Yanli Liu

Yanli Liu, Ph.D.

Professor

Department of Microbial and Biochemical Pharmacy

Email: ylliu18@suda.edu.cn

Biosketch

q Education

1999-2003B.S. Liaoning Normal University, 2003

2003-2008 Ph.D. Northeast Normal University, 2008

q Work experience

2018 – present: Distinguished Professor, College of Pharmaceutical Sciences,

Soochow University, Suzhou, Jiangsu 215123, P.R. China

2017 – 2017: Visiting Professor, Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada

2012 – 2014: Visiting Scholar, Postdoctoral Fellow, Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada

2009 – 2018 Jun: Lecturer, Associate Professor, College of Life Science, Central China Normal University, Wuhan, Hubei 430079, P.R. China

q Honors and awards

Hubei Chenguang Talented Youth Development Foundation, 2016, Biochemistry and Molecular Biology

Six-talent Professorship of Jiangsu province, 2019, Biotechnology and the new pharmaceutical industry

Third prize of Young Scientists Forum, 2019, National Academic Conference of Biochemistry and Molecular Biology Society

Research Interests

q Structural and Functional Study of Epigenetic Regulation Protein

q Structural and Functional Study of Disease Associated Protein

q Structure Based Drug Design and Screening

Research Fund

q National Natural Science Foundation of China (grant number 32271309), Mechanistic study of PHIP in the recognition of methylated histone H3K4 and discovery of its specific antagonist, 01/2023 to 12/2026, Principal investigator.

q National Natural Science Foundation of China (grant number 31500613), Molecular basis for the recruitment of MLL fusion protein by RNA polymerase II-associated PAF1 complex, 01/2016 to 12/2018, Principal investigator.

q Natural Science Foundation, Hubei Province, P.R. China (grant number 2009CDB234), Role of aquaporin-3 in the lipoatrophy, 12/2009 to 12/2010, Principal investigator.

Select Publications

q Yanli Liu^*,#, Aman Iqbal^#, Weiguo Li^#, Zuyao Ni^#, Yalong Wang^#, Jurupula Ramprasad, Karan Joshua Abraham, Mengmeng Zhang,Dorothy Yanling Zhao,Su Qin, Peter Loppnau,Honglv Jiang, Xinghua Guo,Peter J Brown, Xuechu Zhen, Guoqiang Xu, Karim Mekhail, Xingyue Ji, Mark T. Bedford, Jack F. Greenblatt and Jinrong Min^*, A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II,Nature Communications, 2022, 13:5453,PMID: 36114190.

q Yanli Liu^*, Xiajie Yang, Mengqi Zhou, Yinxue Yang, Fangzhou Li, Xuemei Yan, Mengmeng Zhang, Zhengguo Wei, Su Qin, Jinrong Min^*, Structural basis for the recognition of methylated histone H3 by theArabidopsisLHP1 chromodomain,Journal of Biological Chemistry, 2022, 298(3):101623,PMID: 35074427.

q Renato Ferreira de Freitas^#,Yanli Liu^#, Magdalena M. Szewczyk, Naimee Mehta, Fengling Li, David McLeod, Carlos Zepeda-Velázquez, David Dilworth, Ronan P. Hanley, Elisa Gibson, Peter J. Brown, Rima Al-Awar, Lindsey I. James, Cheryl H. Arrowsmith, Dalia Barsyte-Lovejoy, Jinrong Min, Masoud Vedadi, Matthieu Schapira^*, Abdellah Allali-Hassani^#*, Discovery of small-molecule antagonists of the PWWP domain of NSD2,Journal of Medicinal Chemistry, 2021, 64(3): 1584-1592,PMID: 33522809.

q Mengmeng Zhang^#, Ming Lei^#, Su Qin, Aiping Dong, Ally Yang, Yanjun Li, Peter Loppnau, Timothy R. Hughes, Jinrong Min^*,Yanli Liu^*, Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains,BBA - Gene Regulatory Mechanisms, 2021, 1864(3): 194688,PMID: 33556623.

q Cheng Dong^#,Yanli Liu^#, Tian-Jie Lyu^#, Serap Beldar, Kelsey N. Lamb, Wolfram Tempel, Yanjun Li, Zoey Li, Lindsey I. James, Su Qin^*, Yun Wang^*, Jinrong Min^*, Structural basis for the binding selectivity of human CDY chromodomains,Cell Chemical Biology, 2020, 27(7): 827-838,PMID: 32470319.

q Yanli Liu^#, Su Qin^#, Tsai-Yu Chen^#, Ming Lei^#, Shilpa S. Dhar, Jolene Caifeng Ho, Aiping Dong, Peter Loppnau, Yanjun Li, Min Gyu Lee^*, Jinrong Min^*, Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4,Nature Communications, 2019, 10: 36,PMID: 30604749.

q Yanli Liu, Su Qin, Ming Lei, Wolfram Tempel, Yuzhe Zhang, Peter Loppnau, Yanjun Li, Jinrong Min^*, Peptide recognition by heterochromatin protein 1 (HP1) chromoshadow domains revisited: Plasticity in the pseudosymmetric histone binding site of human HP1,Journal of Biological Chemistry, 2017, 292(14): 5655-5664,PMID: 28223359.

q Yanli Liu, Li Li, Jinrong Min^*,Structural biology:HDAC6 finally crystal clear,Nature Chemical Biology, 2016, 12(9): 660-661,PMID: 27538024.

q Yanli Liu, Wolfram Tempel, Qi Zhang, Xiao Liang, Peter Loppnau, Su Qin^*, Jinrong Min^*, Family-wide characterization of histone binding abilities of human CW domain-containing proteins,Journal of Biological Chemistry, 2016, 291 (17) : 9000-9013,PMID: 26933034.

q Yanli Liu^#, Ke Liu^#, Su Qin, Chao Xu, Jinrong Min^*, Epigenetic targets and drug discovery Part 1: histone methylation,Pharmacology & Therapeutics, 2014, 143 (3) : 275-294,PMID: 24704322.

q Su Qin^#,Yanli Liu^#,Wolfram Tempel, Mohammad S. Eram, Chuanbing Bian, Ke Liu, Guillermo Senisterra, Lissete Crombet, Masoud Vedadi, Jinrong Min^*, Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1,Nature Communications, 2014, 5: 3952,PMID: 24853335.