张谷芳

姓　　名：张谷芳

职称职务：助理教授

电子邮箱：gfzhang@suda.edu.cn

办公地址：云轩楼2306

一、学习工作经历

1、学历背景：

2004.09 - 2008.06：上海中医药大学，理学学士学位

2008.09 - 2011.06：第二军医大学，医学硕士学位

2013.09 - 2018.09:上海交通大学,医学博士学位

2、工作经历：

2011.07-2012.07:上海药明康德新药研发有限公司新药研发平台,研究员

2012.08-2013.08:第二军医大学附属长海医院泌尿外科研究室,研究员助理

2018.10-至今:www.优德88.cpm 医学部药学院,助理研究员

二、研究方向：

(1)新型sigma-1R配体的筛选及功能研究；

(2)研究胶质细胞介导的炎症反应在神经退行性病变中调控机制；

(3)血清淀粉样蛋白A通过不同机制调控炎症反应,调控疾病的病理生理过程。

三、发表文章：

1.Zhang G, Liu J, Wu L, Fan Y, Sun L, Qian F, Chen D, Ye RD. Elevated expression of SAA3 protects colon epithelium against acute injury through TLR2-dependent induction of neutrophil IL-22 expression in a mouse model of colitis. Frontiers in Immunology.2018; 29 (9): 1503-1514.

2. Zhou H, Chen M,Zhang G, Ye RD. Suppression of Lipopolysaccharide-Induced Inflammatory Response by Fragments from Serum Amyloid A. J Immunol. 2017; 199(3): 1105-1112.

3. Fan C, Wu LH,Zhang GF, Xu F, Zhang S, Zhang X, Sun L, Yu Y, Zhang Y, Ye RD. 4'-Hydroxywogonin suppresses lipopolysaccharide-induced inflammatory responses in RAW 264.7 macrophages and acute lung injury mice. Plos One. 2017; 12(8): e0181191.

4. Liang Q, Cheng N,Zhang G, Liang Y, Qian F, Wu D, Ye RD. Identification of P-Rex1 as an anti-inflammatory and anti-fibrogenic target for pulmonary fibrosis. Sci Rep. 2016 13:25785.

5. Liu C, Zhang X, Zhou JX, Wei W, Liu DH, Ke P,Zhang GF, Cai GJ, Su DF. The protective action of ketanserin against lipopolysaccharide-induced shock in mice is mediated by inhibiting inducible NO synthase expression via the MEK/ERK pathway. Free Radic Biol Med. 2013; 65:658-66.

6. Sun L*,Zhang GF*, Zhang X, Liu Q, Liu JG, Su DF, Liu C. Combined administration of anisodamine and neostigmine produces anti-shock effects: involvement of alpha 7 nicotinic acetylcholine receptors. Acta Pharmacologica Sinica. 2012; 33(6):761-6.（共同第一）

7. Liu C*,Zhang GF*, Song SW, Cai GJ, Liu WH, Miao CY, Su DF. Effects of ketanserin on endotoxic shock and baroreflex function in rodents. The Journal of Infectious Diseases.2011; 204:1605-12.（共同第一）