Yuan Wang

Yuan Wang, Ph.D.

Assistant Professor

Department of Pharmacology

Email: yuanw@suda.edu.cn

Biosketch

q Education

2002/9-2009/6 PhD in Shanghai Institute for Biological sciences, Chinese Academy of Sciences

1998/9-2002/7 BSc in Department of Biology Science and Technology, The Northeast Normal University of China

q Work experience

2016/9-current Assistant professor, Pharmacology College of Soochow University

2015/3-2016/9 Research associate, University of Pennsylvania, School of medicine

2010/3-2015/2 Post-doctoral research fellow inUniversity of Pennsylvania

q Honors and awards

2012/10 Aegean Conference Award of XXIV International Complement Workshop

2012/01 AHA GRA Summer 2011 Postdoctoral Fellowship

2007/07 Excellent student honor of CAS

2005/10 Excellent student honor of CAS

2002/09 Rector scholarship of CAS

Research Interests

q Molecular mechanisims of brain tumor development and the involvment of tumor microenvironment

q New targets of brain tumor therapy

Research Fund

(1) 2021/01-2024/12,National Natural Science Foundation of China, general project, 82073873, The source, function and trans-differentiation mechanisms of astrocytes in medulloblastoma relapse.

(2) 2018/01- 2020/12, National Natural Science Foundation of China, young scientist project, 81703538, Astrocytes promote medulloblastoma progression through secreting Shh.

(3) 2017/07 – 2020/06Natural Science Foundation of Jiangsu province, young scientist project, BK20170348, Complement C3a contributes to medulloblastoma development and the mechanisims study.

Select Publications

(1) Biao Gong #, Duancheng Guo #, Chaonan Zheng, Zhen Ma, Jie Zhang, Yanghui Qu, Xinhua Li, Gen Li, Li Zhang, Yuan Wang; Complement C3a activates astrocytes to promote medulloblastoma progression through TNF‑α, Journal of Neuroinflammation，2022, Jun 20;19(1):159. (IF: 8.322)

(2)Qinglin Wang; Hao Wu; Jian Hu; Haijuan Fu; Yanghui Qu; Yijun Yang; Kathy Q. Cai; Andrey Efimov; Minghua Wu; Tim Yen;Yuan Wang*; Zeng-Jie Yang* ; Nestin is required for spindle assembly and cell cycle progression in glioblastoma cells, Molecular Cancer Research, 2021, 19(10): 1651-1665 (IF: 5.852)

(3) Duancheng Guo; Yuan Wang; Yan Cheng; Shengyou Liao; Jian Hu; Fang Du; Gang Xu; Yongqiang Liu; Kathy Q. Cai; Martin Cheung; Brandon J. Wainwright; Q. Richard Lu; Yi Zhao; Zeng-jie Yang ;Tumor cells generate astrocyte-like cells that contribute to SHH-driven medulloblastoma relapse,Journal of Experimental Medicine, 2021, 218(9): e20202350 (IF: 14.307)

(4) Yongqiang Liu; Larra W. Yuelling; Yuan Wang; Fang Du; Renata E. Gordon; Jenny A. O'Brien;Jessica M.Y. Ng; Shannon Robins; Eric H. Lee; Hailong Liu; Tom Curran; Zeng-Jie Yang ; Astrocytes promote medulloblastoma progression through hedgehog secretion, Cancer Research, 2017, 77(23): 6692-6703 (IF: 8.576)

(5) Yuan Wang; Takashi Miwa; Blerina Ducka-Kokalari; Imre G. Redai; Sayaka Sato; Damodar Gullipalli; ames G. Zangrilli; Angela Haczku; Wen-Chao Song ; Properdin contributes to allergic airway inflammation through local C3a generation, Journal of Immunology, 2015, 195(3): 1171-81 (IF: 5.362)

(6) Yuan Wang; Kairui Mao; Shuhui Sun; Guomei Lin; Xiaodong Wu; Gang Yao; Bing Sun ; Trichosanthin functions as Th2-type adjuvant in induction of allergic airway inflammation, Cell Research,2009, 19(8): 962-72 (IF: 12.413)

(7) Cheng Y, Liao S, Xu G, Hu J, Guo D, Du F, Contreras A, Cai KQ, Peri S, Wang Y, Corney DC, Noronha AM, Chau LQ, Zhou G, Wiest DL, Bellacosa A, Wechsler-Reya RJ, Zhao Y, Yang ZJ. NeuroD1 Dictates Tumor Cell Differentiation in Medulloblastoma. Cell Rep. 2020 Jun 23;31(12) (IF: 8.109)

(8) Cheng Y, Franco-Barraza J, Wang Y, Zheng C, Zhang L, Qu Y, Long Y, Cukierman E, Yang ZJ. Sustained hedgehog signaling in medulloblastoma tumoroids is attributed to stromal astrocytes and astrocyte-derived extracellular matrix. Lab Invest. 2020 Sep;100(9)（IF: 4.197）

(9) Fang Du, Larra Yuelling, Eric H. Lee,Yuan Wang, Shengyou Liao,Yan Cheng, Li Zhang, Chaonan Zheng,Suraj Peri,Kathy Q.Cai, Jessica M.Y.Ng,TomCurran, Peng Li, and Zeng-jie Yang, Leukotriene synthesis is critical for medulloblastoma progression. Clinical Cancer Research. 2019 25(21): 6475-6486 (IF: 10.199)

(10) Wang X, Van Lookeren Campagne M, Katschke KJ Jr, Gullipalli D, Miwa T, Ueda Y, Wang Y, Palmer M, Xing G, Song WC. Prevention of Fatal C3 Glomerulopathy by Recombinant Complement Receptor of the Ig Superfamily. J Am Soc Nephrol. 2018 Aug (IF: 8.966)

(11) Yoshiyasu Ueda, Imran Mohammed, Delu Song, Damodar Gullipalli, Lin Zhou, Sayaka Sato, Yuan Wang, Shuchi Gupta, Zhongjian Cheng, Hong Wang, Jialing Bao, Yingying Mao, Lawrence Brass, X. Long Zheng, Takashi Miwa, Matthew Palmer, Joshua Dunaief and Wen-chao Song. Murine systemic thrombophilia and hemolytic uremic syndrome from a factor H point mutation. (Blood. 2017 Mar 2) (IF: 11.841)