电话:01-4022582
地址:1st Floor Ardilaun House, Block B, 111 St. Stephen's Green, Dublin 2., Ireland
个人简介:
Tracy Robson教授于1996年获得伦敦帝国理工学院分子辐射科学博士学位。她的第一个学术职位是1997年在阿尔斯特大学担任辐射科学讲师。2004年她转到贝尔法斯特女王大学药学院,担任分子药理学讲师,2010年晋升为实验治疗学教授。她于2016年8月加入RCSI,担任分子与细胞治疗学(MCT)教授和负责人。她承担了一流药物的开发,获得五项专利和超过750万欧元的研究资金,发表了80余篇刊物。
研究方向:
Tracy Robson教授的研究重点是开发使肿瘤对个性化医学治疗敏感的新方法,旨在识别和功能表征改变肿瘤对抗癌药物反应的基因。她与她的团队克隆并鉴定了一种新的人类基因FKBPL,并证明了FKBPL作为一种自然分泌的抗血管生成蛋白的细胞外作用。她领导了基于FKBPL活性抗血管生成结构域的治疗性肽衍生物(AD-01和ALM201)的开发。基于稳健的疗效和优异的安全性,ALM201已完成配方和毒理学测试,并已进入I/II期癌症临床试验(edract号:2014-001175-31)。通过转基因小鼠模型的发展,她还证明了FKBPL在预防一系列与血管调节和炎症相关的其他疾病中的作用。
查看更多关于Robson研究小组的信息:https://robsonlab.com/our-lab/
近期论文:
1.The concise guide to pharmacology 2023/24: enzymes.[Journal Article]Alexander SPH, Annett S, Robson T, Wong SSPublished 20 Dec 2023
2.Glycolytic reprogramming fuels myeloid cell-driven hypercoagulability.[Journal Article]Rehill A, Leon G, McCluskey S, Schoen I, Hernandez-Santana Y, Annett S, Klavina P, Robson T, Curtis A, Renné T, Hussey S, O'Donnell J, Walsh P, Preston RPublished 19 Oct 2023
3.Obesity, non-alcoholic fatty liver disease and hepatocellular carcinoma: current status and therapeutic targets.[Journal Article]Chen Y, Wang W, Morgan M, Robson T, Annett SPublished 8 Jun 2023
4.FK506-binding protein like (FKBPL) has an important role in heart failure with preserved ejection fraction pathogenesis with potential diagnostic utility.[Journal Article]Chhor M, Chen H, Jerotić D, Tešić M, Nikolić VN, Pavlović M, Vučić RM, Rayner B, Watson CJ, Ledwidge M, McDonald K, Robson T, McGrath KC, McClements LPublished 18 Feb 2023
5. Proceedings of the 6th International Workshop on Semantic Web Solutions for Large-scale Biomedical Data Analytics - SeWebMeDa-2023. [Conference] Hasnain A, Robson T, Dumontier M, Tirado AM, Rebholz-Schuhmann D Published 1 Jan 2023
6.Precision medicine and novel therapeutic strategies in detection and treatment of cancer: highlights from the 58th IACR annual conference.[Journal Article]Kennedy SP, Treacy O, Allott EH, Eustace AJ, Lynam-Lennon N, Buckley N, Robson TPublished 16 Dec 2022
7.Enhancing arginase 2 expression using target site blockers as a strategy to modulate macrophage phenotype.[Journal Article]De Santi C, Nally F, Afzal R, Duffy CP, Fitzsimons S, Annett S, Robson T, Dowling J, Cryan S-A, McCoy CPublished 4 Aug 2022
8.Dexamethasone promotes breast cancer stem cells in obese and not lean mice.[Journal Article]Annett S, Fox OW, Vareslija D, Robson TPublished 14 Mar 2022
9. Proceedings of the 5th International Workshop on Semantic Web Solutions for Large-scale Biomedical Data Analytics - SeWebMeDa-2022. [Conference] Hasnain A, Robson T, Dumontier M Published 1 Jan 2022
10.Characterizing and exploiting tumor microenvironments to optimize treatment outcomes.[Journal Article]Allott EH, Dean K, Robson T, Meaney CPublished 17 Nov 2021
11.The concise guide to pharmacology 2021/22: enzymes.[Journal Article]Alexander SPH, Annett S, Robson T, Wong SSPublished 16 Sep 2021
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12.Effect of the rehabilitation program, ReStOre, on serum biomarkers in a randomized control trial of esophagogastric cancer survivors.[Journal Article]Kennedy SA, Annett S, Dunne MR, Boland F, O’Neill LM, Guinan EM, Doyle SL, Foley EK, Elliott JA, Murphy CF, Bennett AE, Carey M, Hillary D, Robson T, Reynolds JV, Hussey J, O’Sullivan JPublished 15 Sep 2021
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13.Non-viral gene delivery utilizing RALA modulates sFlt-1 secretion, important for preeclampsia.[Journal Article] McNally R, Alqudah A, McErlean EM, Rennie C, Morshed N, Short A, McGrath K, Shimoni O, Robson T, McCarthy HO, McClements L Published 1 Sep 2021
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14.Educating pharmacy students through a pandemic: reflecting on our COVID-19 experience.[Journal Article] Strawbridge J, Hayden J, Robson T, Flood M, Cullinan S, Lynch M, Morgan A-T, O'Brien F, Reynolds R, Kerrigan S, Cavalleri G, Kirby B, Tighe O, Maher A, Barlow J Published 17 Aug 2021
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15Dexamethasone promotes breast cancer stem cells in obese and not lean mice.[Journal Article] Annett S, Fox OW, Vareslija D, Robson T Published 18 Jun 2021
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16.FKBPL and SIRT-1 are downregulated by diabetes in pregnancy impacting on angiogenesis and endothelial function.[Journal Article] Alqudah A, Eastwood K-A, Jerotic D, Todd N, Hoch D, McNally R, Obradovic D, Dugalic S, Hunter AJ, Holmes VA, McCance DR, Young IS, Watson CJ, Robson T, Desoye G, Grieve DJ, McClements L Published 2 Jun 2021
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17.The cancer stem cell niche in ovarian cancer and its impact on immune surveillance.[Journal Article] Jain S, Annett S, Morgan M, Robson T Published 15 Apr 2021
