Prof Qimin Zhan
Dean of Suzhou Medical College
Molecular oncologist
Academician of the Chinese Academy of Engineering
Biography
Prof Qimin Zhan is a world-renowned molecular oncologist and an academician of the Chinese Academy of Engineering. He used to work for Peking University as Deputy President and currently serves as Dean of Suzhou Medical College at Soochow University. He has been long committed to the research of molecular biology of tumors and translational medicine of tumors. In recent years, he has comprehensively and systematically revealed the genetic mutation background of esophageal cancer at the genomic level, providing a theoretical and experimental basis for understanding the pathogenesis of esophageal cancer, finding molecular markers for the diagnosis of esophageal squamous cell carcinoma, and determining drug targets for clinical treatment.
His research is at the international forefront of the field and is highly recognized by peers domestically and internationally. He has published over 270 SCI papers, including in journals such as Nature, Cell, Cell Research, Nature Communication, JCI, PNAS, Science, EMBO, Cancer Res, and Oncogene. His scientific papers have been cited over 16,200 times in SCI. He has edited or translated 7 academic works, applied for 14 invention patents, and obtained 8 authorized patents. He has been invited to deliver over 120 keynote speeches at domestic and international academic conferences and served as chairman of international conferences or bilateral meetings 15 times. He has been invited to serve as an editorial board member for international biomedical and oncology journals such as Cancer Cell, JBC, Molecular Oncology, and Carcinogenesis. He is the editor-in-chief of Data Health and Medical Review and the deputy editor-in-chief of Science Bulletin and Chinese Journal of Oncology. He has also been invited to write reviews for important international oncology journals such as British J Cancer and Mutation Res.
Research Interests
Molecular oncology; Translational cancer medicine research
Representative Publications
1. Song Y, Li L, Ou Y, Gao Z, Li E, Li X, Zhang W, Wang J, Xu L, Zhou Y, Ma X, Liu L, Zhao Z, Huang X, Fan J, Dong L, Chen G, Ma L, Yang J, Chen L, He M, Li M, Zhuang X, Huang K, Qiu K, Yin G, Guo G, Feng Q, Chen P, Wu Z, Wu J, Ma L, Zhao J, Luo L, Fu M, Xu B, Chen B, Li Y, Tong T, Wang M, Liu Z, Lin D, Zhang X, Yang H, Wang J, Zhan Q. Identification of genomic alterations in oesophageal squamous cell cancer. Nature. 2014, 509(7498):91-95.
2. Shujuan Shao, Rong Liu, Yang Wang, Yongmei Song, Lihui Zuo, Liyan Xue, Ning Lu, Ning Hou, Mingrong Wang, Xiao Yang, Qimin Zhan.Centrosomal Nlp is an oncogenic protein that is gene-amplified in human tumors and causes spontaneous tumorigenesis in transgenic mice, Journal of Clinical Investigation. 2010, 36(120): 498-507.
3. Li, X., L. Shi, Y. Wang, J. Zhong, X. Zhao, H. Teng, X. Shi, H. Yang, S. Ruan, M. Li, Z. S. Sun*, Q. Zhan* and F. Mao*. OncoBase: a platform for decoding regulatory somatic mutations in human cancers, 2019, Nucleic Acids Research.2019, 47(D 1): D1044-D1055.
4. Yan T, Cui H, Zhou Y, Yang B, Kong P, Zhang Y, Liu Y, Wang B, Cheng Y, Li J, Guo S, Xu E, Liu H, Cheng C, Zhang L, Chen L, Zhuang X, Qian Y, Yang J, Ma Y, Li H, Wang F, Liu J, Liu X, Su D, Wang Y, Sun R, Guo S, Li Y, Cheng X, Liu Z, Zhan Q*, Cui Y*. Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma. Nature Communications. 2019, 10(1): 1670.
5. Dongdong Zhang, Weimin Zhang, Dan Li, Ming Fu, Runsheng Chen, Qimin Zhan. GADD45A inhibits autophagy by regulating the interaction between BECN1 and PIK3C3. Autophagy.2015, 11(12): 2247-2258.
6. Dan Li, Xuefeng Liu, Jian Zhou, Jie Hu, Dongdong Zhang, Jing Liu, Yanyan Qiao, Qimin Zhan. Long noncoding RNA HULC modulates the phosphorylation of YB-1 through serving as a scaffold of extracellular signal-regulated kinase and YB-1 to enhance hepatocarcinogenesis. Hepatology. 2017, 65(5):1612-1627.
7. Xuefeng Liu, Dan Li, Weimin Zhang, Mingzhou Guo, Qimin Zhan. Long non-coding RNA gadd7 interacts with TDP-43 and regulates Cdk6 mRNA decay. EMBO Journal. 2012, 31(23): 4415–4427.
8. Cui Y, Chen H, Xi R, Cui H, Zhao Y, Xu E, Yan T, Lu X, Huang F, Kong P, Li Y, Zhu X, Wang J, Zhu W, Wang J, Ma Y, Zhou Y, Guo S, Zhang L, Liu Y, Wang B, Xi Y, Sun R, Yu X, Zhai Y, Wang F, Yang J, Yang B, Cheng C, Liu J, Song B, Li H, Wang Y, Zhang Y, Cheng X, Zhan Q*, Li Y*, Liu Z*. Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma. Cell Research.2020, 30(10): 902-913
9. Jie Chen, Yan Wang, Weimin Zhang, Di Zhao, Lingyuan Zhang, Jiawen Fan, Jinting Li, Qimin Zhan. Membranous NOX5-derived ROS oxidizes and activates local Src to promote malignancy of tumor cells. Signal Transduction and Targeted Therapy. 2020, 5(139): 1-12.
10. Gao, X., Y. Wang, F. Lu, X. Chen, D. Yang, Y. Cao, W. Zhang, J. Chen, L. Zheng, G. Wang, M. Fu, L. Ma, Y. Song and Q. Zhan. Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway, Journal of Extracellular Vesicles. 2021, 10(5): e12060.
