Rare Earth Amide-Catalyzed Direct Thioesterification of Aldehydeswith Thiols under Mild Conditions
Nadia Ismaeel1, Sajid Imran1, Xuehua Zhu2, Jue Chen,3*（陈珏）Dan Yuan1*（袁丹）, and Yingming Yao1*（姚英明）
1Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Dushu Lake Campus, Soochow University, Suzhou 215123, People’s Republic of China
2School of Chemistry and Life Science, SuzhouUniversity of Science and Technology, Suzhou 215009,People’s Republic of China
3School of Biological and Chemical Engineering,NingboTech University, Ningbo 315100, People’s Republic ofChina
Org. Lett.2023, 25, 8672−8676
Abstract: Direct thioesterification of aldehydes with thiolscatalyzed by readily accessible rare earth/lithium amide RE[N-(SiMe3)2]3(μ-Cl)Li(THF)3is developed, which enables thepreparation of a range of thioesters (31 examples) under room temperatureand solvent-free conditions, without using any additive or externaloxidant. This method provides a straightforward and atom-efficientapproach for the thioester synthesis.
链接：https://pubs.acs.org/doi/10.1021/acs.orglett.3c03497