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18.Prognostic significance of glucocorticoid receptor expression in cancer: A systematic review and meta-analysis.[Journal Article] Bakour N, Moriarty F, Moore G, Robson T, Annett S Published 1 Apr 2021
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19.Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages.[Journal Article] Dowling J, Afzal R, Gearing LJ, Silva MPC, Annett S, Davis GM, De Santi C, Assmann N, Dettmer K, Gough DJ, Bantug GR, Hamid FI, Nally F, Duffy C, Gorman AL, Liddicoat AM, Lavelle EC, Hess C, Oefner PJ, Finlay DK, Davey GP, Robson T, Curtis A, Hertzog PJ, Williams BRG, McCoy C Published 5 Mar 2021
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20.Rational design and characterisation of an amphipathic cell penetrating peptide for non-viral gene delivery.[Journal Article] McErlean EM, McCrudden CM, McBride JW, Cole G, Kett VL, Robson T, Dunne NJ, McCarthy HO Published 27 Jan 2021
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21.Peptidyl-prolyl cis/trans isomerases (version 2021.2) in the IUPHAR/BPS Guide to Pharmacology Database.[Journal Article] Annett S, Robson T Published 1 Jan 2021
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22.Obesity and cancer metastasis: Molecular and translational perspectives.[Journal Article] Annett S, Moore G, Robson T Published 16 Dec 2020
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23.FKBPL is associated with metabolic parameters and is a novel determinant of cardiovascular disease.[Journal Article] Januszewski AS, Watson CJ, O’Neill V, McDonald K, Ledwidge M, Robson T, Jenkins AJ, Keech AC, McClements L Published 10 Dec 2020
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24.Rational design and characterisation of a linear cell penetrating peptide for non-viral gene delivery.[Journal Article] McErlean EM, Ziminska M, McCrudden CM, McBride JW, Loughran SP, Cole G, Mulholland EJ, Kett V, Buckley NE, Robson T, Dunne NJ, McCarthy HO Published 1 Nov 2020
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25.Role of a novel angiogenesis FKBPL-CD44 pathway in preeclampsia risk stratification and mesenchymal stem cell treatment.[Journal Article] Todd N, McNally R, Alqudah A, Jerotic D, Suvakov S, Obradovic D, Hoch D, Hombrebueno JR, Campos GL, Watson CJ, Gojnic-Dugalic M, Simic TP, Krasnodembskaya A, Desoye G, Eastwood K-A, Hunter AJ, Holmes VA, McCance DR, Young IS, Grieve DJ, Kenny LC, Garovic VD, Robson T, McClements L Published 3 Jul 2020
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26.FK506 binding proteins and inflammation related signalling pathways; basic biology, current status and future prospects for pharmacological intervention.[Journal Article] Annett S, Moore G, Robson T Published 2 Jul 2020
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27.Top notch targeting strategies in cancer: a detailed overview of recent insights and current perspectives.[Journal Article] Moore G, Annett S, McClements L, Robson T Published 20 Jun 2020
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28.FKBPL, a novel player in cardiac ischaemia and fibrosis.[Journal Article] McClements L, Rayner B, Alqudah A, Grieve D, Robson T Published 1 Mar 2020
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29.FKBPL-based peptide, ALM201, targets angiogenesis and cancer stem cells in ovarian cancer.[Journal Article] Annett S, Moore G, Short A, Marshall A, McCrudden C, Yakkundi A, Das S, McCluggage WG, Nelson L, Harley I, Moustafa N, Kennedy CJ, deFazio A, Brand A, Sharma R, Brennan D, O’Toole S, O’Leary J, Bates M, O’Riain C, O'Connor D, Furlong F, McCarthy H, Kissenpfennig A, McClements L, Robson T Published 27 Nov 2019
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30.Delivery of RALA/siFKBPL nanoparticles via electrospun bilayer nanofibres: an innovative angiogenic therapy for wound repair.[Journal Article] Mulholland EJ, Ali A, Robson T, Dunne NJ, McCarthy HO Published 30 Oct 2019
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31.DNA vaccination via RALA nanoparticles in a microneedle delivery system induces a potent immune response against the endogenous prostate cancer stem cell antigen.[Journal Article] Cole G, Ali AA, McErlean E, Mulholland EJ, Short A, McCrudden CM, McCaffrey J, Robson T, Kett VL, Coulter JA, Dunne JA, Donnelly RF, McCarthy HO Published 9 Jul 2019
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32.FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4.[Journal Article] McClements L, Annett S, Yakkundi A, O'Rourke M, Valentine A, Moustafa N, Alqudah A, Simões BM, Furlong F, Short A, McIntosh SA, McCarthy HO, Clarke RB, Robson T Published 11 Apr 2019