姓　　名：刘峰

职称职务：教授

联系电话：0512-65882569

电子邮箱：fliu2@suda.edu.cn

办公地址：苏州市工业园区仁爱路199号药学院云轩楼1434

个人简介：

一、学习工作经历

2012.9— 至今：副教授，教授，www.优德88.cpm 医学部药学院

2009.5— 2012.8：博士后研究助理，北卡罗来纳大学教堂山分校药学院

2009.1—2009.5；助理研究员，中科院上海有机所

2003.9— 2009.1：研究生，中科院上海有机所

1999.9— 2003.7：本科， 厦门大学化学系

二、研究方向

（1）表观遗传蛋白小分子调控剂的设计与合成

（2）神经疾病和癌症的“靶向治疗”药物研发

（3）有机合成新方法在药物研发中的应用

三、主要学术科研成果

先后主持国家自然科学基金、江苏省自然科学基金等项目十余项，曾参与国家自然科学基金重点项目、美国NCI、NIH、美国国防部等项目研究；在Nat. Chem. Biol.、Chem、J. Med. Chem.、Org. Lett.和Chem. Commun.等学术期刊上发表SCI论文80余篇。

（论文引用见：http://scholar.google.com/citations?user=h_j1fQYAAAAJ&hl=en）

2025

84) Tan, G.-Q.; Zhou, Q.-L.; Qin, H.-T.; Liu, F.* Access to 5-to 14-Membered N‑Heterocycles by Alkylamination of 1,3-Dienes via Palladium Catalysis. Org. Lett.2025, DOI: 10.1021/acs.orglett.5c00508.

2024

83) Ling, T.-P.; Qin, H.-T.;* Liu, F.* Recent Advances in Enantioselective Radical Reactions of C(sp3)–H Bond. Chin. J. Org. Chem.2024, DOI:10.6023/cjoc202406042.

82) Gaolei Zuo, Haojie Xu, Yaobin Zhang, Zhi Liu, Jinyue Tu, Donghui Gou, Peng Fu, Haifeng Huang, Jianhua Ren, Yuanyuan Hu, Feng Liu*, Jie Jack Li*, Guiping Zhang*, Development of a Practical Telescoped Process to Prepare (P)-7-(2-Amino-6-fluorophenyl)-4-hydroxy-6-(trifluoromethyl)pyrido[3,4-d]pyrimidin-8(7H)-one: a Key Intermediate of KRASG12C Inhibitor GH35. Org. Process Res. Dev.2024, 28(10), 3871–3882. DOI: 10.1021/acs.oprd.4c00279.

81) Ke-Dong Xu, Xing-Yu Gong, Meng Li, Lin Yi, Hai-Tao Qin, Feng Liu*，N-Directed, Radical Relay Enantioconvergent Sulfinylation of Distal C(sp3)-H Bonds via Cobalt Catalysis. Org. Lett.2024, 26, 8999-9004. DOI: 10.1021/acs.orglett.4c03094.

80) Chen, Y.-T.; Jiang, H.-Q.; Sun, Z.-B.; Liu, F.* andSu, M.*Hydantoin derivative dimers as broad-spectrum antimicrobial agents against ESKAPE pathogens with enhanced killing rate and stability. RSC Med. Chem.2024,15, 2340-2350.DOI: 10.1039/d4md00374h.

79) Tan, G.-Q.; Xu, K.-D.; Qin, H.-T.; Liu, F;*Nitrogen-directed unactivated γ-C(sp3)–H functionalization of amides toward 7-membered lactones via photoredox catalysis. Org. Chem. Front. 2024,11, 3724 – 3728. DOI: 10.1039/D4QO00564C.

78) Yang, J.-W.; Li, M.; Tan, G.-Q.; Liu, F;* Qin, H.-T.*N-Directed defluorinative γ-C(sp3)−H allylation of sulfamate esters for synthesis of gem-difluoroalkenes via photoredox catalysis. Eur.J. Org. Chem.2024,27, e202400011. DOI: 10.1002/ejoc.202400011.

