Name, Ph.D.
Professor
Department of Pharmacology
Email: wanggh@suda.edu.cn
Biosketch
q Education
1981.9-1987.7
1987.9-1990.7
1997.4-2001.3 University of
q Training
2005.10-2007.3 University of
2001.4-2001.11
2001.12-2003.8 University of
q Work experience
1990.8-1993.7 Assistant Professor, Department of Histology and Embryology, Shanghai Medical University, Shanghai, China
1993.8-1995.9 Lecturer, Department of Histology and Embryology, Shanghai Medical University, Shanghai, China
2003.9-2011.9 Professor, Department of Neurobiology, University of Science and Technology of China, China
2011.10-now Professor, Department of Pharmacology, Soochow University, China
q Honors and awards
Hundred-Talent Program ofthe Chinese Academy of Sciences, 2004
Special President’s Award of the Chinese Academy of Sciences, 2011
Jiangsu Science and Technology Progress Award (Second prize), 2019
q Social Activity
Chair of the devision “Neuroglial cell” of Chinese Neuroscience Society.
Associate Editor of Frontiers in Aging Neuroscience
Editor of Neuroscience Bulletin
Editor of Aging and Neurodegenerative diseases
Editor of Exploration of Neuroprotective Therapy
Research Interests
q Molecular basis of neurodegenerative diseases
q Neurodegeneration in association with neuroinflammation
q Protein property and quality control in neurodegenerative diseases
Research Fund
q National Natural Sciences Foundation of China (32070970)2021.1-2024.12
Kinase screening of mitochondrial PINK1 accumulation and the protective effects on dopaminergic neurons in Parkinson’s disease models
Role: PI
q National Natural Sciences Foundation of China (31871023) 2019.1-2022.12
Effects of mitochondrial metabolism and reactive oxygen species (ROS)production onmicroglial activation in Parkinson's disease
Role: PI
q National Natural Sciences Foundation of China (81761148024) 2017.1-2019.12
Screen and identification of small molecule compounds effective on Parkinson’s disease.
Role: PI
q National Key Scientific R&D Program of China (2016YFC1306002) 2016.6-2020.12
The role of genetic, environmental, and aging factors and their interactions in the mechanism of Parkinson's disease
Role: PI
q National Natural Sciences Foundation of China (31330030) 2014.1-2018.12
The activation of microglia by genetic and environmental factors in association with Parkinson disease
Role: PI
q National Natural Sciences Foundation of China (81371393) 2014.1-2017.12
The role of new substrate of Parkinson's disease-realted proteon parkin in mitophagy
Role: PI
q National Key Scientific R&D Program of China (2012CB947602) 2012.5-2016.7
Regulatory mechanism of circadian clock on hypothalamic GnRH network
Role: PI
q National Natural Sciences Foundation of China (91132723) 2012.1-2014.12
The role of schizophrenia-related protein dysbindin on neurodevelopment and pathogenesis
Role: PI
Select Publications
1． Lin, Z., Chen, C., Yang, D., Ding, J.,Wang, G*. and Ren, H*., DJ-1 inhibits microglial activation and protects dopaminergic neurons in vitro and in vivo through interacting with microglial p65.Cell Death Dis2021; 12 (8): 715.
2． Gao F., Zhang Y., Hou X., Tao Z., Ren H., andWang G*. Dependence of PINK1 accumulation on mitochondrial redox system.Aging Cell,2020; 19(9):e13211.
3． Hao Z, Liu L, Wang R, Ren H, Sun H, Lin Z, Zhang Z, Mu C, Zhou J,Wang G*. Motor dysfunction and neurodegeneration in a C9orf72 mouse line expressing poly-PR,Nat Commun,2019;10: 2906.
4． Guo D, Zhang S, Sun H, Xu X, Hao Z, Mu C, Xu X,Wang G*, Ren H*, Tyrosine hydroxylase down-regulation after loss of Abelson helper integration site 1 (AHI1) promotes depression via the circadian clock pathway in mice.J Biol Chem2018; 293: 5090-5101.
5． Gu C, Zhang Y, Hu Q, Wu J, Ren H, Liu CF,Wang G*. P7C3 inhibits GSK3β activation to protect dopaminergic neurons against neurotoxin-induced cell death in vitro and in vivo.Cell Death Dis2017; 8(6):e2858
6． Mao J, Xia Q, Kiu C, Ying Z, Wang H*,Wang G*. A Critical role of Hrd1 in the regulation of optineurin degradation and aggresome formation,Hum Mol Genet2017; 26:1877-89.
7． Xia Q, Wang H, Hao Z, Fu C, Hu Q, Gao F, Ren H, Chen D, Han J, Ying Z*,Wang G*. TDP-43 loss of fuction increases TFEB activity and blocks autophagosome-lysosome fusion.EMBO J2016; 35:121-142.(Cover story)
8． Xia Q, Wang H, Zhang Y, Ying Z*,Wang G*. Loss of TDP-43 Inhibits Amyotrophic Lateral Sclerosis-Linked Mutant SOD1 Aggresome Formation in an HDAC6-Dependent Manner.J Alzheimers Dis2016; 45:373-386.
