姓名：John Waddington
邮箱：jwaddington@rcsi.com
电话：01 4022129
地址：123 St Stephens Green, Dublin 2, Ireland
个人简介：
在完成神经科学的本科和研究生学习，并在英国医学研究委员会担任科学人员一段时间后，John Waddington 教授加入RCSI，指导在临床前和临床神经科学领域享有国际声誉的多学科研究小组，通过临床研究和实验室模型，了解精神病的发育病理生物学和抗精神病药物的作用。
研究方向：
精神分裂症和双相情感障碍的流行病学、病理生物学和治疗;涉及精神病风险和/或病理生物学相关基因的敲除和转基因模型；抗精神病药物的作用机制；多巴胺受体亚型的功能作用；颅面畸形的三维表面成像和几何形态计量学作为脑畸形发生的指标。
近期论文：
1. Paratonia, Gegenhalten and psychomotor hypertonia Back to the roots. [Journal Article] Foucher JR, Dormegny-Jeanjean LC, Bartsch AJ, Humbert I, de Billy CC, Obrecht A, Mainberger O, Clauss JME, Waddington J, Wolf RC, Hirjak D, Morra C, Ungvari G, Schorr B, Berna F, Shorter E Published 1 Jan 2024
2. From one to many: Hypertonia in schizophrenia spectrum psychosis an integrative review and adversarial collaboration report. [Journal Article] Foucher JR, Hirjak D, Walther S, Dormegny-Jeanjean LC, Humbert I, Mainberger O, de Billy CC, Schorr B, Vercueil L, Rogers J, Ungvari G, Waddington J, Berna F Published 1 Jan 2024
3. Duration of the psychosis prodrome and its relationship to duration of untreated psychosis across all 12 DSM-IV psychotic diagnoses: evidence for a trans-diagnostic process associated with resilience.. [Journal Article] Nkire N, Kinsella A, Russell V, Waddington J Published 20 Dec 2023
4. Regulation of plasma glucose levels by central dopamine D2 receptors is impaired in type 1 but not type 2 diabetic mouse models. [Journal Article] Ikeda H, Mikami R, Yonemochi N, Waddington J Published 5 Oct 2023
5. Hypoxia-inducible factor upregulation by roxadustat attenuates drug reward by altering brain iron homoeostasis. [Journal Article] Yan P, Li N, Ma M, Liu Z, Yang H, Li J, Wang C, Gao S, Li S, Zheng L, Waddington J, Xu L, Zhen X Published 18 Sep 2023
6. Adolescence as a critical period for nandrolone-induced muscular strength in relation to abuse liability, alone and in conjunction with morphine, using accumbal dopamine efflux in freely moving rats. [Journal Article] Kawashima H, Aono Y, Shimba S, Waddington J, Saigusa T Published 13 Jan 2023
7. DUP redux: observations vs. experiments in early intervention (Letter to the Editor in reply to Srihari and Li). [Journal Article] Nkire N, Kingston T, Kinsella A, Russell V, Waddington J Published 15 Dec 2022
8. Gender, age at onset, and duration of being ill as predictors for the long-term course and outcome of schizophrenia: an international multicenter study. [Journal Article] Fountoulakis KN, Dragioti E, Theofilidis AT, Wiklund T, Atmatzidis X, Nimatoudis I, Thys E, Wampers M, Hranov L, Hristova T, Aptalidis D, Milev R, Iftene F, Spaniel F, Knytl P, Furstova P, From T, Karlsson H, Walta M, Salokangas RKR, Azorin JM, Bouniard J, Montant J, Juckel G, Haussleiter IS, Douzenis A, Michopoulos I, Ferentinos P, Smyrnis N, Mantonakis L, Nemes Z, Gonda X, Vajda D, Juhasz A, Shrivastava A, Waddington J, Pompili M, Comparelli A, Corigliano V, Rancans E, Navickas A, Hilbig J, Bukelskis L, Stevovic LI, Vodopic S, Esan O, Oladele O, Osunbote C, Rybakowski JK, Wojciak P, Domowicz K, Figueira ML, Linhares L, Crawford J, Panfil AL, Smirnova D, Izmailova O, Lecic-Tosevski D, Temmingh H, Howells F, Bobes J, Garcia-Portilla MP, García-Alvarez L, Erzin G, Karadağ H, De Sousa A, Bendre A, Hoschl C, Bredicean C, Papava I, Vukovic O, Pejuskovic B, Russell V, Athanasiadis L, Konsta A, Fountoulakis NK, Stein D, Berk M, Dean O, Tandon R, Kasper S, De Hert M Published 9 Dec 2022