2023

77) Chen, Y.-T.; Ye, Z.-F.; Zhen, W.-T.; Zhang, L.; Min, X.-Y.; Wang, Y.-P. *; Liu, F.* andSu, M.* Design and Synthesis of Broad-spectrum Antimicrobial Amphiphilic Peptidomimetics to Combat Drug-resistance, Bioorg. Chem.2023, 140:106766. DOI: 10.1016/j.bioorg.2023.106766

76) Xu, K.-D.; Yang, J. W.; Qin, H.-T.; Liu, F.* Amidyl Radical Directed γ-C(sp3)–H Functionalization with Silyl Enol Ethers via Photoredox Catalysis, Eur.J. Org. Chem.2023, e202300543.DOI: 10.1002/ejoc.202300543

75) Wu, H.; He, S.-H.; Qin, H.-T.; Liu, F.* “Photoredox-catalyzed, oxygen-directed unactivated γ-C(sp3)–H functionalization toward oxepanes” Org. Chem. Front. 2023, 10, 3870-3874.DOI: 10.1039/D3QO00689A

74) He, S.-H.; Chen, G.-L.; Gong, X.-Y.; Ao, G.-Z.; Liu, F.* “Catalytic Decarboxylative Radical Sulfinylation” J. Org. Chem.2023, 88(11), 6671-6681.DOI: 10.1021/acs.joc.2c03051

73) Ma Su, Zhang Li, Duanyang Yan, Xingyue Ji* and Feng Liu* “Chemical Strategies Toward Prodrugs And Fluorescent Probes For Gasotransmitters” Mini-Reviews In Medicinal Chemistry, 2024, 24(3), 300-329. DOI: 10.2174/1389557523666230427152234.

2022

72) Yang, J.-W.; Tan, G.-Q.; Liang, K.-C.; Xu, K.-D.; Su, M.; Liu, F.* “Copper-Catalyzed, N-Directed Distal C(sp3)-H Functionalization toward Azepanes” Org. Lett.2022,24(42), 7796-7800. DOI: 10.1021/acs.orglett.2c03135.

71) Tang, W.; Yan, D.-Y.; Liang, K.-C.; Su, M.*;Liu, F.* “Radical-mediated alkene carboamination/dearomatization of arylsulfonyl-o-allylanilines via photoredox catalysis”Org. Chem. Front.2022,9(23), 6535-6539. DOI: 10.1039/D2QO01221A.

70) Fang, J.; Min, Q.-Q.; Qin, H.-T.*Liu, F.*“Intermolecular Acylation with Acylphosphonates as Alkyl Radical Receptor Under Metal-Free Conditions”Chin. J. Org. Chem.2022，42(12), 4332-4339. DOI: 10.6023/cjoc202207044. (三区，方晶, 闵庆强, 秦海涛, 刘峰，无金属条件下以酰基膦酸酯为烷基自由基受体的分子间酰化反应，有机化学)

69)Tu, J.-L.; Tang, W.; He, S.-H.; Su, M.;Liu, F.*“Acceptorless dehydrogenative amination of alkenes for the synthesis of N-heterocycles”Sci. China. Chem.2022, 65(7), 1330-1337.Doi: 10.1007/s11426-022-1241-x.

2021

68) Chen, G.-L.; He, S.-H.; Cheng, L.*; Liu, F.* “Copper-Catalyzed N-Directed Distal C(sp3)-H Sulfonylation and Thiolation with Sulfinate Salts” Org. Lett.2021, 23(21), 8338-8342.DOI: 10.1021/acs.orglett.1c03075

67) Tu, J.-L.; Yang, J.-W.; Xu, W.; Su, M.;Liu, F.* “Amidyl radical-mediated aminodifluoroallylation of alkenes via photoredox catalysis”Org. Chem. Front.2021, 8(22), 6405–6410. DOI: 10.1039/D1QO01208H

66) Tu, J.-L.; Tang, W.;Liu, F.*“Photoredox-Neutral Alkene Aminoarylation for the Synthesis of 1,4,5,6-Tetrahydropyridazines”Org. Chem. Front.2021,8(14), 3712 – 3717. DOI: 10.1039/D1QO00325A

65) Zhu, Z.-F.; Chen, G.-L.;Liu, F.*“Ruthenium-catalysed meta-selective C_Ar–H bond alkylation via deaminative strategy”Chem. Commun.2021,57(27), 3411-3414. DOI: 10.1039/D1CC00039J.

