姓名:陆朦辰
职务职称:博士,副教授,硕士生导师
联系邮箱:mclu@suda.edu.cn
联系地址:www.优德88.cpm 独墅湖校区二期药学院云轩楼1233
教育经历:
(1)2012-09至2017-06,中国药科大学,药物化学,博士,导师 尤启冬教授
(2)2008-09至2012-06,中国药科大学,药学,学士
(3)2017-06至2020-06,中国药科大学,博士后
科研与学术工作经历:
(1)2021-06至 今,www.优德88.cpm,药学院药物化学系,副教授
(2)2020-06至2021-05,中国药科大学,药学院药物化学系,副研究员
研究领域:
靶向转录因子调控的小分子创新药物研发
研究方向:
主要研究方向为药物化学及化学生物学,通过运用药物设计学、化学生物学、药物化学等多学科交叉手段,开展靶向泛素E3连接酶和转录因子家族的药物化学生物学研究及创新药物的研发工作。
学术荣誉和社会任职:
www.优德88.cpm 优秀青年学者,姑苏“双创领军人才”,Molecules期刊客座编辑和ECEB Member,《中国药科大学学报》、《中国药物化学杂志》青年编委。
主持基金项目/课题:
1、国自然面上项目(2023.01-2026.12,51万元,在研)
2、国自然青年项目(2019.01-2021.12,21万元,结题)
3、中国博士后特别资助项目(2018.03-2020.06,15万元,结题)
4、中国博士后面上项目(2018.03-2020.06,8万元,结题)
5、姑苏创新创业领军人才项目(2022.07-2025.07,50万元,在研)
6、江苏省高校面上项目(2022.07-2024.07,3万元,结题)
代表性论文和专利:
1. Zhao, Z. Q.; Lu, H. J.; Wang, J. J.; Wu, T. T.; Xu, S. C.; Ge, Y. X.; You, Q. D.; Jiang, Z. Y.;Lu, M. C.Discovery of β-amino acid substituted naphthalene sulfonamide derivatives as potent Kelch-like ECH-associated protein 1−nuclear factor erythroid 2-related factor 2 (Keap1−Nrf2) protein−protein interaction inhibitors for ulcerative colitis management.Eur. J. Med. Chem.2025, 288, 117384.IF =6.0
2. Luo, Y. F.; Yang, Z. Y.; Zhang, Y.; Jiang, S. T.; Zhu, J. Y.; Li, X. Y.; You, Q. D.;Lu, M. C.Patenting perspective on Keap1 inhibitors (2019-2024).Expert Opin. Ther. Pat.2025.IF =5.4
3.M. C. Lu#, J. A. Ji#, Y. F. Lv, J. Zhao, Y. T. Liu, Q. Jiao, T. Liu, Y. Mou, Q. D. You, Z. Y. Jiang, Bivalent inhibitors of the BTB E3 ligase KEAP1 enable instant NRF2 activation to suppress acute inflammatory response.Cell Chem. Biol.2023, 21, S2451-9456.IF =8.6
4.M. C. Lu, X. Zhang, J. Zhao, Q. D. You, Z. Y. Jiang, A hydrogen peroxide responsive prodrug of Keap1-Nrf2 inhibitor for improving oral absorption and selective activation in inflammatory conditions.RedoxBiol. 2020, 34, 101565.IF =11.4
5.M. C. Lu, J. Zhao, Y. T. Liu, T. Liu, M. M. Tao, Q. D. You, Z. Y. Jiang, CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation.Redox Biol.2019, 26, 101266.IF = 11.4
6. Y. H. Jin#,M. C. Lu#, Y. Wang, W. X. Shan, X. Y. Wang, Q. D. You, Z. Y. Jiang, Azo-PROTAC: Novel Light-Controlled Small-Molecule Tool for Protein Knockdown.J. Med. Chem.2020, 63, 4644-4654.IF =7.3
7.M. C. Lu, X. Zhang, F. Wu, S. J. Tan, J. Zhao, Q. D. You, Z. Y. Jiang, Discovery of a Potent Keap1-Nrf2 Protein-Protein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced Hepatotoxicity.J. Med. Chem.2019, 62, 6796-6813.IF = 7.3
8.M. C. Lu, H. L. Shao, T. Liu, Q. D. You, Z. Y. Jiang, Discovery of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 protein-protein interaction inhibitors for inflammatory conditions.Eur. J. Med. Chem.2020, 207, 112734.IF = 6.7