9. Distinguishing the Effects of Lead-Time Bias and Duration of Untreated Psychosis: Reply to Jonas et al. [Journal Article] O'Keeffe D, Kinsella A, Waddington J, Clarke M Published 1 Nov 2022
10. From operational diagnostic to dimensional-continuum concepts of psychotic and non-psychotic illness: embracing catatonia across psychopathology and intrinsic movement disorder in neural network dysfunction. [Journal Article] Waddington J Published 13 Oct 2022
11. Dysbindin-1A modulation of astrocytic dopamine and basal ganglia dependent behaviors relevant to schizophrenia. [Journal Article] Mastrogiacomo R, Trigilio G, Devroye C, Dautan D, Ferretti V, Losi G, Caffino L, Orso G, Marotta R, Maltese F, Vitali E, Piras G, Forgiarini A, Pacinelli G, Lia A, Rothmond DA, Waddington J, Drago F, Fumagalli F, Luca MAD, Leggio GM, Carmignoto G, Weickert CS, Managò F, Papaleo F Published 1 Oct 2022
12. Mixed-effects models reveal prediction of long-term outcome by duration of untreated psychosis (DUP) and illness (DUI) varies with quantile gradation but is invariant with time across 7 years in the Cavan-Monaghan First Episode Psychosis Study (CAMFEPS). [Journal Article] Nkire N, Kingston T, Kinsella A, Russell V, Waddington J Published 29 Aug 2022
13. Evaluating the role of common risk variation in the recurrence risk of schizophrenia in multiplex schizophrenia families. [Journal Article] Ahangari M, Gentry AE, Consortium ISG, Nguyen T-H, Kirkpatrick R, Verrelli BC, Bacanu S-A, Kendler KS, Webb BT, Riley BP, Waddington J, Murphy K Published 21 Jul 2022
14. Dysregulation of iron homeostasis and methamphetamine reward behaviors in Clk1-deficient mice. [Journal Article] Yan PJ, Ren ZX, Shi ZF, Wan CL, Han CJ, Zhu LS, Li NN, Waddington J, Zhen XC Published 1 Jul 2022
15. 20-Year Prospective, Sequential Follow-Up Study of Heterogeneity in Associations of Duration of Untreated Psychosis With Symptoms, Functioning, and Quality of Life Following First-Episode Psychosis. [Journal Article] O'Keeffe D, Kinsella A, Waddington J, Clarke M Published 1 Apr 2022
16. The polysemous concepts of psychomotricity and catatonia: A European multi-consensus perspective. [Journal Article] Foucher JR, Jeanjean LC, de Billy CC, Pfuhlmann B, Clauss JME, Obrecht A, Mainberger O, Vernet R, Arcay H, Schorr B, Weibel S, Walther S, van Harten PN, Waddington J, Cuesta MJ, Peralta V, Dupin L, Sambataro F, Morrens M, Kubera KM, Pieters LE, Stegmayer K, Strik W, Wolf CR, Jabs BE, Arms M, Garcia C, Hanke M, Elowe J, Bartsch A, Berna F, Hirjak D Published 1 Mar 2022
17. Allosteric Modulation of the Sigma-1 Receptor Elicits Antipsychotic-like Effects. [Journal Article] Chen J, Li G, Qin P, Ye N, Waddington J, Zhen X Published 1 Mar 2022
18. Dopamine D1 receptors mediate methamphetamine-induced dopaminergic damage: involvement of autophagy regulation via the AMPK/FOXO3A pathway. [Journal Article] He T, Han C, Liu C, Chen J, Yang H, Zheng L, Waddington J, Zhen X Published 1 Mar 2022