64) Su, M.; Gong, X.-Y.;Liu, F.*“An update on the emerging approaches for histone deacetylase (HDAC) inhibitor drug discovery and future perspectives”Expert Opinion on Drug Discovery2021,16(7), 745-761. DOI: 10.1080/17460441.2021.1877656.

63) Tu, J.-L.; Tang, W.; Xu, W.;Liu, F.*“Iminyl Radical-Promoted C-C Bond Cleavage/Heck-Like Coupling via Dual Cobaloxime and Photoredox Catalysis”The Journal of Organic Chemistry2021,86(3), 2929-2940. DOI: 10.1021/acs.joc.0c02834

62) Min, Q.-Q.; Yang, J.-W.; Pang, M.-J.; Ao, G.-Z.*;Liu, F.*“Copper-catalyzed, N-directed remote C(sp³)-H azidation and thiocyanation”Org. Chem. Front.2021,8(2), 249-253. DOI: 10.1039/D0QO01012J.

61) Su, M. Wang, W.;Liu, F.*; Li H.* “Recent progress on the discovery of NLRP3 inhibitors and their therapeutic potential”Current Medicinal Chemistry2021,28(3), 569-582. DOI:10.2174/0929867327666200123093544.

2020

60)Liu, J.-L.;Tu, J.-L.;Liu, F.* “Visible-Light-Promoted Intramolecularα-Allylation of Aldehydes in the Absence of Sacrificial Hydrogen Acceptors”Org. Lett.2020,22, 7369-7372. DOI: 10.1021/acs.orglett.0c02742

59) Qiu, Y. Huang, L.; Fu, J.; Han, C.; Fang, J.; Liao, P.; Chen, Z.; Mo, Y.; Sun, P.; Liao, D.; Yang, L.; Wang, J.; Zhang, Q.; Liu, J.;Liu, F.; Liu, T.; Huang, W.; Yang, H.; Jiang, R. “TREK Channel Family Activator with a Well-Defined Structure-Activation Relationship for Pain and Neurogenic Inflammation”Journal of Medicinal Chemistry2020,63, 3665-3677.DOI: 10.1021/acs.jmedchem.9b02163.

58) Min, Q.-Q.; Yang, J.-W.; Pang, M.-J.; Ao, G.-Z.*;Liu, F.*“Copper-Catalyzed Remote C(sp³)-H Amination of Carboxamides”Org. Lett.2020,22, 2828-2832. DOI: 10.1021/acs.orglett.0c00829.

57) He, J.; Chen, G.; Zhang, B.; Li, Y.; Chen, J.-R.; Xiao, W.-J.;Liu, F.*; Li, C.* “Catalytic Decarboxylative Radical Sulfonylation”Chem2020,6, 1149-1159. DOI: 10.1016/j.chempr.2020.02.003.

56) Tu, J.-L.;Liu, J.-L.;Tang, W.; Su, M.;Liu, F.*“Radical Aza-Cyclization ofa-Imino-oxy Acids for Synthesis of Alkene-Containing N-Heterocycles via Dual Cobaloxime and Photoredox catalysis”Org. Lett.2020,22, 1222-1226. DOI:10.1021/acs.orglett.0c00224.

