Guangming Zhou,PhD
Professor, School of Radiation Medicine and Protection,Soochow University,
Suzhou215123,China
Tel: 86-512-65880052, Fax: 86-512-65884830
E-mail:gmzhou@suda.edu.cn
Education Background:
PhD inParticle Physics and Nuclear Physics,University ofChinese Academy of Sciences, China,2001
BSc inBiochemistry,LanzhouUniversity, China,1994
ProfessionalExperience:
2015---:Professorin Radiobiology,School of Radiation Medicine and Protection, Soochow University, China
2007---2015:Professorin Biophysics,director of theDepartment ofSpace Radiobiology, Institute of Modern Physics, Chinese Academy of Sciences, China
2007---2005: Post-doc,Center for Radiation Research, ColumbiaUniversity, USA
2003---2005: Post-doc,BiologyDepartment, Brookhaven National Laboratory, USA
2002---2003: Visiting Scholar,School of Radiation Medicine, Chiba University, Japan
2001---2003: Assistant Professor, Institute of Modern Physics, Chinese Academy of Sciences, China
Research Interests:
Biological effects of heavy ion beam
Biogenesis of cancer stem cells induced by ionizing radiation
Functions of radiation-inducible non-coding RNAs
Development of anti-radiation drugs
Research Experience andAccomplishments:
1. Elucidated a novel mechanism of cellular radiosensitivity, namely cell cycle suspension and consequent G2 slippage.
2. Identified 10 kinds of novel microRNAs and experimentally revealed a microRNA-protein network regulating radiobiological effects induced by ionizing radiation.
3. Studied the radiobiological effects of various kinds of heavy particles and secondary radiation.
4. Developed a free radical scavenger.
Recent Publications (*Corresponding author):
1.Hu W, Xu S, Yao B, Hong M, Wu X, Pei H, Chang L, Ding N, Gao X, Ye, C, Wang J, Hei TK andZhou G*. 2014, miR-663 inhibits radiation-induced bystander effects by targetingTGFB1in a feedback mode.RNA Biology, 11(9): 1189-1198.
2. Liu T, Pei H, Xu D, Zhang Y, Wan J, Wu X, Zhang X, Sun F, He J, Li P, Tian L, Wang J, Chen W,Zhou G*. 2014, GANRA-5 protects mice from X-ray irradiation-induced dysfunction of immune system.Free Radical Research, 48(8): 875-882
3. Pei H, Chen W, Hu W, Zhu M, Liu T, Wang J andZhou G*. 2014, GANRA-5 protects both cultured cells and mice from various radiation types by functioning as a free radical scavenger.Free Radical Research, 48(6): 670-678.
4. Zhang H, Sun Z, Wei W, Liu Z, Fleming J, Zhang J, Lin N, Wang M, Chen M, Xu Y, Zhou J, Li C, Bi L,Zhou G*. 2014, Identification of serum microRNA biomarkers for tuberculosis using RNA-seq.PLoS ONE, 9(2): e88909.
5. Hu W, Pei H, Ding N, He J, Wang J, Furusawa Y, Hirayama R, Matsumoto Y, Liu C, Kawata T,Zhou G*. 2014, Effects of shielding on the induction of 53BP1 foci and micronuclei after Fe ion exposures.Journal of Radiation Research, 55(1): 10-16.
6. Wang J, He J, Su F, Ding D, Hu W, Yao B, Wang W, andZhou G*. 2013, Repression of ATR pathway by miR-185 enhances radiation-induced apoptosis and proliferation inhibition.Cell Death and Disease, 4: e699.
7. Ye C, Zhang X, Wan J, Chang L, Bing Z, Zhang S, Li J, He J, Wang J*,Zhou G*. 2013, Long-term G2-arrested cells exposed to ionizing radiation undergo cellular senescence via slipping into the G1 phase.Cell Cycle, 12(9): 1424-1432.
8. Ding N, Pei H, He J, Furusawa Y, Hirayama R, Liu C, Matsumoto Y, Li H, Hu W, Li Y, Wang J, Wang T,Zhou G*. 2013, Simulated studies on the biological effects of space radiation on quiescent human fibroblasts.Advances in Space Research, 52: 1314-1319.
9. Wang F, Bing Z, Zhang Y, Ao B, Zhang S, Ye C, He J, Ding N, Ye W, Xiong J, Sun J, Furusawa Y,Zhou G*, and Yang L. 2013, Quantitative proteomic analysis for radiation-induced cell cycle suspension in 92-1 melanoma cell line.Journal of Radiation Research, 54(4): 649-62.
10. Chang L,HuW,YeC,YaoB,SongL,WuX, Ding N, Wang J, andZhou G*. 2012, miR-3928 activates ATR pathway by targeting dicer.RNA Biology, 9(10): 1247-1254.
11. He J, Li J, Ye C, Zhou L, Zhu J, Wang J, Mizota A, Furusawa Y, andZhou G*. 2011, Cell cycle suspension: A novel process lurking in G2 arrest.Cell Cycle, 10(9): 1468-1476.
12. Wang J, Su F, Smilenov LB, Zhou L, Hu W, Ding N, andZhou G*. 2011, Mechanisms ofincreased risk of tumorigenesis in Atm and Brca1 double heterozygosity.Radiation Oncology, 6: 96.
13. Ding N, Wu X, He J, Chang L, Hu W, Li W, Wang J, Wang T, andZhou G*. 2011, Detection of novel human miRNAs responding to X-ray irradiation.Journal of Radiation Research, 52: 425-432.
14.Zhou G, Smilenov LB, Lieberman HB, Ludwig T, Hall EJ. Radiosensitivity to high energy iron ions is influenced by heterozygosity for ATM, RAD9 and BRCA1. 2010,Advances in Space Research, 46: 681-686
Honors and Awards:
2010,Collaboration and Multidisplinary Teamof the Chinese Academy of Sciences
2008, Hundred Talent Program of the Chinese Academy of Sciences
Contact Information：
Address: 199 Renai Road, Suzhou 215123, China
Cell: 86-13914058572
Email:gmzhou@suda.edu.cn