姓名：Darran O'Connor
邮箱：darranoconnor@rcsi.com
电话：+353 1 402 2596
地址：123 St Stephens Green, Dublin 2，Ireland
个人简介：
Darran教授是研究生学院院长，也是一名分子肿瘤学家。2000年在都柏林圣三一大学获得博士学位后，在纽约哥伦比亚大学和英国格拉斯哥大学从事癌症生物学博士后研究，师从FRSE的Nick La Thangue教授。他还在达纳法伯癌症研究所、哈佛医学院和荷兰癌症研究所担任客座研究员。2009年他被聘为UCD生物分子和生物医学科学学院癌症生物学研究员，2013年被任命为SBBS癌症生物学高级讲师，并于2015年8月加入RCSI。Darran的团队在发现癌症进展的分子决定因素(通过转录组学/功能基因组分析)，使用体外和异种移植模型进行功能分析以及利用组织微阵列进行临床翻译方面拥有丰富的经验。2011年他当选为爱尔兰癌症研究协会理事会成员，获得第九届圣卢克青年研究员奖、欧洲分子生物学组织和人类前沿科学计划奖学金等著名奖项。他在Nature Cell Biology, Nature Reviews Cancer, Nature Communications, Journal of Clinical Oncology, JNCI, Clinical Cancer Research & Cancer Research等国际期刊上发表论文60余篇。
近期论文：
1. Predictive modelling of response to neoadjuvant therapy in HER2+ breast cancer. [Journal Article] Cosgrove N, Eustace A, O'Donovan P, Madden S, Moran B, Crown J, Moulton B, Morris P, Grogan L, Breathnach O, Power C, Allen M, Walshe JM, Hill A, Blümel A, O'Connor D, Das S, Milewska M, Fay J, Kay E, Toomey S, Hennessy B, Furney S Published 27 Sep 2023
2. Implementing subtype-specific pre-clinical models of breast cancer to study pre-treatment aspirin effects. [Journal Article] Miller I, Khan S, Shiels L, Das S, O'Farrell AC, Connor K, Lafferty A, Moran B, Isella C, Loadman P, Conroy E, Cohrs S, Schibli R, Kerbel RS, Gallagher WM, Marangoni E, Bennett K, O'Connor D, Dwyer RM, Byrne A Published 17 Apr 2022
3. Master transcription regulators and transcription factors regulate immune-associated differences between patients of African and European ancestry with colorectal cancer. [Journal Article] Myer PA, Kim H, Blümel A, Finnegan E, Kel A, Thompson TV, Greally JM, Prehn J, O'Connor D, Friedman RA, Floratos A, Das S Published 27 Jan 2022
4. Prognostic value of the 6-gene OncoMasTR test in hormone receptor–positive HER2-negative early-stage breast cancer: comparative analysis with standard clinicopathological factors. [Journal Article] Lynch SM, Russell NM, Barron S, Wang C-JA, Loughman T, Dynoodt P, Fender B, Lopez-Ruiz C, O'Grady A, Sheehan K, Fay J, Amberger-Murphy V, Saha A, Klinger R, Gonzalez CA, Al-Attar N, Rahman A, O'Leary D, Lanigan FT, Bracken AP, Crown J, Kelly CM, O'Connor D, Gallagher WM Published 2 Jun 2021
5. An insight into the driver mutations and molecular mechanisms underlying mucinous adenocarcinoma of the rectum. [Journal Article] Reynolds I, O'Connell E, Fichtner M, Blümel A, Mason SE, Kinross J, McNamara D, Kay E, O'Connor D, Das S, Burke J, Prehn J Published 1 Jun 2021
6. Effects of HER family-targeting tyrosine kinase inhibitors on antibody-dependent cell-mediated cytotoxicity in HER2-expressing breast cancer. [Journal Article] Collins DM, Madden S, Gaynor N, AlSultan D, Gal ML, Eustace AJ, Gately KA, Hughes C, Davies AM, Mahgoub T, Ballot J, Toomey S, O'Connor D, Gallagher WM, Holmes FA, Espina V, Liotta L, Hennessy B, O'Byrne KJ, Hasmann M, Bossenmaier B, O'Donovan N, Crown J Published 1 Feb 2021
7. Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer. [Journal Article] Dowling CM, Hollinshead KER, Grande AD, Pritchard J, Zhang H, Dillon ET, Haley K, Papadopoulos E, Mehta AK, Bleach R, Lindner AU, Mooney B, Duessmann H, O'Connor D, Prehn J, Wynne K, Hemann M, Bradner JE, Kimmelman AC, Guerriero JL, Cagney G, Wong K-K, Letai AG, Chonghaile TN Published 15 Jan 2021
8. A functional genomic screen identifies the deubiquitinase USP11 as a novel transcriptional regulator of ERa in breast cancer. [Journal Article] Dwane L, O'Connor AE, Das S, Moran B, Mulrane L, Pinto-Fernandez A, Ward E, Blümel A, Cavanagh B, Mooney B, Dirac AM, Jirström K, Kessler BM, Chonghaile TN, Bernards R, Gallagher WM, O'Connor D Published 15 Nov 2020
9. Combination of variations in inflammation- and endoplasmic reticulum-associated genes as putative biomarker for bevacizumab response in KRAS wild-type colorectal cancer. [Journal Article] Barat A, Smeets D, Moran B, Zhang W, Cao S, Das S, Klinger R, Betge J, Murphy V, Bacon O, Kay E, Van Grieken NCT, Verheul HMW, Gaiser T, Schulte N, Ebert MP, Fender B, Hennessy B, McNamara D, O'Connor D, Gallagher WM, Cremolini C, Loupakis F, Parikh A, Mancao C, Ylstra B, Lambrechts D, Lenz H-J, Byrne A, Prehn J Published 17 Jun 2020
10. BET Inhibition as a Rational Therapeutic Strategy for Invasive Lobular Breast Cancer. [Journal Article] Walsh L, Haley KE, Moran B, Mooney B, Tarrant F, Madden SF, Grande AD, Fan Y, Das S, Rueda OM, Dowling CM, Varešlija D, Chin SF, Linn S, Young LS, Jirström K, Crown JP, Bernards R, Caldas C, Gallagher WM, O'Connor DP, Chonghaile TN Published 1 Dec 2019
11. FKBPL-based peptide, ALM201, targets angiogenesis and cancer stem cells in ovarian cancer. [Journal Article] Annett S, Moore G, Short A, Marshall A, McCrudden C, Yakkundi A, Das S, McCluggage WG, Nelson L, Harley I, Moustafa N, Kennedy CJ, deFazio A, Brand A, Sharma R, Brennan D, O’Toole S, O’Leary J, Bates M, O’Riain C, O'Connor D, Furlong F, McCarthy H, Kissenpfennig A, McClements L, Robson T Published 27 Nov 2019
12. Correction: BAG3 promotes tumour cell proliferation by regulating EGFR signal transduction pathways in triple negative breast cancer (Oncotarget (2018) 9 (15673-15690) DOI: 10.18632/oncotarget.24590). [Journal Article] Shields S, Conroy E, O'Grady A, McGoldrick A, Connor K, Ward MP, Useckaite Z, Dempsey E, Reilly R, Fan Y, Chubb A, Matallanas DG, Kay E, O'Connor D, McCann A, Gallagher WM, Coppinger J Published 3 May 2019
13. Targeted DNA Methylation Profiling of Human Cardiac Tissue Reveals Novel Epigenetic Traits and Gene Deregulation Across Different Heart Failure Patient Subtypes. [Journal Article] Glezeva N, Moran B, Collier P, Moravec CS, Phelan D, Donnellan E, Russell-Hallinan A, O'Connor D, Gallagher WM, Gallagher J, Mcdonald K, Ledwidge M, Baugh J, Das S, Watson CJ Published 1 Mar 2019