55) Zhang, M. M.; Li, S.-H.; Tu, J.-L.; Min, Q.-Q.;Liu, F.*“Metal-free iminyl radical-mediated C-C single bond cleavage/functionalization of redox-active oxime esters”Org. Chem. Front.2020,7, 622-627. DOI: 10.1039/c9qo01446b

2019

54) Zhao, Y.; Li, S.-H.; Zhang, M.-M.;Liu, F.*“Synthesis of β,γ-Unsaturated Esters and γ-Ketone Esters with Amino Acid Ester-Derived Katritzky Salts”Acta Chimica Sinica(化学学报)2019,77(9), 916-921. DOI: 10.6023/A19040121

53) Zhu, Z.-F.; Tu, J.-L.;Liu, F.*“Ni-Catalyzed Deaminative Hydroalkylation of Internal Alkynes”Chem. Commun.2019,55, 11478 – 11481. DOI: 10.1039/C9CC05385A.

52) Shen, W.-G.; Wu, Q.-Y.; Gong, X.-Y.; Ao, G.-Z.;Liu, F.*“A facile method for hydroxytrifluoromethylation of alkenes with Langlois reagent and DMSO”Green Chem.2019,21, 2983 – 2987. DOI: 10.1039/C9GC00886A.

51) Christopher J. MacNevin, Takashi Watanabe, Matthew Weitzman, Akash Gulyani, Sheryl Fuehrer, Nicholas K. Pinkin, Xu Tian,Feng Liu, Jian Jin, and Klaus M. Hahn, “Membrane-Permeant, Environment-Sensitive Dyes Generate Biosensors within Living Cells”J. Am. Chem. Soc.2019, 10.1021/jacs.8b09841.

50) Li, B.; Mao, Q.; Zhou, J.;Liu, F.; Ye, N.* “HFIP-promoted Michael reactions: direct para-selective C–H activation of anilines with maleimides”Org. Biomol. Chem.2019,17, 2242-2246.

49) Min, Q.-Q.; Li, N.; Chen, G.-L.;Liu, F.*“Copper-catalysed C(sp3)–N coupling initiated by selective C–C bond cleavage of cyclobutanone oxime esters”Org. Chem. Front.2019,6, 1200-1204. DOI: 10.1039/C9QO00235A.

48) Zhu, Z.-F.; Zhang, M.-M.;Liu, F.*“Radical alkylation of isocyanides with amino acid-/peptide-derived Katritzky salts via photoredox catalysis”Org. Biomol. Chem.2019,17, 1531-1534.DOI: 10.1039/C8OB02786B.

47)Liu, J.-L.; Zhu, Z.-F.;Liu, F.*“Cyanofluorination of vinyl ethers enabled by electron donor-acceptor complexes”Org. Chem. Front.2019,6, 241-244.DOI:10.1039/C8QO01143E.

2018

46) Zhou Z.; Li, H.-Q.*;Liu, F.*“DNA Methyltransferase Inhibitors and Their Therapeutic Potential”Current Topics in Medicinal Chemistry2018, 18(28), 2448-2457.DOI:10.2174/1568026619666181120150122.

45) Zhang, M.-M.;Liu, F.*“Visible-light-mediated allylation of alkyl radicals with allylic sulfones via deaminative strategy”Org. Chem. Front.2018, 5, 3443-3446.DOI: 10.1039/C8QO01046C.

44) Pan, P.; Chen, J.; Li, X.; Li, M.; Y, H.; Zhao, J. J.; Ni, J.; Wang, X.; Sun, H.; Tian, S.; Zhu, F.;Liu, F.; Huang, Y.; Hou, T. “Structure-Based Drug Design and Identification of H2O-Soluble and Low Toxic Hexacyclic Camptothecin Derivatives with Improved Efficacy in Cancer and Lethal Inflammation Models in Vivo”Journal of Medicinal Chemistry2018,61, 8613-8624.DOI: 10.1021/acs.jmedchem.8b00498.

43) Xu, X.; Min, Q.-Q.; Li, N.;Liu, F.*“Visible light-promoted umpolung coupling of aryl tri-/difluoroethanones with 2-alkenylpyridines”Chem. Commun.2018,54, 11017-11020. DOI: 10.1039/C8CC06748A

42) Wu, Q.-Y.;Min, Q.-Q.; Ao, G.-Z.*;Liu, F.* “Radical alkylation of para-quinone methides with 4-substituted Hantzsch esters/nitriles via organic photoredox catalysis”Org. Biomol. Chem.2018,16, 6391-6394. DOI:10.1039/C8OB01641K.