9． Yang Z, Xia Q, Hao Z, Xu D, Wang M, Wang H*,Wang G*. TARDBP/TDP-43 regulates autophagy in both MTOC1-dependent and MTOC1-independent manners.Autophagy2016; 12:707-8.
10． Tao Z, Wang H, Xia Q, Li K, Li K, Jiang X, Xu G,Wang G*, Ying Z*. Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity.Hum Mol Genet2015, 24: 2426-41
11． Gao F, Chen D,SiJ,HuQ,FangM andWang G*.Impairment of Nix-mediated mitophagy is linked to the pathogenesis of Parkinson's disease.Hum Mol Genet2015, 24: 2528-38
12． Xia Q, Hu Q, Wang H, Yang H, Gao F, Ren H, Chen D, Fu C, Zheng L, Zhen X, Ying Z* andWang G*. Induction of COX-2-PGE2 synthesis by activation of the MAPK/ERK pathway contributes to neuronal death triggered by TDP-43-depleted microglia.Cell Death Dis2015; 6: e1702.
13． Zhou L, Wang H, Ren H, Hu Q, Ying Z*,Wang G.*Bcl-2 Decreases the Affinity of SQSTM1/p62 to Poly-Ubiquitin Chains and Suppresses the Aggregation of Misfolded Protein in Neurodegenerative Disease.Mol Neurobiol2015,52:1180-1189
14．
Xu R, Hu Q, Ma Q, Liu C,Wang G*.The protease Omi regulates mitochondrial biogenesis through the GSK3b/PGC
15． Ren H, Fu K, Mu C, Zhen X,Wang G*.L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL.Mol Neurodegener2012, 7:40.
16． Hu Q, Li B, Xu R, Chen D, Mu C, Fei E,Wang G*The Protease Omi Cleaves the Mitogen-Activated Protein Kinase Kinase MEK1 to Inhibit Microglial Activation.Sci Signal2012,5:ra61.(Cover story)
17． Wang H, Ying Z,Wang G* Ataxin-3 Regulates Aggresome Formation of Copper-Zinc Superoxide Dismutase (SOD1) by Editing K63-linked Polyubiquitin Chains.J Biol Chem2012, 287:28576-28585.
18． Ren H, Fu K, Wang D, Mu C,Wang G*Oxidized DJ-1 interacts with the mitochondrial protein BCL-XL.J Biol Chem2011,.
19． Fu K, Ren H, Wang Y, Fei E, Wang H,Wang G*DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD.Oncogene2011, 31:1311-1322.
20． Ma X, Fei E, Fu C, Ren H,Wang G*Dysbindin-1, a schizophrenia-related protein, facilitates neurite outgrowth by promoting the transcriptional activity of p53.Mol Psychiatry2011, 16:1105-1116.(Cover story)
21． Ying Z, Wang H*, Fan H,Wang G*The ER-associated degradation system regulates aggregation and degradation of mutant neuroserpin.J Biol Chem2011, 286: 20835-20844.
22． Fei E, Ma X, Zhu C, Xue T, Yan J, Xu Y, Zhou J,Wang G* Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia related protein, regulates synapsin I expression.J Biol Chem2010285：38630-38640.
23． Chen D, Gao F, Li B, Wang H, Xu Y, Zhu C, Wang G* Parkin mono-ubiquitinates BCL-2 and regulates autophagy.J Biol Chem2010, 285: 38214-38223
24． Li B, Hu Q, Wang H, Man N, Ren H, Wen L, Nukina N, Fei N,Wang G*Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases.Cell Death Differ2010,17:1751-1759
25． Zhou T, Wang S, Ren H, Qi X, Luchetti S, Kamphuis W, Zhou J,Wang G* and Swaab D* Dendritic cell nuclear protein-1, a novel depression-related protein, upregulates corticotropin-releasing hormone expression.Brain2010, 133: 3069-3079
26． Ying Z, Wang H, Fan H, Zhu X, Zhou J, Fei E,Wang G*. Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation.Hum Mol Genet2009,9: 1795-180
27． Fan J, Ren H, Jia N, Fei E, Zhou T, Jiang P, Wu M,Wang G*. DJ-1 Decreases Bax Expression through Repressing p53 Transcriptional Activity.J Biol Chem2008,283:4022-4030
28． Liu C, Fei E, Jia N, Wang H, Tao R, Iwata A, Nukina N, Zhou J, andWang G*.Assembly of lysine 63 linked ubiquitin-conjugates by phosphorylated alpha-synuclein implies Lewy body biogenesis.J Biol Chem2007,282:14558-14566
Address: Yunxuan building, phase II, Dushu Lake campus, Suzhou University
No. 199, Ren'ai Road, Suzhou Industrial Park, Suzhou, Jiangsu, China
Email: pharm@suda.edu.cn
Tel: 0512-65882089
