Haidong Xu

Haidong Xu, Ph.D./M.D

Instructor

Department of Pharmacology

Email: hdxu01@suda.edu.cn

Biosketch

q Education

2009-2012 College of Pharmaceutical Sciences, Soochow University

2001-2004 Nanjing University of Chinese Medicine

1995-2000 Henan University of Chinese Medicine

q Work experience

2016-2019 Department of Pharmacology, Emory University School of Medicine

2006-2007 Institute of Zoology, Chinese Academy of Science

Research Interests

q I am interested in the endosomal-lysosomal pathways including autophagy in neuronal stress response and their roles in neurodegenerative disease, particularly Alzheimer’s disease and Parkinson’s disease.

Select Publications

Xu Haidong, Liu Xiaolei, Li Wenming, Xi Ye, Su Peng, Meng Bo, Shao Xiaoyun, Tang Beisha, Yang Qian, Mao Zixu. p38 MAPK-mediated loss of nuclear Rnase III enzyme Drosha underlies amyloid beta-induced neuronal stress in Alzheimer’s disease,Aging Cell, 2021, 20(10): e13434.

Lu Ting, Zhu Zhou, Wu Junchao, She Hua, Han Rong,Xu Haidong*, Qin Zheng-Hong*. DRAM1 regulates autophagy and cell proliferation via inhibition of the phosphoinositide 3-kinase-Akt-mTOR-ribosomal protein S6 pathway,Cell Communication and Signaling, 2019, 17(1):28.

Wu Feng^#,Xu Haidong^#, Guan Junjie, Hou Yisheng, Gu Jinhua, Zhen Xuechu, Qin Zheng-Hong. Rotenone impairs autophagic flux and lysosomal functions in Parkinson’s disease,Neuroscience, 2015, 284:900-911.

Xu Haidong, Wu Dan, Gu Jinhua, Ge Jianbin, Wu Junchao, Han Rong, Liang Zhongqin, Qin Zheng-Hong. The pro-survival role of autophagy depends on Bcl-2 under nutrition stress conditions,Plos One, 2013, 8(5):e63232.

Xu Haidong, Qin Zheng-Hong. Beclin 1, Bcl-2, and autophagy,Advances in Experimental Medicine and Biology, 2019, 1206:109-126.