Zheng Ying

Zheng Ying, Ph.D.

Professor

Department of Pharmacology

Email: zheng.ying@suda.edu.cn

Biosketch

q Education

2004-2009 University of Science and Technology of China

Ph.D. in Neurobiology, November 2009

2000-2004 University of Science and Technology of China

B.S. in Bioscience, July 2004

q Work experience

2016-present Professor

Department of Pharmacology, Soochow University College of Pharmaceutical Sciences

2012-2016 Associate Professor

Department of Pharmacology, Soochow University College of Pharmaceutical Sciences

2010-2012 Postdoctoral Research Associate with Dr. Arthur Horwich

Yale University School of Medicine / Howard Hughes Medical Institute (HHMI)

2004-2009Ph.D. Student with Dr. Guanghui Wang

Laboratory of Molecular Neuropathology, Department of Neurobiology, School of Life Sciences, University of Science and Technology of China

q Honors and awards

2017 CNPHARS-SERVIER Young Investigator Awards in Pharmacology

2010 Qiu Shi Graduate Student Scholarship by Hong Kong Qiu Shi Science & Technologies Foundation

Research Interests

Increasing evidence indicates thatfurther exploration of cellular quality control system is critical for understanding the basic mechanism underlying neurodegenerative disorders including amyotrophic lateral sclerosis, Parkinson’s disease and Alzheimer’s disease. The goal of our studies is to describe howprotein, organelle andmembrane-less organellequality control systems, including ubiquitin-proteasome system, autophagy andbiomolecular condensation machinery,fail to protect neurons at disease stages. To this end,we will use cell biology, molecular biology, biochemical approaches and genetic manipulation of animal models to investigate the relationship between these quality control systems and neurodegeneration.

Research Fund

2021-2023 National Natural Science Fund for Excellent Young Scientists (82022022)

Select Publications

1. Li N, Sun S, Ma G, Hou H, Ma Q, Zhang L, Zhang Z*, Wang H*,Ying Z* (2022). Gefitinib facilitates PINK1/Parkin-mediated mitophagy through enhancing mitochondrial recruitment of OPTN.Fundamental Research. 2022 Mar 3. doi.org/10.1016/j.fmre.2021.12.017.

2. Zhang Y¹, Fang Q¹, Wang H, Qi J, Sun S, Liao M, Wu Y, Hu Y, Jiang P, Cheng C, Qian X, Tang M, Cao W, Xiang S, Yang J, Gao X*,Ying Z*, Chai R* (2022). Increased mitophagy protects cochlear hair cells from aminoglycoside-induced damage.Autophagy. 2022 Apr 26:1-17. doi: 10.1080/15548627.2022.2062872.

3. Wang H¹, Wang N¹, Xu D1, Ma Q, Chen Y, Xu S, Xia Q, Zhang Y, Prehn JHM, Wang G,Ying Z* (2020). Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis.Autophagy. 16(9):1683-1696.

4. Wang M¹, Wang H¹, Tao Z, Xia Q, Hao Z, Prehn JHM, Zhen X, Wang G*,Ying Z* (2020).C9orf72 associates with inactive RRAG GTPases and regulates MTORC1-mediated autophagosomal and lysosomal biogenesis.Aging Cell. 19(4):e13126.

5. Xia Q, Wang H, Hao Z, Fu C, Hu Q, Gao F, Ren H, Chen D, Han J,Ying Z* and Wang G*(2016).TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion.EMBO J.35(2):121-42. Notes: Cover story and highlighted in News & Views in this issue.

(¹Co-first author) (*Corresponding author)