41)Liu, J.-L.;Wu, S.-W.;Wu, Q.-Y.;Liu, F.*Diverse Transformation of Vinyl Azides with 2,2,6,6-Tetramethyl-N-oxopiperidinium.J. Org. Chem.2018,83, 8183-8192. DOI: 10.1021/acs.joc.8b00954.

40) Wu, Q.-Y.;Ao, G.-Z.*;Liu, F.*Redox-neutral tri-/difluoromethylation ofpara-quinone methides with sodium sulfinates.Org. Chem. Front.2018,5, 2061-2064. DOI: 10.1039/C8QO00428E.

39) Kaniskan, H. Ü.; Eram, M. S.; Zhao, K.; Szewczyk, M. M.; Yang, X.; Schmidt, K.; Luo, X.; Xiao, S.; Dai, M.; He, F.; Zang, I.; Lin, Y.; Li, F.; Dobrovetsky, E.; Smil, D.; Min, S.-J.; Lin-Jones, J.; Schapira, M.; Atadja, P.; Li, E.; Barsyte-Lovejoy, D.; Arrowsmith, C. H.; Brown, P. J.;Liu, F.*; Yu, Z.*; Vedadi, M.*; Jin, J.* Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3).Journal of Medicinal Chemistry2018,61, 1204-1217. DOI: 10.1021/acs.jmedchem.7b01674. PMID:29244490

38)Babault, N.; Allali-Hassani, A.; Li, F.; Fan, J.; Yue, A.; Ju, K.;Liu, F.*; Vedadi, M.*; Liu, J.*; Jin, J.* “Discovery of Bisubstrate Inhibitors of NicotinamideN-Methyltransferase (NNMT)”Journal of Medicinal Chemistry2018,61, 1541-1551.DOI: 10.1021/acs.jmedchem.7b01422.

37)Liu, J.-L.; Zhu, Z.-F.;Liu, F.*“Oxycyanation of Vinyl Ethers with 2,2,6,6-Tetramethyl-N-oxopiperidinium Enabled by Electron Donor-Acceptor Complex”Org. Lett.2018,20,720-723.

36）Zhao, Y.;Liu, F.*“Recent advance in radical fluoroalkylation with sulfinate salts”Tetrahedron Lett.2018,59, 180-187. DOI: 10.1016/j.tetlet.2017.12.022

2017

35)Wu, S.-W.; Liu, J.-L.;Liu, F.*“cis-Specific cyanofluorination of vinyl azides enabled by electron-donor-acceptor complexes: synthesis ofa-azido-ß-fluoronitriles”Chem. Commun.2017,53, 12321-12324. DOI: 10.1039/C7CC07165E.

34) Xu, X.;Liu, F.* “Transition-metal-free radical tri-/difluoromethylation ofN,N-dialkylhydrazones with sodium sulfinates”Org. Chem. Front.2017,4, 2306-2310. DOI: 10.1039/C7QO00635G

33) Fang, J.;Shen, W.-G.; Ao, G.-Z.*;Liu, F.*“Transition-metal-free radical fluoroalkylation of isocyanides for the synthesis of tri-/di-/monofluoromethylated phenanthridines”Org. Chem. Front.2017,4, 2049-2053. DOI: 10.1039/C7QO00473G

32) Fang, J.; Wang, Z.-K.;Wu, S.-W.; Shen, W.-G.; Ao, G.-Z.;Liu, F.* “Photoredox-catalysed chloro-, bromo- and trifluoromethylthiotrifluoromethylation of unactivated alkenes with sodium triflinate”Chem. Commun.2017,53, 7638-7641.DOI:10.1039/C7CC01903C.

31) Qin, H.-T.; Xu, X.;Liu, F.*“Aerobic Oxidation of Alkynes into 1,2-Diketones via Organic Photoredox Catalysis”ChemCatChem2017,9, 1409-1412. DOI: 10.1002/cctc.201700061

30) Qin, H.-T.; Wu, S.-W.; Liu, J.-L.;Liu, F.*“Photoredox-Catalysed Redox-Neutral Trifluoromethylation of Vinyl Azides for the Synthesis of a–Trifluoromethylated Ketones”Chem. Commun.2017,53, 1696-1699.