19. In vivo microdialysis reveals that blockade of accumbal orexin OX2 but not OX1 receptors enhances dopamine efflux in the nucleus accumbens of freely moving rats. [Journal Article] Kawashima H, Aono Y, Watanabe Y, Waddington J, Saigusa T Published 1 Feb 2022
20. Latent inhibition, aberrant salience, and schizotypy traits in cannabis users. [Journal Article] Dawes C, Quinn D, Bickerdike A, O'Neill C, Granger KT, Pereira SC, Mah SL, Haselgrove M, Waddington J, O'Tuathaigh C, Moran PM Published 5 Jan 2022
21. Cannabis use, schizotypy and Kamin blocking performance. [Journal Article] Dawes C, Bickerdike A, O'Neill C, Pereira SC, Waddington J, Moran PM, O'Tuathaigh CMP Published 23 Nov 2021
22. Schizophrenia vis-à-vis dimensional-spectrum concepts of psychotic illness: Has an answer been ‘hiding in plain sight’? [Journal Article] Waddington J, Nkire N, Russell V Published 17 Nov 2021
23. Transition to clinical practice during the COVID-19 pandemic: a qualitative study of young doctors' experiences in Brazil and Ireland. [Journal Article] Montagna E, Donohoe J, Zaia V, Duggan E, O'Leary P, Waddington J, O’Tuathaigh C Published 22 Sep 2021
24. Sigma-1 receptor regulates mitophagy in dopaminergic neurons and contributes to dopaminergic protection. [Journal Article] Wang M, Wan C, He T, Han C, Zhu K, Waddington J, Zhen X Published 15 Sep 2021
25. White matter microstructure alterations in cortico-striatal networks are associated with parkinsonism in schizophrenia spectrum disorders. [Journal Article] Wasserthal J, Maier-Hein KH, Neher PF, Wolf RC, Northoff G, Waddington J, Kubera KM, Fritze S, Harneit A, Geiger LS, Tost H, Hirjak D Published 1 Sep 2021
26. Carepath for overcoming psychosis early (COPE): first 5-years of clinical operation and prospective research in the Cavan-Monaghan early intervention service. [Journal Article] Fayyaz S, Nkire N, Nwosu B, Amjad N, Kinsella A, Gill M, McDonough C, Russell V, Waddington J Published 6 Aug 2021
27. Integrative opioid-GABAergic neuronal mechanisms regulating dopamine efflux in the nucleus accumbens of freely moving animals. [Journal Article] Saigusa T, Aono Y, Waddington J Published 1 Aug 2021
28. Modeling psychological function in patients with schizophrenia with the PANSS: An international multi-center study. [Journal Article] Fountoulakis KN, Dragioti E, Theofilidis AT, Wiklund T, Atmatzidis X, Nimatoudis I, Thys E, Wampers M, Hranov L, Hristova T, Aptalidis D, Milev R, Iftene F, Spaniel F, Knytl P, Furstova P, From T, Karlsson H, Walta M, Salokangas RKR, Azorin JM, Bouniard J, Montant J, Juckel G, Haussleiter IS, Douzenis A, Michopoulos I, Ferentinos P, Smyrnis N, Mantonakis L, Nemes Z, Gonda X, Vajda D, Juhasz A, Shrivastava A, Waddington J, Pompili M, Comparelli A, Corigliano V, Rancans E, Navickas A, Hilbig J, Bukelskis L, Stevovic LI, Vodopic S, Esan O, Oladele O, Osunbote C, Rybakowski JK, Wojciak P, Domowicz K, Figueira ML, Linhares L, Crawford J, Panfil AL, Smirnova D, Izmailova O, Lecic-Tosevski D, Temmingh H, Howells F, Bobes J, Garcia-Portilla MP, García-Alvarez L, Erzin G, Karadaǧ H, De Sousa A, Bendre A, Hoschl C, Bredicean C, Papava I, Vukovic O, Pejuskovic B, Russell V, Athanasiadis L, Konsta A, Stein D, Berk M, Dean O, Tandon R, Kasper S, De Hert M Published 1 Jun 2021
