized Histone H2A Lys13 Di-Ubiquitination Promotes Binding of 53BP1 to Nucleosomes.Cell Res2017,28(2), 257-260.
5 Qi, Y.-K.; He, Q.-Q.; Ai, H.-S.; Guo, J.;Li, J.-B.*The Convergent Chemical Synthesis of Histone H3 Protein for Site-Specific Acetylation at Lys56 and Ubiquitination at Lys122.Chem Commun2017,53(29), 4148–4151.