29) Qin, H.-T.; Li, H.-Q.;*Liu, F.*“Selective histone deacetylase small molecule inhibitors: recent progress and perspectives”Expert Opin. Ther. Pat.2017,27, 621-636. DOI: 10.1080/13543776.2017.1276565

2016

28) Wu, S.-W.;Liu, F.*“Synthesis ofα-Fluoroketones from Vinyl Azides and Mechanism Interrogation”Org. Lett.2016,18, 3642-3645.

27) Li, Z.-R.; Bao, X.-X.; Sun, J.; Shen, J.; Wu, D.-Q.; Liu, Y.-K.; Deng, Q.-H.*;Liu, F.*“Iron-catalyzed trifluoromethylation of vinylcyclopropanes: facile synthesis of CF3-containing dihydronaphthalene derivatives”Org. Chem. Front.2016,3, 934-938.

26) Wu, S.-W.; Liu, J.-Li.;Liu, F.*“Metal-Free Microwave-Assisted Decarboxylative Elimination for the Synthesis of Olefins”Org. Lett.2016,18, 1-3.

2015

25) Simon, J. M.; Parker, J. S.;Liu, F.; Rothbart, S. B.; Ait-Si-Ali, S.; Strahl, B. D.; Jin, J.; Davis, I. J.; Mosley, A. L.; Pattenden, S. G.“A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin”J. Biol. Chem.2015, 290(43):26088-26102. DOI: 10.1074/jbc.M115.654459.PMID: 26338712

24) Zhang, Y.; Xu, L.; Zhang, Z.; Zheng, L.; Li, D.; Li, Y.;Liu, F.; Yu, K.; Hou, T.; Zhen, X. “Structure-Activity Relationships and Anti-inflammatory Activities of N-Carbamothioylformamide Analogues as MIF Tautomerase Inhibitors”J. Chem. Inf. Model.2015, 55, 1994-2004.DOI: 10.1021/acs.jcim.5b00445

23) Shi, D.; Qin, H.;Zhu, C;* Liu, F.*“Selectfluor–Bu₄NI-Mediated C(sp³)–H Oxidation in Aqueous Media: Synthesis ofΔ²-Isoxazolines from Oximes”Eur.J. Org. Chem.2015,5084-5088. DOI: 10.1002/ejoc.201500780

22) Wang, L.; Xie, L.; Ramachandran, S.; Lee, Y.; Yan, Z.; Zhou, L.; Krajewski, K.;Liu, F.; Zhu, C.; Chen, David J.; Strahl, Brian D.; Jin, J.; Dokholyan, Nikolay V.; Chen, X.“Non-canonical Bromodomain within DNA-PKcs Promotes DNA Damage Response and Radioresistance through Recognizing an IR-Induced Acetyl-Lysine on H2AX”Chem. Biol.2015,22, 7, 849-861. DOI: 10.1016/j.chembiol.2015.05.014.

21) Zhang, Z.;Liu, F.*“CuX₂-mediated oxybromination/aminochlorination of unsaturated amides: synthesis of iminolactones and lactams”Org. Biomol. Chem.2015,13, 6690-6693.DOI: 10.1039/c5ob00520e

20)Dong, K.; Qin, H.;Liu, F.*; Zhu, C.*“Oxime-Mediated Oxychlorination and Oxybromination of Unactivated Olefins”Eur.J. Org. Chem.2015,1419-1422. DOI: 10.1002/ejoc.201403538

2014

19)Liu, C.; Yu, Y.;Liu, F.; Wei, X.; Wrobel, J. A.; Gunawardena, H. P.; Zhou, L.; Jin, J.; Chen, X. “A chromatin activity-based chemoproteomic approach reveals a transcriptional repressome for gene-specific silencing”Nat. Commun.2014, 5:5733. DOI: 10.1038/ncomms6733.

