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Xinchen Teng
Associate Professor
Vice Dean of the International College of Pharmaceutical Innovation
E-mail: xcteng@suda.edu.cn
Biography
Dr. Xinchen Teng obtained her Bachelor's and Master's degrees in Chemistry from Fudan University in 2001 and 2004. From 2004 to 2010, she pursued her PhD in Biochemistry, Cellular, and Molecular Biology at Johns Hopkins University School of Medicine in the United States. She then continued her postdoctoral work at the Bloomberg School of Public Health at Johns Hopkins University. She became an associate professor at the College of Pharmaceutical Sciences, Soochow University in 2013. Her research primarily focuses on cell growth signalling pathways and programmed cell death mechanisms related to cancer. She has published in high-profile journals such as Mol Cell, PLoS Genet., Cell Reports, Cell Death Dis., and Ann Neurol. She has led two projects funded by the National Natural Science Foundation and one project funded by the Jiangsu Provincial Natural Science Foundation.
Research Interest
Regulation mechanisms of TORC1 activity in response to specific amino acid signals
High-throughput screening and identification of programmed cell death genes
Regulation mechanisms of GSDM protein-induced pyroptosis
Select Publications
1. Wang Y, Engel T,Teng X* (2024) Post-translational regulation of the mTORC1 pathway: A switch that regulates metabolism-related gene expression,Biochim Biophys Acta Gene Regul Mech.1867:195005
2. Stolp ZD, Kulkarni M, Liu Y, Zhu C, Jalisi A, Lin S, Casadevall A, Cunningham KW, Pineda FJ,Teng X, Hardwick JM* (2022) Yeast cell death pathway requiring AP-3 vesicle trafficking leads to vacuole/lysosome membrane permeabilization,Cell Rep.39:110647
3.Teng X, Aouacheria A, Lionnard L, Metz KA, Soane L, Kamiya A, Hardwick JM* (2019) KCTD: A new gene family involved in neurodevelopmental and neuropsychiatric disorders,CNS Neurosci Ther.25, 887-902.
4. Yang X, Wang G, Cao T, Zhang L, Ma Y, Jiang S,Teng X, Sun X* (2019) Large-conductance calcium-activated potassium channels mediate lipopolysaccharide-induced activation of murine microglia,J Biol Chem.294, 12921-12932.
5. Metz KA,Teng X, Coppens I, Lamb HM, Wagner BE, Rosenfeld JA, Chen X, Zhang Y, Kim HJ, Meadow ME, Wang TS, Haberlandt ED, Anderson GW, Leshinsky-Silver E, Bi W, Markello TC, Pratt M, Makhseed N, Garnica A, Danylchuk NR, Burrow TA, Jayakar P, McKnight D, Agadi S, Gbedawo H, Stanley C, Alber M, Prehl I, Peariso K, Ong MT, Mordekar SR, Parker MJ, Crooks D, Agrawal PB, Berry GT, Loddenkemper T, Yang Y, Maegawa GHB, Aouacheria A, Markle JG, Wohlschlegel JA, Hartman AL, Hardwick JM* (2018) KCTD7 deficiency defines a distinct neurodegenerative disorder with a conserved autophagy-lysosome defect,Ann Neurol.84, 766-780
6. Chen X, Wang G, Zhang Y, Dayhoff-Brannigan M, Diny NL, Zhao M, He G, Sing CN, Metz KA, Stolp ZD, Aouacheria A, Cheng WC, Hardwick JM*,Teng X*(2018) Whi2 is a conserved negative regulator of TORC1 in response to low amino acids,PLoS Genetics.14, e1007592
7.Teng X*and Hardwick JM* (2018) Whi2: a new player in amino acid sensing,Curr Genet.65, 701-709.
8.Teng X, Yau E, Sing C, Hardwick JM (2018) Whi2 signals low amino acid availability to halt yeast growth and cell death,FEMS Yeast Res.18, foy095
9.Teng X*and Hardwick JM* (2015) Cell death in genome evolution,Semin Cell Dev Biol.39, 3-11
10.Teng X*and Hardwick JM* (2014) Genome evolution in yeast reveals connections between rare mutations in human cancers,Microb Cell.1, 206-209
11.Teng X, Dayhoff-Brannigan M, Cheng W-C, Gilbert CE, Wheelan SJ, Dunham MJ, Boeke JD, Pineda FJ and Hardwick JM (2013)Genome-wide consequences of deleting any single gene,Mol Cell. 52,485-494.
12.Teng X, Cheng W-C, Qi B, Yu T-X, Ramachandran K, Boersma MD, Hattier T, Lehmann PV, Pineda FJ and Hardwick JM (2011) Gene-dependent cell death in yeast,Cell Death Dis.2, e188
