Chemical synthesis and functional Studies of complex glycoproteins

Title: Chemical synthesis and functional Studies of complex glycoproteins

Time: 10:00-11:00 on April 1, 2023

Speaker: Researcher Ping Wang

Host: Professor Feng Liu

Tencent Conference: 193-736-124

About the Speaker

ProfessorPing Wang received his Ph.D. from the Shanghai Institute of Organic Chemistry in 2005. After postdoctoral study with Prof. Peter H. Seeberger at Sanford-Burnham Medical Research Institute (2005–2008), he joined the research group of Samuel J. Danishefsky at Memorial Sloan-Kettering Cancer Center (2008-2013). He started his independent research at the Chemistry Department of Shanghai Jiao Tong University in 2016.

In recent years, he published more than 40 research articles inScience,J. Am. Chem. Soc., Angew. Chem. Int. Ed.,Nat. Commun.Three Chinese Invention Patents have been approved. He hosted grants includingNational Science Fund for Distinguished Young Scholars andNational Thousand Talents Program.

Ping Wang has focused on the theme of efficient preparation and functional research of homogeneously glycosylated proteins. He combined late-stage modification of peptides and chemical synthesis to explore protein functions. He developed the general strategy of preparing sulfur/seleno amino acids by photoredox mediated asymmetric Giese reaction, and a new method of orthogonal protection of protein cysteine was developed, which solved the bottleneck of native chemical ligation, which is limited to N-terminal Cys. He further combined chemical synthesis and expression technology, large-scale synthesis of important glycoproteins (such as erythropoietin, COVID-19 spike protein binding domain) were realized, and the effects of glycation on antibody recognition and immune regulation were revealed.