18) Dong, K.; Qin, H.; Bao, X.;Liu, F.*;Zhu, C.* “Oxime-mediated facile access to 5-methylisoxazoles and applications in the synthesis of valdecoxib and oxacillin”Org. Lett.2014,16, 5266-5268.

17)Sundriyal, S.;Malmquist, N. A.;Caron, J.;Blundell, S.;Liu, F.;Chen, X.;Srimongkolpithak, N.;Jin, J.;Charman, S. A.;Scherf, A.;Fuchter, M. J. “Development of Diaminoquinazoline Histone Lysine Methyltransferase Inhibitors as Potent Blood-Stage Antimalarial Compounds”ChemMedChem,2014,9, 2360-2373.

16)Lehnertz, B.;Pabst, C.;Su, L.;Miller, M.;Liu, F.;Yi, L.;Zhang, R.,Krosl, J.,Yung, E.,Kirschner, J.,Rosten, P.,Underhill, T. M.,Jin, J.,Hébert, J.,Sauvageau, G.,Humphries, R. K.,Rossi, F. M. “The methyltransferase G9a regulates HoxA9-dependent transcription in AML”Genes Dev.2014,28,317-327.

15) Konze, K. D.; Pattenden, S. G.;Liu, F.; Barsyte-Lovejoy, D.; Li, F.; Simon, J. M.; Davis, I. J.; Vedadi, M.; Jin, J.“A chemical tool forin vitroandin vivoprecipitation of lysine methyltransferase G9a”ChemMedChem,2014,9, 549-553.

14)Liu, F.*; Li. C. “Total synthesis of (S)-14-azacamptothecin”,Org. Biomol. Chem.2014,12, 637-642.

2013

13)Liu, F.; Barsyte-Lovejoy, D.; Li, F.; Xiong, Y.; Korboukh, V.; Huang, X. P.; Allali-Hassani, A.; Janzen, W. P.; Roth, B. L.; Frye, S. V.; Arrowsmith, C. H.; Brown, P. J.; Vedadi, M.; Jin, J. “Discovery of an in vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP”J. Med. Chem.2013,56, 8931-8942.

12) Konze, K. D.; Ma, A.; Li, F.; Barsyte-Lovejoy, D.; Parton, T.; MacNevin, C. J.;Liu, F.; Gao, C.; Huang, X. P.; Kuznetsova, E.; Rougie, M.; Jiang, A.; Pattenden, S. G.; Norris, J. L.; James, L. I.; Roth, B. L.; Brown, P. J.; Frye, S. V.; Arrowsmith, C. H.; Hahn, K. M.; Wang, G. G.; Vedadi, M.; Jin, J. “An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1”,ACS Chemical Biology,2013,8, 1324-1334.

11）Liu, F.;Li, F.; Ma, A.; Dobrovetsky, E.; Dong, A.; Gao, C.; Korboukh, I.; Liu, J.; Smil, D.; Brown, P. J.; Frye, S. V.; Arrowsmith, C. H.; Schapira, M.; Vedadi, M.; Jin, J. “Exploiting an Allosteric Binding Site of PRMT3 Yields Potent and Selective Inhibitors”J. Med. Chem.2013,56, 2110-2124.

Before 2013

10）Siarheyeva, A.; Senisterra, G.; Allali-Hassani, A.; Dong, A.; Dobrovetsky, E.; Wasney, Gregory A.; Chau, I.; Marcellus, R.; Hajian, T.;Liu, F.; Korboukh, I.; Smil, D.; Bolshan, Y.; Min, J.; Wu, H.; Zeng, H.; Loppnau, P.; Poda, G.; Griffin, C.; Aman, A.; Brown, Peter J.; Jin, J.; Al-awar, R.; Arrowsmith, Cheryl H.; Schapira, M.; Vedadi, M. "An Allosteric Inhibitor of Protein Arginine Methyltransferase 3"Structure2012,20, 1425-1435.

