Hongfeng Wang
Hongfeng Wang, Ph.D.
Professor
Department of Pharmacology
Email: wanghongfeng@suda.edu.cn
Biosketch
q Education
2004-2009University of Science and Technology of China
Ph.D. in Neurobiology, June 2009
2000-2004 University of Science and Technology of China
B.S. in Bioscience, June 2004
q Work experience
2020-present Professor
Department of Pharmacology, Soochow University College of Pharmaceutical Sciences
2013-2020 Associate Professor
Department of Pharmacology, Soochow University College of Pharmaceutical Sciences
2012-2013 Postdoctoral Research Associate with Dr. Angus Nairn
Yale University School of Medicine, Department of Phychiatry
2011-2013Postdoctoral Research Associate with Dr. Guanghui Wang
Department of Pharmacology, Soochow University College of Pharmaceutical Sciences
2009-2010Postdoctoral Research Associate with Dr. Guanghui Wang
School of Life Sciences, University of Science and Technology of China
Research Interests
q Pathogenesis studies of neurological disorders and potential therapeutic targets
q Protein quality control in neurodegenerative diseases
Research Fund
1. National Natural Science Foundation of China，82071274，1/2021-12/2024, Mechanism underlying amino acid-induced mTORC1 signaling in SCA3/MJD pathogenesis
2. National Natural Science Foundation of China，31771117，1/2018-12/2021, The regulation of mitophagy by a deubiquitinating enzyme ataxin-3
3. National Natural Science Foundation of China，31371072，1/2014-12/2017, The role of deubiquitin enzyme ataxin-3 in mitochondrial dysfunction and the pathogenesis of neurodegenerative disease
4. National Natural Science Foundation of China，31000473，1/2010-12/2013, The Ataxin-3-mediated K63-linked deubiquitination targets misfolded proteins to aggresomes
Select Publications
1. Wang M1,Wang H1, Tao Z, Xia Q, Hao Z, Prehn JHM, Zhen X, Wang G*, Ying Z* (2020). C9orf72 associates with inactive RRAG GTPases and regulates MTORC1-mediated autophagosomal and lysosomal biogenesis.Aging Cell. 19(4):e13126.
2. Zhang Z1, Wang N1, Ma Q, Chen Y, Yao L, Zhang L, Li Q, Shi M,Wang H*, Ying Z* (2020). Somatic and germline mutations of the tumor suppressor gene PARK2 impair PINK1/Parkin-mediated mitophagy in lung cancer cells.Acta Pharmacol Sin. 41(1):93-100.
3. Wang H1, Wang N1, Xu D1, Ma Q, Chen Y, Xu S, Xia Q, Zhang Y, Prehn JHM,Wang G,Ying Z*(2020). Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis.Autophagy. 16(9):1683-1696.
4. Wang N1, Ma Q1, Peng P1, Yu Y, Xu S, Wang G,Ying Z*,Wang H* (2020).Autophagy and ubiquitin-proteasome system coordinate to regulate the protein quality control of neurodegenerative disease-associated DCTN1.Neurotox Res. 37(1):48-57.
5. Chen Y1, Xu S1, Wang N, Ma Q, Peng P, Yu Y, Ying Z*,Wang H*(2019).Dynasore suppresses mTORC1 activity and induces autophagy to regulate the clearance of protein aggregates in neurodegenerative diseases.Neurotox Res.36(1):108-116.