29. Neuropeptide Y and glutamatergic mechanisms in the amygdala and ventral hippocampus differentially mediate impaired social behavior in diabetic mice. [Journal Article] Ueda D, Yonemochi N, Kamata T, Kamei J, Waddington J, Ikeda H Published 7 May 2021
30. Structural alterations in brainstem, basal ganglia and thalamus associated with parkinsonism in schizophrenia spectrum disorders. [Journal Article] Fritze S, Harneit A, Waddington J, Kubera KM, Schmitgen MM, Otte M-L, Geiger LS, Tost H, Meyer-Lindenberg A, Wolf RC, Hirjak D Published 5 May 2021
31. A neurodevelopmental signature of parkinsonism in schizophrenia. [Journal Article] Wolf RC, Kubera KM, Waddington J, Schmitgen MM, Fritze S, Rashidi M, Thieme CE, Sambataro F, Geiger LS, Tost H, Hirjak D Published 1 May 2021
32. Systematic comparison of duration of untreated illness versus duration of untreated psychosis in relation to psychopathology and dysfunction in the Cavan-Monaghan first episode psychosis study (CAMFEPS). [Journal Article] Nkire N, Scully PJ, Browne DJ, Baldwin PA, Kingston T, Owoeye O, Kinsella A, O'Callaghan E, Russell V, Waddington J Published 3 Apr 2021
33. DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia. [Journal Article] Hannon E, Murphy K, Waddington J, Mill J Published 26 Feb 2021
34. Increase in neuropeptide Y activity impairs social behaviour in association with glutamatergic dysregulation in diabetic mice. [Journal Article] Ueda D, Yonemochi N, Kamata T, Shibasaki M, Kamei J, Waddington J, Ikeda H Published 1 Feb 2021
35. Central dopamine D2 receptors regulate plasma glucose levels in mice through autonomic nerves. [Journal Article] Ikeda H, Yonemochi N, Mikami R, Abe M, Kawamura M, Natsume R, Sakimura K, Waddington J, Kamei J Published 18 Dec 2020
36. Psychotic Disorders. [Chapter] Published by Oxford University Press Published November 2020
37. Early intervention in psychosis: Health economic evaluation using the net benefit approach in a real-world setting. [Journal Article] Behan C, Kennelly B, Roche E, Renwick L, Masterson S, Lyne J, O'Donoghue B, Waddington J, McDonough C, McCrone P, Clarke M Published 1 Sep 2020
38. Movement disorder and sensorimotor abnormalities in schizophrenia and other psychoses - European consensus on assessment and perspectives. [Journal Article] Walther S, van Harten PN, Waddington J, Cuesta MJ, Peralta V, Dupin L, Foucher JR, Sambataro F, Morrens M, Kubera KM, Pieters LE, Stegmayer K, Strik W, Wolf RC, Hirjak D Published 1 Sep 2020
39. Ethologically based behavioural and neurochemical characterisation of mice with isoform-specific loss of dysbindin-1A in the context of schizophrenia. [Journal Article] O'Tuathaigh CMP, Desbonnet L, Payne C, Petit E, Cox R, Loftus S, Clarke G, Cryan JF, Tighe O, Wilson S, Kirby B, Dinan TG, Waddington J Published 29 Jun 2020
40. Early intervention services for psychosis in the metaphorical ‘trenches’ of contemporary care: already known from the real trenches of WW1? [Journal Article] Waddington J Published 28 Jun 2020
41. Refining the resolution of craniofacial dysmorphology in bipolar disorder as an index of brain dysmorphogenesis. [Journal Article] Katina S, Kelly BD, Rojas MA, Sukno FM, McDermott A, Hennessy RJ, Lane A, Whelan PF, Bowman AW, Waddington J Published 18 Jun 2020
