Haigang Ren

Haigang Ren, Ph.D.

Professor

Department of Pharmacology

Email: rhg@suda.edu.cn

Biosketch

• Education

2001-2005 Southwest University of Science and Technology, B.S.

2005-2010 University of Science and Technology of China, Ph.D.

• Work experience

2010-2012 Southwest University of Science and Technology, Lecturer

2012-2013 Soochow University, Lecturer

2013-2021 Soochow University, Associate Professor

2021-Now Soochow University, Professor

• Honors and awards

2017 Suzhou Science and Technology Progress Award, Second Prize

2021 Suzhou Medical Association Medical Science and Technology Award, First Prize

2021 Acta Pharmacologica Sinica Outstanding Paper Awards

2022 Jiangsu Science and Technology Award, Third Prize

Research Interests

• Pathological mechanism and neuropharmacological research of Parkinson's disease

• Functions and molecular mechanisms of neurodegenerative disease-related proteins

• Screening of small molecule compounds with neuroprotective effect

Research Fund

2022-2025 National Natural Sciences Foundation of China (32170987)

2020-2023 National Natural Sciences Foundation of China (31970966)

2015-2018 National Natural Sciences Foundation of China (31471012)

2012-2014 National Natural Sciences Foundation of China (31100768)

Select Publications

(1) Rui Wang^#; Hongyang Sun^#; Yifan Cao; Zhixiong Zhang; Yajing Chen; Xiying Wang; Lele Liu; Jin Wu; Hao Xu; Dan Wu; Chenchen Mu; Zongbing Hao; Song Qin;Haigang Ren*; Junhai Han*; Ming Fang*; Guanghui Wang*; Glucosylceramide accumulation in microglia triggers STING-dependent neuroinflammation and neurodegeneration in mice,Science Signaling, 2024, 17(829): eadk8249.

全文链接:https://www.science.org/stoken/author-tokens/ST-1774/full

(2) Jin Wu^#; Yingying Han; Hao Xu; Hongyang Sun; Rui Wang;Haigang Ren*; Guanghui Wang*; Deficient chaperone-mediated autophagy facilitates LPS-induced microglial activation via regulation of the p300/NF-κB/NLRP3 pathway,Science Advances, 2023, 9(40): eadi8343.

(3) Le-le Liu^#; Yu Han^#; Zi-jia Zhang^#; Yi-qi Wang; Yu-wei Hu; Elena Kaznacheyeva; Jian-qing Ding; Dong-kai Guo; Guang-hui Wang; Bin Li*;Hai-gang Ren*; Loss of DJ-1 function contributes to Parkinson’s disease pathogenesis in mice via RACK1-mediated PKC activation and MAO-B upregulation,Acta Pharmacologica Sinica, 2023, 44(10): 1948-1961.

(4) Zixuan Lin^#; Chen Chen; Dongqin Yang; Jianqing Ding; Guanghui Wang*;Haigang Ren*; DJ-1 inhibits microglial activation and protects dopaminergic neurons in vitro and in vivo through interacting with microglial p65,Cell Death & Disease, 2021, 12(8): 715.

(5) Rui Wang^#; Hongyang Sun;Haigang Ren*; Guanghui Wang*; α-Synuclein aggregation and transmission in Parkinson's disease: a link to mitochondria and lysosome,Science China-Life Sciences, 2020, 63(12): 1850-1859.

(6) Xingyun Xu^#, Rui Wang^#, Zongbing Hao, Guanghui Wang, Chenchen Mu, Jianqing Ding, Wanping Sun*,Haigang Ren*, DJ-1 regulates tyrosine hydroxylase expression through CaMKKβ/CaMKIV/CREB1 pathway in vitro and in vivo,Journal of Cellular Physiology, 2020, 235(2):869-879.

(7) Dong-Kai Guo^#; Yao Zhu^#; Hong-Yang Sun; Xing-Yun Xu; Shun Zhang; Zong-Bing Hao; Guang-Hui Wang; Chen-Chen Mu;Hai-Gang Ren*; Pharmacological activation of REV-ERBα represses LPS-induced microglial activation through the NF-κB pathway,Acta Pharmacologica Sinica, 2019, 40(1): 26-34.

(8) Dongkai Guo^#; Shun Zhang; Hongyang Sun; Xingyun Xu; Zongbing Hao; Chenchen Mu; Xingshun Xu; Guanghui Wang*;Haigang Ren*; Tyrosine hydroxylase down-regulation after loss of Abelsonhelper integration site 1 (AHI1) promotes depression via the circadian clock pathway in mice,Journal of Biological Chemistry, 2018, 293(14): 5090-5101.

(9) Dong Chen^#; Yi-Pei Li^#; Yan-Xia Yu; Tian Zhou; Chao Liu; Er-Kang Fei; Feng Gao; Chen-Chen Mu;Hai-Gang Ren*; Guang-Hui Wang*; Dendritic cell nuclear protein-1 regulates melatonin biosynthesis by binding to BMAL1 and inhibiting the transcription of N-acetyltransferase in C6 cells,Acta Pharmacologica Sinica, 2018, 39(4): 597-606.

(10) Kai Fu^#; Yanfei Wang^#; Dongkai Guo; Guanghui Wang*;Haigang Ren*; Familial Parkinson's Disease-Associated L166P Mutant DJ-1 is Cleaved by Mitochondrial Serine Protease Omi/HtrA2,Neuroscience Bulletin, 2017, 33(6): 685-694.

(11)Haigang Ren^#; Kai Fu; Chenchen Mu; Xuechu Zhen; Guanghui Wang*; L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL,Molecular Neurodegeneration, 2012, 7:40.

(12)Haigang Ren^#, Kai Fu; Dan Wang; Chenchen Mu; Guanghui Wang*; Oxidized DJ-1 interacts with the mitochondrial protein BCL-XL,Journal of Biological Chemistry, 2011, 286(40): 35308-35317.

(13)Haigang Ren^#; Kai Fu; Chenchen Mu; Bin Li; Dan Wang; Guanghui Wang*; DJ-1, a cancer and Parkinson's disease associated protein, regulates autophagy through JNK pathway in cancer cells,Cancer Letters, 2010, 297(1): 101-108.