Jian Zhang

Jian Zhang, Ph.D.

Associate Professor

Department of traditional Chinese medicine

Email: jianzhang@suda.edu.cn

Biosketch

q Education

09/2000-06/2003 Ph.D., Traditional Chinese Pharmacy, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, PR China

09/1997-07/2000 M. S., Traditional Chinese Medicine, College of Pharmacy, Heilongjiang University of Chinese Medicine, Haerbin, PR China

09/1993-07/1997 B. A., Traditional Chinese Medicine, Department of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Haerbin, PR China

q Work experience

06/2006-Associate Professor, College of Pharmaceutical Science, Soochow University, Suzhou, PR China

11/2014-11/2015 Visiting Scholar, Natural Products Research Laboratories, University of North Carolina at Chapel Hill, USA

07/2012-10/2012 Visiting Scholar, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong

08/2003-05/2006 Lecturer, College of Pharmaceutical Science, Soochow University, Suzhou, PR China

q Honors and awards

Teaching Awards of Bank of Communications, Soochow University, 2012

My favorite teacher in the medical department, Soochow University, 2018

Research Interests

q Anticomplementactive constituent,antithrombotic active constituent, antitumor active constituent and anti-HIV active constituent from medicinal plants

q Preventive effect and active constituent of medicinal plants against lung injury

Research Fund

1.Research on the application of key technologies for efficient green processing and quality control of Biluochun black tea, supported by the Suzhou science and technology plan project, SNG2021022, RMB 100,000, 2021.7-2024.6

2.Study on antithrombosis constituent of Campsis radicans, supported by the Suzhou Plication Fundamental Research Program, SYS201522, RMB 30,000, 2015.7-2018.6

3.Study on heat clearing and detoxicating material basis for the efficacy of Eupatorium lindleyanum, supported by the Natural Science Foundation of China, 81202882, RMB 240,000, 2013.1-2015.12.

4.Study on chemical constituents and its mechanism of Eupatorium lindleyanum on protecting acute lung injury, supported by the Natural Science Foundation of Jiangsu Province, BK2011296, RMB 80,000, 2011.7-2014.7.

5.Study on anticomplement constituent of Rabdosia japonica var. glaucocalyx (Maxin.) Hara, supported by the Jiangsu Province College Natural Science Fundation, 10KJB350004, RMB 30,000, 2010.1-2012.12.

Select Publications

1.Meng Li^#, Yadong Cui^#, Mei Zhu, Xiaolei Huang,Faiz Ur Rehman,Jingwen Wang, Lixiao Zhang^a, Tianwen Liu^a, Jiangyun Liu^a, Junye Lu^b, Xiaogang Jiang^*,Jian Zhang^*.Isolation and characterization of secondary metabolites from the leaves ofSauropus spatulifoliusBeille and their potential biological assays. Fitoterapia. 2022, 156: 105100. DOI: 10.1016/j.fitote.2021.105100

2.Qi-Run Li^#, Yung-Yi Cheng^#, Lei Zhao^#, Xiao-Lei Huang, Xiao-Gang Jiang, Ya-Dong Cui, Susan L. Morris-Natschke, Masuo Goto, Chin-Ho Chen, Kuo-Hsiung Lee*, Dao-Feng Chen*,Jian Zhang*. New Phorbol Ester Derivatives as Potent Anti-HIV Agents.Bioorganic & Medicinal Chemistry Letters.2021, 50: 128319.DOI: 10.1016/j.bmcl.2021.128319.

3.Lei Zhao, Ziyan Qi, Ling Yi, Jingjing Li, Yadong Cui, Faiz Ur Rehman, Jianhua Yang, Jiangyun Liu, Yali Li*,Jian Zhang*. The interaction between gut microbiota and flavonoids extract from Smilax glabra Roxb. and its potent alleviation of fatty liver,Food & Function,2021, 12, 7836-7850. DOI: 10.1039/D1FO00727K

4.Xiaolei Huang^#, Jinglei Chen^#, Xianlun Li, Lei Zhao, Yadong Cui, Jiangyun Liu, Susan L. Morris-Natschke, Goto Masuo, Yungyi Cheng, Kuo-Hsiung Lee*, Daofeng Chen*,Jian Zhang*.Synthesis and in vitro anticancer activities of biotinylated derivatives of glaucocalyxin A and oridonin.Journal of Asian Natural Product Research. 2021, 23 (7): 703-711.DOI:10.1080/10286020.2020.1760851.

