近日，我院彭睿教授课题组与刘庄教授课题组合作的研究成果“Functionalizedgraphene oxide serves as a novel vaccine nano-adjuvant for robust stimulationof cellular immunity”（第一作者：许利耕）入选“2016Hot Articles in Nanoscale”。

文章摘要：

Benefitingfrom their unique physicochemical properties, graphene derivatives haveattracted great attention in biomedicine. In this study, we carefullyengineered graphene oxide (GO) as a vaccine adjuvant for immunotherapy usingurease B (Ure B) as the model antigen. Ure B is a specific antigen forHelicobacter pylori, which is a class Icarcinogen for gastric cancer. Polyethylene glycol (PEG) and various types ofpolyethylenimine (PEI) were used as coating polymers. Compared withsingle-polymer modified GOs (GO�PEG and GO�PEI), certain dual-polymer modifiedGOs (GO�PEG�PEI) can act as a positive modulator to promote the maturation ofdendritic cells (DCs) and enhance their cytokine secretion through theactivation of multiple toll-like receptor (TLR) pathways while showing lowtoxicity. Moreover, this GO�PEG�PEI can serve as an antigen carrier toeffectively shuttle antigens into DCs. These two advantages enable GO�PEG�PEIto serve as a novel vaccine adjuvant. In the subsequentin vivoexperiments, compared with free Ure B and clinically usedaluminum-adjuvant-based vaccine (Alum-Ure B), GO�PEG�PEI�Ure B induces strongercellular immunityviaintradermaladministration, suggesting promising applications in cancer immunotherapy. Ourwork not only presents a novel, highly effective GO-based vaccinenano-adjuvant, but also highlights the critical roles of surface chemistry forthe rational design of nano-adjuvants.

文章链接：http://pubs.rsc.org/en/content/articlelanding/2016/nr/c5nr09208f#!divAbstract

（责任编辑：金晓瑜，联系方式：xyjin@suda.edu.cn）