42. Does cannabis use predict psychometric schizotypy via aberrant salience? [Journal Article] O'Tuathaigh CMP, Dawes C, Bickerdike A, Duggan E, O'Neill C, Waddington J, Moran PM Published 6 Apr 2020
43. Development and characterization of an inducible Dicer conditional knockout mouse model of Parkinson’s disease: validation of the antiparkinsonian effects of a sigma-1 receptor agonist and dihydromyricetin. [Journal Article] Guo CH, Cao T, Zheng LT, Waddington J, Zhen XC Published 1 Apr 2020
44. Psychosis in Parkinson’s disease and parkinsonism in antipsychotic-naive schizophrenia spectrum psychosis: clinical, nosological and pathobiological challenges. [Journal Article] Waddington J Published 5 Mar 2020
45. Developmental genes and regulatory proteins, domains of cognitive impairment in schizophrenia spectrum psychosis and implications for antipsychotic drug discovery: the example of dysbindin-1 isoforms and beyond. [Journal Article] Waddington J, Zhen X, O'Tuathaigh CMP Published 29 Jan 2020
46. Systematic epidemiological and clinical comparisons across all 12 DSM-IV psychotic diagnoses in the Cavan-Monaghan First Episode Psychosis Study (CAMFEPS). [Journal Article] Nkire N, Scully PJ, Browne DJ, Baldwin PA, Kingston T, Owoeye O, Kinsella A, O'Callaghan E, Russell V, Waddington J Published 20 Dec 2019
47. Forging successful partnerships in psychosis research: Lessons from the Cavan-Monaghan First Episode Psychosis Study. [Journal Article] Russell V, Nkire N, Kingston T, Waddington J Published 1 Dec 2019
48. Acute stress in adolescence vs early adulthood following selective deletion of dysbindin-1A: Effects on anxiety, cognition and other schizophrenia-related phenotypes. [Journal Article] Desbonnet L, O’Tuathaigh CMP, O’Leary C, Cox R, Tighe O, Petit EI, Wilson S, Waddington J Published 1 Dec 2019
49. Dopaminergic mechanisms in the lateral hypothalamus regulate feeding behavior in association with neuropeptides. [Journal Article] Yonemochi N, Ardianto C, Yang L, Yamamoto S, Ueda D, Kamei J, Waddington J, Ikeda H Published 12 Nov 2019
50. D2 receptor-mediated miRNA-143 expression is associated with the effects of antipsychotic drugs on phencyclidine-induced schizophrenia-related locomotor hyperactivity and with Neuregulin-1 expression in mice. [Journal Article] Wang P, Cao T, Chen J, Jiang Y, Wang C, Waddington J, Zhen X Published 1 Oct 2019
51. Staging of schizophrenia with the use of PANSS: an international multi-center study. [Journal Article] Fountoulakis KN, Waddington J, Pejuskovic B, Russell V, de Hert M Published 30 Sep 2019
52. A polygenic resilience score moderates the genetic risk for schizophrenia. [Journal Article] Hess JL, Murphy K, Waddington J, Glatt SJ Published 6 Sep 2019
53. The Cavan-Monaghan First Episode Psychosis Study (CAMFEPS): arbitrary diagnostic boundaries across the gene-environment interface and within evolving models of care. [Journal Article] Waddington J, Russell V Published 12 Apr 2019
54. In vivo neurochemical evidence that stimulation of accumbal GABA A and GABA B receptors each reduce acetylcholine efflux without affecting dopamine efflux in the nucleus accumbens of freely moving rats. [Journal Article] Aono Y, Watanabe Y, Ishikawa M, Kuboyama N, Waddington JL, Saigusa T Synapse 73(4) Published 1 Apr 2019