王洪枫

发布者：金雪明发布时间：2022-07-08浏览次数：9567



王洪枫教授

wanghongfeng@suda.edu.cn

研究方向

1.神经退行性疾病的发病分子机制

2.泛素相关蛋白在蛋白质和细胞器质量控制中的作用

学习经历

2004-2009中国科学技术大学神经生物学博士

2000-2004中国科学技术大学生物科学学士

科研经历

2020-至今教授www.优德88.cpm 药学院

2013-2020副教授www.优德88.cpm 药学院

2011-2013博士后www.优德88.cpm 药学院/耶鲁大学医学院

2009-2011 博士后中国科学技术大学生命科学学院

代表性论文

1. Wang M1,Wang H1, Tao Z, Xia Q, Hao Z, Prehn JHM, Zhen X, Wang G*, Ying Z* (2020).C9orf72 associates with inactive RRAG GTPases and regulates MTORC1-mediated autophagosomal and lysosomal biogenesis.Aging Cell. 19(4):e13126.

2. Zhang Z1, Wang N1, Ma Q, Chen Y, Yao L, Zhang L, Li Q, Shi M,Wang H*, Ying Z* (2020). Somatic and germline mutations of the tumor suppressor gene PARK2 impair PINK1/Parkin-mediated mitophagy in lung cancer cells.Acta Pharmacol Sin. 41(1):93-100.

3. Wang H1, Wang N1, Xu D1, Ma Q, Chen Y, Xu S, Xia Q, Zhang Y, Prehn JHM,Wang G,Ying Z*(2020). Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis.Autophagy. 16(9):1683-1696.

4. Wang N1, Ma Q1, Peng P1, Yu Y, Xu S, Wang G,Ying Z*,Wang H* (2020).Autophagy and ubiquitin-proteasome system coordinate to regulate the protein quality control of neurodegenerative disease-associated DCTN1.Neurotox Res. 37(1):48-57.

5. Chen Y1, Xu S1, Wang N, Ma Q, Peng P, Yu Y, Ying Z*,Wang H*(2019).Dynasore suppresses mTORC1 activity and induces autophagy to regulate the clearance of protein aggregates in neurodegenerative diseases.Neurotox Res.36(1):108-116.

6. Mao J, Xia Q, Liu C, Ying Z,Wang H* and Wang G* (2017)A critical role of Hrd 1 in the regulation of optineurin degradation and aggresome formation.Hum Mol Genet.26(10):1877-1889.

7. Zhang Z1,Wang H1, Ding Q1, Xing Y1, Xu D1, Xu Z, Zhou T, Qian B, Ji C, Pan X, Zhong A, Ying Z*, Zhou C*, Shi M* (2017).The tumor suppressor p53 regulates autophagosomal and lysosomal biogenesis in lung cancer cells by targeting transcription factor EB.Biomed Pharmacother. 89：1055-1060

8. Ying Z, Xia Q, Hao Z, Xu D, Wang M,Wang H* and Wang G* (2016)TARDBP/TDP-43 regulates autophagy in both MTORC1-dependent and MTORC1-independent manners.Autophagy12(4):707–8.

9. Zhou L1,Wang H1, Ren H, Hu Q, Ying Z* and Wang G* (2015).Bcl-2 Decreases the Affinity of SQSTM1/p62 to Poly-Ubiquitin Chains and Suppresses the Aggregation of Misfolded Protein in Neurodegenerative Disease.Mol Neurobiol.52(3):1180-9.

10. Ying Z1,Wang H1,Wang G*(2013).The ubiquitin proteasome system as a potential target for the treatment ofneurodegenerative diseases.Curr Pharm Des.19(18):3305-14.

11. Wang H1, Ying Z1, Wang G*(2012).Ataxin-3 Regulates Aggresome Formation of Copper-Zinc Superoxide Dismutase (SOD1) by Editing K63-linked Polyubiquitin Chains.J Biol Chem.287(34):28576-85.

12. Ying Z,Wang H*, Fan H, Wang G*(2011). The ER-associated degradation system regulates aggregation and degradation of mutant neuroserpin.J Biol Chem.286(23):20835-44.

13. Wang H，Jia N，Fei E，Wang Z，Liu C，Zhang T，Fan J，Wu M，Chen L，Nukina N，Zhou J，Wang G (2007). p45, an ATPase subunit of the 19S proteasome, targets the polyglutamine disease protein ataxin-3 to the proteasome，J Neurochem. 101(6)：1651~1661

科研项目

1.国家自然科学基金面上项目，82071274，氨基酸诱导的mTORC1信号通路参与SCA3/MJD发病的作用机制，2021/01-2024/12，在研，主持

2.国家自然科学基金面上项目，31771117，去泛素化酶ataxin-3对线粒体自噬的调节作用，2018/01-2021/12，在研，主持

3.国家自然科学基金面上项目，31371072，去泛素化酶Ataxin-3介导线粒体损伤以及参与神经退行性疾病发病的机制，2014/01-2017/12，已结题，主持

4.国家自然科学基金青年科学基金，31000473，Ataxin-3介导的K63位去泛素化促进神经退行性疾病相关蛋白的聚集，2011/01-2013/12，已结题，主持。

5.中国博士后科学基金面上项目，20090460734，内质网关联降解通路对不同磷酸化形式ataxin-3的降解影响及其机制，2009/8-2011/6,已结题，主持。

6.苏州市高等院校、科研院所紧缺高层次人才引进资助，2014年入选