9）Liu, F.; Barsyte-Lovejoy, D.; Allali-Hassani, A.; He, Y.; Herold, J. M.; Chen, X.; Yates, C. M.; Frye, S. V.; Brown, P. J.; Huang, J.; Arrowsmith, C. H.; Jin, J. “Optimization of Cellular Activity of G9a Inhibitors 7-Aminoalkoxy-quinazolines”.J. Med. Chem.2011,54, 6139-6150.

8）Yost, J. M.; Korboukh, I.;Liu, F.; Gao, C.; Jin, J. “Targets in Epigenetics: Inhibiting the Methyl Writers of the Histone Code”.Curr.Chem.Genomics2011,5, 72-84. (共同第一作)

7）Vedadi, M#.; Barsyte-Lovejoy, D#.;Liu, F#.; Rival-Gervier, S.; Allali-Hassani, A.; Labrie, V.; Wigle, T. J.; DiMaggio, P. A.; Wasney, G. A.; Siarheyeva, A.; Dong, A.; Tempel, W.; Wang, S.-C.; Chen, X.; Chau, I.; Mangano, T.; Huang, X.-P.; Simpson, C. D.; Pattenden, S. G.; Norris, J. L.; Kireev, D. B.; Tripathy, A.; Edwards, A.; Roth, B. L.; Janzen, W. P.; Garcia, B. A.; Petronis, A.; Ellis, J.; Brown, P. J.; Frye, S. V.; Arrowsmith, C. H.; Jin, J. “A Chemical Probe Selectively Inhibits G9a and GLP Methyltransferase Activity in Cells”.Nature Chem. Biol.2011,7, 566-574. (共同第一作，Highlighted by News and Views:Nature Chemical Biology, 2011, 7, 499-500 and SciBX, 2011, 4(31), doi:10.1038/scibx.2011.890）

6）Liu, F.; Chen, X.; Allali-Hassani, A.; Quinn, A. M.; Wigle, T. J.; Wasney, G. A.; Dong, A.; Senisterra, G.; Chau, I.; Siarheyeva, A.; Norris, J. L.; Kireev, D. B.; Jadhav, A.; Herold, J. M.; Janzen, W. P.; Arrowsmith, C. H.; Frye, S. V.; Brown, P. J.; Simeonov, A.; Vedadi, M.; Jin, J. “Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines”.J. Med. Chem.2010,53, 5844-5857.

5）Liu, F.; Chen, X.; Allali-Hassani, A.; Quinn, A. M.; Wasney, G. A.; Dong, A.; Barsyte, D.; Kozieradzki, I.; Senisterra, G.; Chau, I.; Siarheyeva, A.; Kireev, D. B.; Jadhav, A.; Herold, J. M.; Frye, S. V.; Arrowsmith, C. H.; Brown, P. J.; Simeonov, A.; Vedadi, M.; Jin, J. “Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a”.J. Med. Chem.2009,52, 7950-7953.

4）Ju, Y.;Liu, F.; Li. C. “Palladium-Catalyzed Sequential Cyanation/N-Addition/ N-Arylation in One-Pot: Efficient Synthesis of Luotonin A and Its Derivatives”.Org. Lett.2009,11, 3582-3585.

3）Liu, F.; Li. C. “Intramolecular Formal [4 + 2] Cycloaddition of Nitriles with Amides Triggered by TMSOTf/Et3N: Highly Efficient Construction of Pyrrolo[1,2-a]pyrimidin-4(6H)-ones”.J. Org. Chem.2009,74, 5699-5702.

2）Liu, F.; Liu, K.; Yuan, X.; Li. C. “5-Exo versus 6-Endo Cyclization of Primary Aminyl Radicals: An Experimental and Theoretical Investigation”.J. Org. Chem.2007,72, 10231-10234.

1）Zhan, Z.; Lang, K.;Liu, F.; Hu, L. “Water Effects on SmI₂Reductions: A Novel Method for the Synthesis of Alkyl Thiols by SmI₂-Promoted Reductions of Sodium Alkyl Thiosulfates and Alkyl Thiocyanates”.Syn. Commun.2004,34, 3203.