Title： |
Exploration of Ultrasound-Sensitive Biomaterials in Cancer Theranostics |
Authors： |
Yuqi Yang1,2,5, Huazheng Liang2,3, Chun Tang4, Yuan Cheng2,5, Liang Cheng1,6 |
Institutions： |
1Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou 215123 China 2Monash Suzhou Research Institute, Monash University, Suzhou 215000, China 3Australian Regenerative Medicine Institute, Clayton, VIC 3800, Australia 4Faculty of Civil Engineering and Mechanics, Jiangsu University, Zhenjiang 212013, China 5Department of Materials Science and Engineering, Monash University, Clayton, VIC 3800, Australia 6Macao Institute of Materials Science and Engineering, Macau University of Science and Technology, Taipa, Macau SAR 999078, China |
Abstract： |
Cancer is a serious health problem to be solved. With the development of biomaterials, enhanced diagnostic and controllable therapeutic strategies for cancer have emerged, revealing encouraging results with a promising future. Due to its outstanding tissue penetration and controllability, along with a series of bioeffects on tissues, ultrasound (US), as a common medical technology, has been regarded as an effective tool against cancer, and its use has promoted the exploration of US-sensitive biomaterials. In this review, the bioeffects of US are first introduced and then the main US-sensitive biomaterials (containing cavitation nuclei, sonosensitizers, and US-responsive macromolecular systems) used to treat cancer, followed by a summary of several applications based on US-sensitive biomaterials, from diagnosis to therapy. Finally, the emerging challenges in this field that need to be overcome are highlighted. This review reports the progress of US-sensitive biomaterials, providing new possibilities in cancer theranostics and thus benefiting patients. |
IF： |
19.924 |
Link： |
Editor: Guo Jia