5.Yanmei Li^#, Lei Zhao^#, Xiaolei Huang^#, Liguang Zhang, Jingjing Li,Jian Zhang^*. Preparation of eicosapentaenoic acid ethyl ester from fish oil ethyl esters by continuous batch chromatography.Journal of Separation Science.2019, 42 (24): 3697-3702.DOI:10.1002/jssc.201900387

6.Xiaolei Huang^#, Xiaochen Wei^#, Lengqiu Guo^#, Lei Zhao, Xihua Chen, Yadong Cui, Jie Yuan, Daofeng Chen,Jian Zhang*. The therapeutic effects of Jaceosidin on lipopolysaccharide-induced acute lung injury in mice.Journal of Pharmacological Sciences. 2019,140 (3): 228-235.DOI: 10.1016/j.jphs.2019.07.004.

7.Kaidi Su^#, Yanmei Li^#, Xiaolei Huang, Lei Zhao, Qirun Li, Meng Li, Heran Li^*,Jian Zhang^*.Complexion ofKadsura coccineaextract with cyclodextrin: characterization, thermal stability, antioxidative propertiesin vitroand the protective effects on kidney damage.Journal of Inclusion Phenomena and Macrocyclic Chemistry.2018, 91 (3-4):141-148.DOI: 10.1007/s10847-018-0804-2.

8.Xiaochen Wei^#, Yanmei Li^#, Meng Li^#, Chunyan Min, Hui Lu, Qirun Li, Jie Yuan, Chen Chen, Heran Li,Jian Zhang*,The protective effects ofSauropus spatulifoliuson acute lung injury induced by lipopolysaccharide.Journal of the Science of Food and Agriculture. 2018,98 (12):4420-4426. DOI:10.1002/jsfa.8964.

9.Liang Xu, Kaidi Su, Xiaochen Wei,Jian Zhang*, Heran Li*.Chemical constituents ofKadsura coccinea.Chemistry of Natural Compounds. 2018, 54 (2): 242-244. DOI:10.1007/s10600-018-2313-3.

10.Qun Sun^#, Naiyu Xu^#, Qirun Li^#, Shi Yao, Meng Li, Heran Li*,Jian Zhang*, Daofeng Chen. Antiglycemic and anticomplementary potential of an edible plantGnaphalium hypoleucumDC.Journal of Functional Foods.2017, 38: 321-328.DOI: 10.1016/j.jff.2017.09.006.

11.Chunjun Chu^#, Shi Yao^#, Jinglei Chen, Xiaochen Wei, Long Xia, Daofeng Chen*,Jian Zhang*.Eupatorium lindleyanumDC. flavonoids fraction attenuates lipopolysaccharide-induced acute lung injury in mice. International Immunopharmacology.2016, 39: 23-33. DOI: 10.1016/j.intimp.2016.06.032.

12.Chunjun Chu, Huiling Ren, Naiyu Xu, LongXia, Daofeng Chen*,Jian Zhang*.Eupatorium lindleyanumDC. sesquiterpenes fraction attenuates lipopolysaccharide-induced acute lung injury in mice. Journal of Ethnopharmacology. 2016, 185: 263-271. DOI: 10.1016/j.jep.2016.03.022.

13.Meihua Han, Zhitao Li, Yifei Guo,Jian Zhang*, Xiangtao Wang*. A nanoparticulate drug-delivery system for glaucocalyxin A: formulation, characterization, increased in vitro, and vivo antitumor activity. Drug Delivery. 2016, 23 (7): 2457-2463. DOI: 10.3109/10717544.2015.1012311.

14.Naiyu Xu, Chunjun Chu, Long Xia,Jian Zhang*, Daofeng Chen*.Protective effects ofRabdosia japonicavar.glaucocalyxextract on lipopolysaccharide-induced acute lung injury in mice. Chinese Journal of Natural Medicines. 2015, 13 (10): 767-775. DOI:10.1016/S1875-5364(15)30077-7.

15.Ping Gan^#,Li Zhang^#, Yanke Chen, Yu Zhang, Fali Zhang, Xiang Zhou, Xiaohu Zhang, Bo Gao, Xuechu Zhen,Jian Zhang**, Longtai Zheng*. Anti-inflammatory effects of glaucocalyxin B in microglia cells. Journal of Pharmacological Sciences. 2015, 128: 35e46. DOI: 10.1016/j.jphs.2015.04.005.